Article
Biochemistry & Molecular Biology
Giovanna Trinchese, Fabiano Cimmino, Gina Cavaliere, Luigi Rosati, Angela Catapano, Daniela Sorriento, Elisabetta Murru, Luca Bernardo, Luciana Pagani, Paolo Bergamo, Rosaria Scudiero, Guido Iaccarino, Luigi Greco, Sebastiano Banni, Marianna Crispino, Maria Pina Mollica
Summary: This study investigated the impact of different types of dairy consumption on heart mitochondrial functions, inflammation, and oxidative stress, finding that dietary supplementation with various types of milk can significantly affect metabolic and inflammatory status through modulation of mitochondrial functions.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano, Sabrina Castellano
Summary: The increase in life expectancy has led to a higher prevalence of age-related neurological diseases, such as cognitive impairment, dementia, and Alzheimer's disease. This study aimed to examine the association between specific categories and subcategories of dietary fats and cognitive status in older Italian adults. The results showed that moderate consumption of certain types of saturated fatty acids and monounsaturated fatty acids was associated with a lower risk of cognitive impairment, while moderate intake of linoleic acid was associated with a higher risk of cognitive impairment.
Article
Biochemistry & Molecular Biology
Simona Mattioli, Corrado Dimauro, Alberto Cesarani, Alessandro Dal Bosco, Desiree Bartolini, Francesco Galli, Anna Migni, Bartolomeo Sebastiani, Cinzia Signorini, Camille Oger, Giulia Collodel, Cesare Castellini
Summary: The study aimed to develop a dynamic model using rabbits as a model to evaluate the balance between reactive oxygen species, polyunsaturated fatty acids, and antioxidants. The model showed good accuracy in predicting the effects of dietary treatments on the redox homeostasis of rabbits.
Article
Food Science & Technology
Maria A. Lankinen, Vanessa D. de Mello, Topi Meuronen, Taisa Sallinen, Jyrki Agren, Kirsi A. Virtanen, Markku Laakso, Jussi Pihlajamaki, Ursula Schwab
Summary: The study demonstrates that the FADS1 genotype modifies the response to high PUFA diets, especially to high-LA diet. Considering FADS variation in personalized dietary counseling may be beneficial for individuals.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Nutrition & Dietetics
Alice Cartoni Mancinelli, Simona Mattioli, Cornelia Twining, Alessandro Dal Bosco, Ann M. Donoghue, Komala Arsi, Elisa Angelucci, Diletta Chiattelli, Cesare Castellini
Summary: This study provides an overview of the main strategies for enriching and preserving n-3 LC-PUFA in poultry products, which include dietary supplementation and improving rearing conditions. Additionally, factors such as genotype, rearing system, transport, and cooking processes can impact the content of this fatty acid in poultry products.
Article
Chemistry, Medicinal
Sai Zhang, Xiaohong Chen, Biswarup Sen, Mohan Bai, Yaodong He, Guangyi Wang
Summary: Species of Schizochytrium are well known for their ability to produce lipids intracellularly. In this study, seven different natural antioxidants were evaluated for their effects on lipid accumulation in Schizochytrium sp. PKU#Mn4. Mannitol showed the best increment in total fatty acids concentration, with interactions between mannitol and ascorbic acid resulting in increased saturated and polyunsaturated fatty acids concentrations. This study provides insights into strategies for improving lipid accumulation in thraustochytrids using exogenous antioxidants and the underlying mechanisms.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Grosso, Raffaele Ivan Cincione, Sandro La Vignera, Silvio Buscemi, Fabio Galvano
Summary: This study examined the association between specific types and subtypes of dietary fats and metabolic outcomes in Italian adults. The results suggest that higher intake of total and saturated fats may be associated with a lower likelihood of hypertension. Additionally, the intake of short-chain and medium-chain saturated fatty acids, as well as certain monounsaturated fatty acids, may be inversely associated with dyslipidemia and diabetes.
Review
Food Science & Technology
Martina Cretton, Gabriela Malanga, Tania Mazzuca Sobczuk, Marcia Mazzuca
Summary: This review focuses on the importance of lipids from marine organisms in human nutrition, as well as the methods and resources used for the production and extraction of these nutritional lipid molecules. The emphasis is on the use of residual biomass from fisheries to improve the sustainability of the fish industry.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Adriana Flores-Lopez, Martha Guevara-Cruz, Azalia Avila-Nava, Alejandro G. Gonzalez-Garay, Luis E. Gonzalez-Salazar, Ana L. Reyes-Ramirez, Jose Pedraza-Chaverri, Omar N. Medina-Campos, Isabel Medina-Vera, Juan G. Reyes-Garcia, Armando R. Tovar, Aurora E. Serralde-Zuniga
Summary: This study evaluated the effect of 7-day supplementation of n-3 polyunsaturated fatty acids on oxidative stress in patients with Type II intestinal failure receiving parenteral nutrition. The results showed improvements in oxidative stress markers, blood lipids, and hepatic biomarkers after the supplementation.
Article
Biochemistry & Molecular Biology
Sergio Davinelli, Alessandro Medoro, Mariano Intrieri, Luciano Saso, Giovanni Scapagnini, Jing X. Kang
Summary: The transcription factor NRF2 and its endogenous inhibitor KEAP1 are important for maintaining cellular redox homeostasis. Activation of NRF2 can provide cellular protection against age-related diseases. Recent studies have identified compounds, including omega-3 polyunsaturated fatty acids (PUFAs) and their electrophilic derivatives, that may restore NRF2 function in aging cells. These findings suggest that n-3 PUFAs could be potential agents for preventing chronic diseases and restoring age-related NRF2 impairment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Food Science & Technology
Scott B. Teasdale, Skye Marshall, Kylie Abbott, Tim Cassettari, Emily Duve, Flavia Fayet-Moore
Summary: This study conducted an umbrella review to investigate the nutritional and bioactive components of commonly consumed edible oils and fats, finding strong evidence supporting the beneficial effects of high mono- and polyunsaturated fatty acid compositions, total biophenol content, and phytosterols on high-burden chronic diseases. However, insufficient evidence was found for the impact of squalene. Future dietary guidelines should consider a more comprehensive approach to evaluating edible oils beyond saturated fatty acid content.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Fabio Galvano, Sabrina Castellano, Giuseppe Grosso
Summary: This study investigated the relationship between the intake of different types of dietary fats and depressive symptoms in Italian individuals living in the Mediterranean area. The results showed a negative association between moderate intake of polyunsaturated fatty acids (PUFA) and depressive symptoms, while moderate intake of saturated fatty acids (SFA) was positively associated with depressive symptoms. Moreover, individuals with lower to moderate intake of short-chain and medium-chain saturated fatty acids had a lower risk of depressive symptoms. These findings highlight the importance of distinguishing between different fat types.
Article
Nutrition & Dietetics
Ze-Bin Fang, Gao-Xiang Wang, Gui-Zhang Cai, Peng-Xiang Zhang, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li, Hing-Xia Zhao
Summary: This study investigates the relationship between fatty acid intake and bone mineral density (BMD) in adults aged 20-59. The results reveal a significant positive correlation between the consumption of saturated fatty acids, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids and BMD.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
A. J. Hulbert
Summary: This article discusses the importance of ω-6 and ω-3 polyunsaturated fatty acids in biological membrane function, as well as their necessity and balance in animal diets. These two fatty acids have significant effects on membrane composition, thereby influencing the physiological capacities and health of animals.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Rafaela Furioso Ferreira, Thomas Blees, Farhad Shakeri, Andreas Buness, Marc Sylvester, Giovanni Savoini, Alessandro Agazzi, Vladimir Mrljak, Helga Sauerwein
Summary: This study investigates the effect of different ω-6:ω-3 ratios in the maternal diet on the milk EV proteome. EV play a crucial role in regulating the infant's immune system and growth, and any changes in the EV proteome could impact intercellular communication. This research is of significance for both basic research and applied aspects in animal nutrition and health, and may provide new insights into feeding additives.
JOURNAL OF PROTEOMICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tayse Caroline Cunha de Medeiros, Alessandra Areas e Souza, Rodolfo Coelho Prates, Iain Chapple, Joao Paulo Steffens
Summary: This study found an association between systemic non-communicable diseases and tooth loss in Brazilian adults. Risk factors such as diabetes, smoking, and a cariogenic diet were significantly related to tooth loss. Regular consumption of vegetables, fruits, and beef, moderate alcohol intake, and physical exercise were associated with a lower risk of tooth loss. Obesity and other diseases may also increase the risk of tooth loss in individuals with diabetes.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Respiratory System
Hayley Holt, Mohammad Talaei, Matthew Greenig, Dominik Zenner, Jane Symons, Clare Relton, Katherine S. Young, Molly R. Davies, Katherine N. Thompson, Jed Ashman, Sultan Saeed Rajpoot, Ahmed Ali Kayyale, Sarah El Rifai, Philippa J. Lloyd, David Jolliffe, Olivia Timmis, Sarah Finer, Stamatina Iliodromiti, Alec Miners, Nicholas S. Hopkinson, Bodrul Alam, Graham Lloyd-Jones, Thomas Dietrich, Iain Chapple, Paul E. Pfeffer, David McCoy, Gwyneth Davies, Ronan A. Lyons, Christopher Griffiths, Frank Kee, Aziz Sheikh, Gerome Breen, Seif O. Shaheen, Adrian R. Martineau
Summary: The study found that Asian/Asian British ethnicity and a higher body mass index were associated with an increased odds of developing COVID-19, while atopic disease was associated with decreased odds.
Article
Dentistry, Oral Surgery & Medicine
Melissa M. Grant, John J. Taylor, Katrin Jaedicke, Andrew Creese, Catherine Gowland, Bernard Burke, Khawla Doudin, Upen Patel, Paul Weston, Michael Milward, Susan M. Bissett, Helen J. Cooper, Gerben Kooijman, Amir Rmaile, Marko de Jager, Philip M. Preshaw, Iain L. C. Chapple
Summary: Differential protein biomarkers in saliva and gingival crevicular fluid can be used to objectively distinguish between periodontal health and disease states.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Environmental Sciences
Helen M. Roberts, Zehra Yonel, Alpdogan Kantarci, Melissa M. Grant, Iain L. C. Chapple
Summary: This study aimed to investigate the impact of experimental gingivitis on the function of peripheral blood neutrophils (PBN). The results showed that experimental gingivitis had a lasting effect on the function of neutrophils, even after clinical symptoms disappeared.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Koren Hashai, Ian L. Chapple, Lior Shapira, Walaa Assadi, Stav Dadon, David Polak
Summary: This study highlights the differences in neutrophil response to JP2 infection between periodontally healthy individuals and MIPP patients, specifically in terms of resistance to necrosis, ROS production, and cytokine levels. The findings suggest a potential role for the CD18 receptor in the periodontal susceptibility of MIPP patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Z. Yonel, T. Kocher, I. L. C. Chapple, T. Dietrich, H. Voelzke, M. Nauck, G. Collins, L. J. Gray, B. Holtfreter
Summary: The study aims to develop and validate a score in dental settings to identify individuals at risk of undiagnosed nondiabetic hyperglycemia or type 2 diabetes. The model includes several variables such as age, sex, body mass index, smoking status, and dental factors. The predictive performance and clinical utility of the model were assessed.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Paola de Pablo, Stefan Serban, Isabel Lopez-Oliva, Joanna Rooney, Kirsty Hill, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich
Summary: This study investigated the impact of periodontal treatment on disease activity in patients with active rheumatoid arthritis (RA) through a randomized controlled trial. The results showed that periodontal therapy can significantly improve periodontal disease outcomes and overall RA disease activity, although complete resolution of periodontal inflammation was difficult to achieve in some cases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Praveen Sharma, Caroline Kristunas, Iain L. Chapple, Thomas Dietrich
Summary: This study investigates the associations between periodontal health and patient-reported outcomes in a large non-specialist dental practice patient cohort, considering changes over time. The results show that worsening periodontal health is associated with increased odds of oral pain/discomfort, dietary restrictions, and poor dental appearance.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple, Soren Jepsen, Anton Sculean, Moritz Kebschull, Panos N. Papapanou, Maurizio S. Tonetti, Mariano Sanz
Summary: This study aims to develop clinical practice guidelines for the prevention and treatment of peri-implant diseases, emphasizing the need for interdisciplinary approaches and interventions at different stages. The guidelines provide recommendations for maintaining healthy peri-implant tissues and managing peri-implant diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Melissa M. M. Grant, Ann E. E. Scott, John B. B. Matthews, Helen R. R. Griffiths, Iain L. C. Chapple
Summary: Curcumin can decrease inflammatory response induced by oral bacterium and be potentially useful in treating gingivitis. Its mechanism of action involves the modulation of transcription factors and enzymes related to the inflammatory cascade.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira
Summary: Neutrophils, also called granulocytes, are myeloid cells that play a critical role in acute and chronic inflammation, as well as wound healing. They express a variety of surface receptors to facilitate their migration, recognition, and destruction of pathogens or damaged tissues. Neutrophils can undergo different forms of programmed cell death and exhibit heterogeneous behavior and biological repertoire.
PERIODONTOLOGY 2000
(2023)
Article
Dentistry, Oral Surgery & Medicine
Beant Singh Thandi, Rosemarie Jane, Vinay Chavda, Iain L. C. Chapple
Summary: This case report describes the successful diagnosis and management of a rare condition called non-ulcerating necrotising sialometaplasia, which was confounded by a simultaneous episode of pericoronitis. The importance of investigating suspicious lesions and listening to patients' complaints is emphasized.
BRITISH DENTAL JOURNAL
(2023)
Article
Infectious Diseases
Sian E. Faustini, Alex Cook, Harriet Hill, Saly Al-Taei, Jennifer Heaney, Elena Efstathiou, Chloe Tanner, Neal Townsend, Zahra Ahmed, Mohammad Dinally, Madeeha Hoque, Margaret Goodall, Zania Stamataki, Timothy Plant, Iain Chapple, Pitch Consortium, Adrian M. Shields, Alex G. Richter
Summary: This study investigated the importance of salivary SARS-CoV-2 antibodies and found that salivary antibody responses differ from serum antibody responses, typically lacking neutralizing activity. While saliva is an attractive non-invasive surveillance tool, it cannot be used as a proxy for serum antibody measurement.
JOURNAL OF INFECTION
(2023)
Review
Dentistry, Oral Surgery & Medicine
P. A. Miguez, E. Bash, M. L. Musskopf, S. A. Tuin, A. Rivera-Concepcion, I. L. C. Chapple, J. Liu
Summary: Proteoglycans are core proteins associated with highly variable carbohydrate/sugar moieties. These carbohydrates, named glycosaminoglycans, play multiple roles in inflammation, immunity, and tissue structure. Heparan sulfate, a highly sulfated polysaccharide, has been found to be involved in regulating interactions between damage associated molecular patterns and inflammatory receptors. Recent advancements in producing structurally defined heparan sulfate have provided new insights into its potential therapeutic applications for periodontitis and bone formation.
PERIODONTOLOGY 2000
(2023)
Article
Engineering, Biomedical
Thomas E. Robinson, Mathieu Y. Brunet, Iain Chapple, Adrian H. M. Heagerty, Anthony D. Metcalfe, Liam M. Grover
Summary: A novel approach using low-cost polysaccharide iota carrageenan is effective at preventing fibrotic diseases and improving quality of life. It inhibits collagen fibril formation, abrogates the TGF-beta 1 pathway, and provides lubrication. The study demonstrates the potential of self-delivering immunomodulatory polysaccharides as a safe and cost-effective platform for clinical benefit.
ADVANCED NANOBIOMED RESEARCH
(2023)