Article
Cell Biology
Caitlin C. Zebley, Hossam A. Abdelsamed, Hazem E. Ghoneim, Shanta Alli, Charmaine Brown, Dalia Haydar, Tian Mi, Tarsha Harris, Maureen A. McGargill, Giedre Krenciute, Ben Youngblood
Summary: The study found that IL-12 plays an important role in the priming of CD8 T cells, promoting TET2-mediated demethylation programming and influencing the expression of IFNg. This suggests that cytokines can guide the induction of epigenetically regulated traits in T cells.
Article
Cell Biology
Zhuo Li, Jian Liu, Huifeng Fu, Yuanwei Li, Qiang Liu, Wei Song, Mingqiang Zeng
Summary: Abnormal activation of STAT3 has been found in bladder cancer, and in our study, we discovered that SENP3 is highly expressed and regulates the activation of STAT3 through deSUMOylation. Further investigation revealed that nuclear STAT3 acts as a transcriptional factor, promoting the expression of PYCR1 gene and protein by interacting with its promoter. Silencing of PYCR1 inhibited epithelial to mesenchymal transition and mitigated the carcinogenic effects of STAT3 in bladder cancer.
Article
Cell Biology
Zhendong Liu, Zhehao Fan, Rui Wang, Xiaolei Li, Hui Chen, Jingcheng Wang
Summary: This study investigated the effect of IFN-alpha-2b on preventing postoperative arthrofibrosis in rats and its antiproliferation effect on fibroblasts in vitro, as well as its molecular mechanism. The results showed that IFN-alpha-2b significantly reduced arthrofibrosis by inhibiting fibroblast proliferation and migration, possibly through the regulation of STAT1/p21 signaling pathway.
MEDIATORS OF INFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Peng Zheng, Hengfang Wu, Yilu Gu, Luo Li, Ran Hu, Wenjing Ma, Zhiping Bian, Nannan Liu, Di Yang, Xiangjian Chen
Summary: This study investigates whether the cardiac pleiotropic effects of atorvastatin are associated with the regulation of fatty acid oxidation (FAO) through the carnitine palmitoyltransferase 1 (CPT1). The results show that atorvastatin improves mitochondrial dysfunction and cardiac hypertrophy induced by high-fat diet, and lowers CPT1 and FAO levels. It is the first study to explore the cardiac pleiotropic effects of atorvastatin with respect to FAO.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Andreas Schaefer, Muharrem Akin, Johanna Diekmann, Tobias Koenig
Summary: Optimal medical therapy for secondary prevention following acute myocardial infarction reduces non-fatal ischaemic events. Intracoronary administration of super-saturated oxygen (SSO2) immediately after revascularisation is an approach that can be used to reduce infarct size and improve cardiovascular outcome in patients with acute myocardial infarction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Zhifa Shen, Bowen Liu, Biting Wu, Hongyin Zhou, Xiangyun Wang, Jinling Cao, Min Jiang, Yingying Zhou, Feixia Guo, Chang Xue, Zai-Sheng Wu
Summary: The study proposes a mechanism for the metastasis of hepatocellular carcinoma (HCC) cells by regulating the localization and translation of the STAT3 oncogene through fragile X mental retardation protein (FMRP). Knockdown of FMRP suppresses HCC metastasis effectively.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So Jin Park, Hye Jin Jung
Summary: Bufotalin, a natural compound, exhibits antiproliferative and antimetastatic activities in triple-negative breast cancer (TNBC) cells by modulating the apoptotic pathway and the STAT3/EMT axis.
Article
Anatomy & Morphology
Wei Han, Desong Kong, Qin Lu, Wei Zhang, Zhimin Fan
Summary: The study found that Aloperine inhibited proliferation and metastasis of colorectal cancer cells, and promoted apoptosis by regulating the miR-296-5p/STAT3 axis. This provides a new research direction and opportunity for the development of treatments for colorectal cancer.
Article
Infectious Diseases
Zhao-Ming Chen, Xiao-Yun Yang, Zheng-Tu Li, Wei-Jie Guan, Ye Qiu, Shao-Qiang Li, Yang-Qing Zhan, Zi-Ying Lei, Jing Liu, Jian-Quan Zhang, Zhong-Fang Wang, Feng Ye
Summary: The presence of anti-IFN-gamma autoantibodies inhibits immune responses of CD4(+) Th1 and CD8(+) T cells, and increases the release of IL-10.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, Research & Experimental
Jiameng Lu, Xiaoqing Ji, Lixia Wang, Fei Sun, Chuanjun Huang, Haiying Peng, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Yanbo Ji, Degan Lu
Summary: This study found that prophylactic administration of IL-27 can improve asthma by restoring the STAT1 and STAT3 pathways, alleviating the Th2 inflammatory environment in the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Michaela Oeller, Heidi Jaksch-Bogensperger, Markus Templin, Renate Gehwolf, Eva Rohde, Katharina Schallmoser, Sandra Laner-Plamberger
Summary: This study investigated the effect of human platelet lysate (HPL) on cell cycle gene expression in human stromal cells. The results showed that HPL can enhance cell proliferation by upregulating the expression of STAT3 and MYC, which are downstream effectors of tyrosine kinase receptor (TKR) pathways. This finding provides valuable insights into the molecular mechanism of HPL's growth-enhancing effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: Persistent activation of signal transducer and activator of transcription 3 (STAT3) via interleukin-6 (IL-6) trans-signaling is involved in fibrosis of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Chemistry, Medicinal
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Jiangnan Ye, Huang Chen, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi, Yihua Chen
Summary: This study describes the design, synthesis, and structure-activity relationship studies of triaromatic heterocyclic derivatives as potent dual phosphorylation STAT3 inhibitors. The best compound 3h (HP590) was discovered with high inhibitory activity against p-Tyr(705) and p-Ser(727), resulting in the growth inhibition of gastric cancer both in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Qian-zhi Chen, Yan Chen, Xia Li, Hao Liu, Xu-ling Sun
Summary: The study found that TRIB3 is significantly increased in colon cancer tissues compared to normal tissues, and elevated TRIB3 expression indicates a poor prognosis in colon cancer patients. Silencing TRIB3 can inhibit cancer angiogenesis, while overexpressing TRIB3 can promote cancer angiogenesis. TRIB3 cooperates with STAT3 to increase VEGFA expression, thereby affecting cancer angiogenesis.
CURRENT MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
William B. Orr, Mark C. Johnson, Aaron M. Abarbanell, Marc Sintek
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Pediatrics
Connor P. Callahan, Taylor C. Merritt, Matthew W. Canter, Pirooz Eghtesady, Peter B. Manning, Aaron M. Abarbanell
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Engineering, Biomedical
Matthew R. Schill, Matthew T. Douds, Emily L. Burns, Michael A. Lahart, Ahmed S. Said, Aaron M. Abarbanell
Summary: This retrospective study compared the outcomes of children on ECLS anticoagulated with bivalirudin versus heparin, finding no significant differences in circuit interventions, blood product transfusions, survival to decannulation, or survival to discharge between the two groups. However, a longer freedom from first circuit intervention was observed in the bivalirudin group. Larger studies are needed to determine the optimal anticoagulation strategy for this complex and diverse group of children.
Editorial Material
Cardiac & Cardiovascular Systems
Jeremy L. Herrmann
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Review
Surgery
John P. Costello, Horacio G. Carvajal, Aaron M. Abarbanell, Pirooz Eghtesady, Dilip S. Nath
Summary: Lung transplantation in infants presents unique challenges due to the scarcity of data in this age group compared to older children and adults. Recent advances in bridge-to-transplantation therapy and differences in surgical techniques have been studied to provide the best care for infant patients undergoing lung transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Pediatrics
Robert M. MacGregor, Nicole A. Wilson, Baddr A. Shakhsheer, Martin S. Keller, Patrick A. Dillon, Aaron M. Abarbanell
Summary: Pediatric tumors in the apex of the thoracic cavity are often diagnosed late due to the absence of symptoms. Surgical resection of these large tumors may involve an extended sternotomy with a lateral neck incision to achieve optimal exposure. Different techniques, including both anterior and posterior thoracic approaches, have been described, but may have limitations in exposing the mass adequately.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Subhjit Sekhon, Philip M. Barger, Aaron M. Abarbanell
Summary: Two women underwent pulmonary valvotomy for PVS as young children and subsequently underwent uncomplicated open pulmonary valve replacement over 60 years later, with the longest-known published follow-up.
JOURNAL OF CARDIAC SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Jeremy L. Herrmann
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Parth M. Patel, Jeremy L. Herrmann, Eric Bain, Joseph M. Ladowski, Cameron Colgate, Mark D. Rodefeld, Mark W. Turrentine, John W. Brown
Summary: The timing and nature of reoperations after arterial switch operation in patients with d-transposition of the great arteries need further clarification. Techniques like pantaloon patch pulmonary artery reconstruction and intermittent neo-aortic root distension have shown to minimize specific reoperations. Certain anatomic subsets carry different risks for late reoperation, highlighting the importance of targeted attention to high-risk subpopulations for optimizing lifelong outcomes.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Jeremy L. Herrmann
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
Michael A. Lahart, Emily L. Burns, Madison M. Streb, Hongjie Gu, Tara M. Neumayr, Aaron M. Abarbanell, Ahmed S. Said
Summary: There is limited information on the dosing of bivalirudin in pediatric ECMO patients requiring CRRT. This study found no difference in bivalirudin dosing between pediatric ECMO patients who required CRRT and those who did not. Younger age and lower weight were associated with higher bivalirudin dosing.
Article
Cardiac & Cardiovascular Systems
Caleb R. Matthews, Dana Hartman, Anne G. Farrell, Cameron L. Colgate, Brian W. Gray, Kirsten Zborek, Jeremy L. Herrmann
Summary: Nutritional management and home monitoring programs, along with early feeding gastrostomy tube (GT) placement, may be beneficial for improving interstage morbidity and mortality in patients with hypoplastic left heart syndrome (HLHS). These interventions have shown to optimize somatic growth and provide a reliable mode of nutritional support, especially for high-risk patients.
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin J. Landis, Benjamin M. Helm, Jeremy L. Herrmann, Madeline C. Hoover, Matthew D. Durbin, Lindsey R. Elmore, Manyan Huang, Michael Johansen, Ming Li, Leon F. Przybylowski, Gabrielle C. Geddes, Stephanie M. Ware
Summary: This study found that routine genetic evaluations and chromosomal microarray (CMA) testing can help stratify mortality risk in severe congenital heart disease. Genetic abnormalities were associated with prematurity, extracardiac anomaly, and lower weight at surgery. However, CMA abnormalities were not associated with postoperative length of hospitalization, extracorporeal membrane oxygenation, or extubation time.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Christopher W. Mastropietro, Andrea B. Clark, Katie L. Loke, Paulomi Chaudhry, Anne E. Cossu, Jyoti K. Patel, Jeremy L. Herrmann
Summary: Objective: The study aimed to identify factors associated with the use of inotropic support after pulmonary artery banding surgery for CHD. Results: Inotropic support was administered in approximately half of the patients who underwent the surgery, and the main factor associated with its use was a cumulative ketamine dose greater than 2.5mg/kg. Conclusion: This finding has significant implications for improving the clinical management of the surgery.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy L. Herrmann, Aaron J. Clark, Cameron Colgate, Mark D. Rodefeld, Mark H. Hoyer, Mark W. Turrentine, John W. Brown
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2020)