Review
Infectious Diseases
Mohd Zulkifli Salleh, Nik Mohd Noor Nik Zuraina, Khalid Hajissa, Mohamad Ikram Ilias, Kirnpal Kaur Banga Singh, Zakuan Zainy Deris
Summary: Shigellosis remains a major cause of morbidity and mortality worldwide, and the emergence of antimicrobial-resistant strains poses a significant challenge in its treatment. This systematic review and meta-analysis provide an updated picture of the prevalence of antimicrobial-resistant Shigella species in Asia. The study found that multidrug-resistant and extended-spectrum beta-lactamase-producing Shigella strains are prevalent among Asian patients.
Article
Chemistry, Analytical
Manal Suleiman, George Abu-Aqil, Uraib Sharaha, Klaris Riesenberg, Orli Sagi, Itshak Lapidot, Mahmoud Huleihel, Ahmad Salman
Summary: Rapid detection of ESBL+ bacteria is crucial for efficient treatment of bacterial infections. Results from the study demonstrate the possibility of accurately identifying ESBL+ Klebsiella pneumoniae within about 20 minutes, with approximately 89% accuracy, sensitivity, and specificity.
Article
Infectious Diseases
Agata Pruss, Pawel Kwiatkowski, Helena Masiuk, Iwona Bilska, Stefania Giedrys-Kalemba, Barbara Dolegowska
Summary: This study describes the successful containment and elimination of an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal ward. Through testing 26 neonates and 42 environmental swabs, it was confirmed that 18 neonates were colonized with ESBL-KP and developed infections. Strengthening hospital hygiene protocols, screening of hospitalized neonates, and cohorting ESBL-KP-positive patients proved effective in controlling and ending the outbreak.
Article
Microbiology
Hidenori Yamashiro, Yu Kasamatsu, Naomi Anan, Miki Takemura, Yoshinori Yamano
Summary: This study compared the efficacy of flomoxef with other beta-lactam antibiotics against extended-spectrum beta-lactamases (ESBL)-producing bacteria of clinical relevance. The results demonstrated that flomoxef showed good bactericidal effects and effectively inhibited the growth of ESBL-producing strains, even those with a high minimum inhibitory concentration (MIC) value. Therefore, flomoxef may be a promising alternative in the context of carbapenems sparing stewardship.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Public, Environmental & Occupational Health
H. Namikawa, W. Imoto, K. Yamada, Y. Tochino, Y. Kaneko, H. Kakeya, T. Shuto
Summary: This review evaluated 10 observational studies and found that previous antibiotic therapy, especially with cephalosporins and quinolones, as well as urinary catheter use, were predictive factors for ESBL-producing E. coli-induced bacteraemia.
JOURNAL OF HOSPITAL INFECTION
(2023)
Review
Infectious Diseases
Weiping Ling, Anna Maria Peri, Luis Furuya-Kanamori, Patrick N. A. Harris, David L. Paterson
Summary: This systematic review and meta-analysis aimed to estimate the duration of ESBL-E carriage in the community and the rate of household transmission. The results showed that approximately 22% of patients still carried ESBL-E after 12 months, and travelers had significantly shorter carriage time. The data on household transmission were insufficient for robust analysis, but longitudinal studies suggested that 18.4% to 35.2% of contacts acquired ESBL-E within 4 to 36 months after patient discharge.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Se Ra Shin, Seong Mi Noh, Woo Kyung Jung, Sook Shin, Young Kyung Park, Dong Chan Moon, Suk-Kyung Lim, Yong Ho Park, Kun Taek Park
Summary: The study conducted in South Korea between 2017 and 2019 identified various ESC-resistant bacterial isolates in companion animals, with predominant species being E. coli, Klebsiella, and others. These isolates displayed diversity in sequence types and resistance genes.
Article
Immunology
F. Morales-Leon, A. Opazo-Capurro, C. Caro, N. Lincopan, A. Cardenas-Arias, F. Esposito, V. Illesca, M. L. Rioseco, M. Dominguez-Yevenes, C. A. Lima, H. Bello-Toledo, Gerardo Gonzalez-Rocha
Summary: The convergence of virulence and multidrug-resistant phenotype is reported for the first time in Chile in Klebsiella pneumoniae complex isolates, indicating a clinical problem that requires special attention and continuous surveillance in South America. The detected hypervirulent isolates displayed resistance to broad-spectrum cephalosporins and carried multiple antibiotic-resistance genes, leading to a multidrug-resistant phenotype. In vivo virulence testing confirmed higher virulence of the isolates compared to the control strain.
Review
Infectious Diseases
Olivier Del Corpo, Julien Senecal, Jimmy M. Hsu, Alexander Lawandi, Todd C. Lee
Summary: This study investigated the performance of rapid phenotypic tests applied directly to positive blood cultures. The results showed that these tests have high sensitivity and specificity, indicating their potential role in clinical practice.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Microbiology
Shweta R. Singh, Alvin Kuo Jing Teo, Kiesha Prem, Rick Twee-Hee Ong, Elizabeth A. Ashley, H. Rogier van Doorn, Direk Limmathurotsakul, Paul Turner, Li Yang Hsu
Summary: Despite limited knowledge on the prevalence of ESBL-E and CPE in the Greater Mekong Subregion, recent trends show an increase in ESBL-producing E. coli in clinical and carriage specimens. Risk factors associated with ESBL-E isolation include recent antibiotic exposure, chronic kidney disease, and other co-morbidities. Collaboration on standardizing study methods is needed to improve monitoring and surveillance in the region, especially in community settings of Laos, Myanmar, Cambodia, and Yunnan and Guangxi provinces of China.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Daniel Martak, Julia Guther, Tess D. Verschuuren, Benoit Valot, Nadine Conzelmann, Stefanie Bunk, M. Eugenia Riccio, Elena Salamanca, Alexandre Meunier, Charles P. Henriot, Caroline Pressacco Brossier, Xavier Bertrand, Ben S. Cooper, Stephan Harbarth, Evelina Tacconelli, Ad C. Fluit, Jesus Rodriguez-Bano, Jan A. J. W. Kluytmans, Silke Peter, Didier Hocquet
Summary: This study in five European cities found that food items were not the main source of ESBL-Ec and ESBL-Kp, as the strains from contaminated environments were genetically distinct from those in food. The findings suggest that human-to-human transmission is possibly the most frequent route of ESBL-Ec and ESBL-Kp transmission in high-income countries.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Immunology
Hiroki Namikawa, Waki Imoto, Koichi Yamada, Yoshihiro Tochino, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto
Summary: This systematic review and meta-analysis identified predictors of mortality from extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) bacteremia. Previous antimicrobial therapy, neutropenia, nosocomial infection, rapidly fatal underlying disease, respiratory tract infection, Pitt bacteremia score, severe sepsis, and urinary tract infection were found to be predictors of mortality. Appropriate empirical therapy was identified as a protective factor against mortality.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Veterinary Sciences
Xiaoyan Su, Xia Yan, Yunli Li, Dongsheng Zhang, Lin Li, Yi Geng, Fei Su, Chanjuan Yue, Rong Hou, Songrui Liu
Summary: This study characterized ESBL-producing Klebsiella pneumoniae strains in captive giant pandas, finding different ESBL-encoding genes and antimicrobial resistance genes in these isolates. The strains were resistant to multiple antibiotics and belonged to different sequence types. Effective surveillance and strict infection control strategies are necessary to prevent outbreaks of ESBL-producing Klebsiella pneumoniae in giant pandas.
BMC VETERINARY RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
I Nakamura, T. Yamaguchi, Y. Miura, H. Watanabe
Summary: This study investigated the transmission of ESBL-producing Klebsiella pneumoniae strains from sinks and drains in a general surgical hospital ward. Through whole-genome analysis, it was found that the isolates were indistinguishable genetically, confirming this mode of transmission.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Immunology
Jun Sakai, Shigefumi Maesaki
Summary: This study aimed to distinguish ESBL-producing K. quasipneumoniae (ESBL-KQ) and ESBL-producing K. variicola (ESBL-KV) from ESBL-producing K. pneumoniae (ESBL-KP) in terms of frequency, genomic characteristics, and antimicrobial susceptibility patterns. The study found that ESBL-KQ and ESBL-KP had different gene profiles, and the prevalence of antimicrobial resistance via AmpC and fluoroquinolone-resistance genes increased in ESBL-KQ.
MICROBIAL PATHOGENESIS
(2022)
Article
Gastroenterology & Hepatology
Arjan W. Rauwers, Anne F. Voor in't Holt, Jolanda G. Buijs, Woutrinus de Groot, Nicole S. Erler, Margreet C. Vos, Marco J. Bruno
Summary: Post-manual cleaning ATP tests do not reduce gut flora contamination rates of DLEs and are not suitable for quality control of endoscope reprocessing.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Public, Environmental & Occupational Health
Adrienne S. van der Schoor, Juliette A. Severin, Anna S. van der Weg, Nikolaos Strepis, Corne H. W. Klaassen, Johannes P. C. van den Akker, Marco J. Bruno, Johanna M. Hendriks, Margreet C. Vos, Anne F. Voor In 't Holt
Summary: Transitioning to 100% single-occupancy rooms did not decrease ESBL-E acquisition, but did significantly decrease the number of intra-hospital patient transfers. The latter was associated with lower odds on ESBL-E acquisition. ESBL-E carriers remained largely unidentified through clinical samples.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Thi Mui Pham, Andrea C. Buchler, Anne F. Voor In 't Holt, Juliette A. Severin, Martin C. J. Bootsma, Diederik Gommers, Mirjam E. Kretzschmar, Margreet C. Vos
Summary: This study analyzed VIM-PA surveillance data of two intensive-care unit (ICU) wards in Erasmus University Medical Center Rotterdam from 2010 to 2018 using a mathematical transmission model. The results showed that the majority of VIM-PA transmissions in these ICUs were caused by persistent environmental contamination, while only a small proportion were due to direct cross-transmission.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Letter
Public, Environmental & Occupational Health
Andrea C. Buchler, Anne F. Voor In't Holt
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Daphna Hoefnagel, Victor Volovici, Ellianne dos Santos J. Rubio, Anne Voor In't F. Holt, Clemens M. F. Dirven, Margreet C. Vos, Ruben Dammers
Summary: External ventricular drainage (EVD) is commonly used in neurosurgical procedures for cerebrospinal fluid drainage, but it is associated with high infection rates. This study aimed to measure the effect of a hospital-wide EVD handling protocol on the incidence of secondary EVD infections.
Article
Public, Environmental & Occupational Health
J. A. Kwakman, M. C. Vos, M. J. Bruno
Summary: This study compared culturing results of duodenoscope samples collected with and without addition of a neutralizer. It found that adding a neutralizer increased the yield of cultures from wet duodenoscope samples, while samples without a neutralizer had higher yield after drying. Standardization of the sampling method can help compare clinical and study results regarding duodenoscope contamination.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Public, Environmental & Occupational Health
M. J. Sarink, W. A. van Cappellen, A. G. M. Tielens, A. van Dijk, A. J. J. C. Bogers, J. E. M. de Steenwinkel, M. C. Vos, J. A. Severin, J. J. van Hellemond
Summary: The presence of V. vermiformis in water-based heater-cooler units can contribute to the persistent presence of M. chimaera. Cleaning and disinfection protocols should take this phenomenon into account.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Indri Rooslamiati Supriadi, Cynthia P. Haanappel, Leli Saptawati, Nani H. Widodo, Gortap Sitohang, Yuslely Usman, Ida Bagus Anom, Ratih Dian Saraswati, Michal Heger, Pieter A. Doevendans, Hindra Irawan Satari, Anne Voor F. In 't Holt, Juliette A. Severin
Summary: This study aimed to assess the implementation of infection prevention and control (IPC) in hospitals in Indonesia using the WHO IPC assessment framework tool (IPCAF) and to identify strengths, gaps, and challenges. The majority of Indonesian hospitals were assessed as having advanced IPC levels, but the distribution was uneven across the country. Challenges were mainly related to communication with hospital management, lack of adequate microbiology laboratory capacity to support infection surveillance, and insufficient staffing of full-time IPC nurses.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Infectious Diseases
Linda J. J. Wammes, Anne F. Voor in F. 't Holt, Corne H. W. Klaassen, Margreet C. C. Vos, Nelianne J. J. Verkaik, Juliette A. Severin
Summary: This study aimed to improve the sensitivity of detecting vancomycin-resistant Enterococcus faecium (VRE) transmission and determine the time from presumed exposure to detectable colonization. Retrospective analysis of 9 VRE outbreaks showed that using the first three out of five rectal swabs identified 89% of all secondary cases, compared to only 64% with the first swab. In addition, taking one or more rectal swabs around day 9 after presumed exposure was found to be the most effective screening approach.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Adrienne S. van der Schoor, Juliette A. Severin, Corne H. W. Klaassen, Diederik Gommers, Marco J. Bruno, Johanna M. Hendriks, Anne F. Voor in 't Holt, Margreet C. Vos
Summary: This study aimed to compare the environmental contamination with highly resistant microorganisms (HRMO) between an old hospital building and a new hospital building, and to investigate the environmental contamination in the new building after relocation. The results showed a significant decrease in HRMO contamination in the new building, which is important for hospital design and construction considerations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Jannette Pirzadian, Anne F. Voor In 't Holt, Mehjabeen Hossain, Corne H. W. Klaassen, Inge de Goeij, Heidy H. H. T. Koene, Lonneke G. M. Bode, Margreet C. Vos, Juliette A. Severin
Summary: In healthcare environments, sinks are recognized as reservoirs for multidrug-resistant bacteria. This study implemented an intervention to install sink drain plugs as barriers against transmission of VIM-PA from drain reservoirs. Results showed a significant reduction in VIM-PA positivity after the intervention, but recolonization was observed over time.
Review
Public, Environmental & Occupational Health
Andrea C. Buchler, Selvi N. Shahab, Juliette A. Severin, Margreet C. Vos, Anne F. Voor In ' T. Holt
Summary: This systematic review aimed to summarize outbreak investigations (OI) performed after the detection of carbapenem-resistant Pseudomonas aeruginosa (CRPA) in healthcare settings. The study found significant variations in the components of OI in both epidemic and endemic settings. Further research is needed to develop guidance on when and how to best perform OI.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Multidisciplinary Sciences
Adrienne S. van der Schoor, Juliette A. Severin, Corne H. W. Klaassen, Johannes P. C. van den Akker, Marco J. Bruno, Johanna M. Hendriks, Margreet C. Vos, Anne F. Voor F. In 't Holt
Summary: Timely identification of patients carrying multidrug-resistant microorganisms is crucial to prevent nosocomial spread. This study compared the yield of a universal screening strategy upon admission to the current risk assessment combined with risk-based screening, showing that universal screening identified significantly more carriers in a low endemic setting.
