Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Marie C. Conway, Emeir M. McSorley, Maria S. Mulhern, Toni Spence, Edwin van Wijngaarden, Gene E. Watson, Karin Wahlberg, Daniela Pineda, Karin Broberg, Barry W. Hyland, Diego F. Cobice, J. J. Strain, Alison J. Yeates
Summary: The study found that consuming two portions of fish per week significantly increased concentrations of EPA, DHA, and total n-3 PUFA in women of childbearing age, with a lower n-6:n-3 ratio compared to those consuming no fish or one portion per week. However, fish consumption did not have a significant effect on biomarkers of oxidative stress, inflammation, and lipid profile in the current study.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Fisheries
Michail I. Gladyshev, Alexander A. Makhrov, Nadezhda N. Sushchik, Olesia N. Makhutova, Anastasia E. Rudchenko, Dmitrii A. Balashov, Evgenii V. Vinogradov, Valentina S. Artamonova
Summary: This study examined the composition and contents of fatty acids (FA) in fillets of seven strains of rainbow trout. The results showed that the diet composition and genetics played a role in the FA composition of the fish. The Steelhead strain of rainbow trout demonstrated a higher ability to regulate its FA composition, particularly regarding the important acids EPA and DHA. Furthermore, FA markers were identified that can be used to differentiate between wild and farmed rainbow trout.
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Nutrition & Dietetics
Maja Tomczyk, Jeffery L. Heileson, Miroslaw Babiarz, Philip C. Calder
Summary: Fatty fish and certain species of algae are the only natural sources of EPA and DHA, which have various beneficial effects for athletes. Due to limited intake and fluctuating content, athletes may consider using supplements to ensure sufficient EPA and DHA levels.
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Review
Biochemistry & Molecular Biology
Lucia Mendez, Isabel Medina
Summary: Polyphenols and omega-3 polyunsaturated fatty acids from fish oils are well-known nutraceuticals that, when combined, can increase antioxidant capacity and reduce inflammation, potentially preventing and alleviating various metabolic diseases.
Article
Medicine, General & Internal
Thomas Andersen Rix, Pia Dinesen, Soren Lundbye-Christensen, Albert Marni Joensen, Sam Riahi, Kim Overvad, Erik Berg Schmidt
Summary: The study showed a monotonous inverse association between the content of EPA in adipose tissue and the risk of AF in both men and women. The content of DHA was inversely associated with the risk of AF in women, whereas no clear association was found for men.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Xiaofang Dao, Dawei Zhang, Linlin Wang, Lina Wang
Summary: This study evaluated the fatty acid (FA) composition in the milk of lactating Tibetan women and the consequences of dietary patterns. The milk was found to have high levels of total saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) compared to milk from other regions in China. However, total polyunsaturated fatty acids (PUFA) were slightly lower, and the concentration of docosahexaenoic acid (DHA) was significantly lower. The main n-3 FAs in human milk, including DHA and EPA, may be influenced by carbohydrate intake.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Xiao-Man Sun, Ying-Shuang Xu, He Huang
Summary: Thraustochytrids can accumulate high biomass and lipid content, exhibit broad substrate utilization capacity and effective metabolic pathways without genetic modification, showing great promise for future development.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Li, Meiru Mao, Jiacheng Li, Ziteng Chen, Ying Ji, Jianglong Kong, Zhijie Wang, Jiaxin Zhang, Yujiao Wang, Wei Liang, Haojun Liang, Linwen Lv, Qiuyang Liu, Ruyu Yan, Hui Yuan, Kui Chen, Yanan Chang, Guogang Chen, Gengmei Xing
Summary: This study assessed the effects of omega-3 fatty acids on alleviating inflammation and lung injury induced by PM2.5 inhalation exposure. It was found that oral administration of DHA and EPA effectively restored normal inflammatory cytokine levels and reduced lung parenchymal lesions in mice exposed to PM2.5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Sport Sciences
Jon-Kyle Davis, Eric C. Freese, Anthony S. Wolfe, Steven A. Basham, Kimberly M. W. Stein
Summary: The study evaluated the omega-3 PUFA blood concentrations, dietary, and supplement intake of 119 professional basketball players, with many players having insufficient fish consumption per week and only a few players supplementing with omega-3 PUFA.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Nutrition & Dietetics
Tomoaki Okada, Toru Miyoshi, Masayuki Doi, Kosuke Seiyama, Wataru Takagi, Masahiro Sogo, Kazumasa Nosaka, Masahiko Takahashi, Keisuke Okawa, Hiroshi Ito
Summary: This study aimed to retrospectively investigate the 10-year trend of changes in polyunsaturated fatty acids in patients with acute coronary syndrome, revealing a secular decreasing trend in EPA and DHA levels, but not in AA and DGLA levels. The decreasing trend in EPA and DHA levels was not age-dependent and remained significant only in men, highlighting the need for further research on the effects of n-3 PUFAs on secondary prevention of ACS.
Article
Nutrition & Dietetics
Adam H. Metherel, Maha Irfan, Raphael Chouinard-Watkins, Marc-Olivier Trepanier, Ken D. Stark, Richard P. Bazinet
JOURNAL OF NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Juan J. Aristizabal-Henao, Maria F. Fernandes, Robin E. Duncan, Ken D. Stark
Article
Multidisciplinary Sciences
Marie N. Teisen, Janni Niclasen, Stine Vuholm, Jesper Lundbye-Jensen, Ken D. Stark, Camilla T. Damsgaard, Svend S. Geertsen, Lotte Lauritzen
Article
Nutrition & Dietetics
Stine Vuholm, Jesper M. Rantanen, Marie N. Teisen, Ken D. Stark, Christian Molgaard, Jeppe H. Christensen, Lotte Lauritzen, Camilla T. Damsgaard
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Adam H. Metherel, William S. Harris, Liu Ge, Robert A. Gibson, Raphael Chouinard-Watkins, Richard P. Bazinet, Lei Liu, J. Thomas Brenna, Juan J. Aristizabal-Henao, Ken D. Stark, Robert C. Block
Article
Nutrition & Dietetics
Camilla T. Damsgaard, Stine Vuholm, Marie N. Teisen, Ken D. Stark, Lotte Lauritzen
Summary: This study investigated the association between FADS gene polymorphisms and blood lipids, insulin, and glucose levels, as well as the potential modifying effects of PPARG2 genotype on n-3 LCPUFA. The findings suggest that FADS genotypes may beneficially affect children's cardiometabolic profile in a partly APOE-dependent manner. Additionally, the degree to which children benefit from higher n-3 LCPUFA intake may depend on their PPARG2 genotype.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Hugues Beaufrere, Sara M. Gardhouse, R. Darren Wood, Ken D. Stark
Article
Nutrition & Dietetics
Megan Racey, Amanda MacFarlane, Susan E. Carlson, Ken D. Stark, Melanie Plourde, Catherine J. Field, Allison A. Yates, George Wells, Andrea Grantham, Richard P. Bazinet, David W. L. Ma
Summary: The Canadian Nutrition Society organized a 1-day workshop in late 2019 for stake-holders to discuss the development of Dietary Reference Intakes based on chronic disease risk reduction and recent research, with a focus on the evidence for EPA and DHA related to cardiovascular disease risk and early development.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Bjorn Lundbergh, Ann Sofi Enevoldsen, Ken D. Stark, Christian Ritz, Lotte Lauritzen
Summary: This study found that fish oil may improve attention and working memory in adults with autism spectrum disorder (ASD) and ameliorate ADHD symptoms in those with comorbid ADHD, but did not show any effects on ASD symptoms. Compliance with fish oil supplementation correlated with whole-blood n-3LCPUFA levels and led to improvements in cognitive functions.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Veterinary Sciences
Hugues Beaufrere, Ken D. Stark, R. Darren Wood
Summary: By studying the effects of a cholesterol diet and a fat diet on Quaker parrots, it was found that the cholesterol diet induced significant dyslipidemic changes, while the fat diet did not. This study is important for further research on lipid disorders and their management in psittacine birds.
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ryan M. Bradley, Ashkan Hashemi, Juan J. Aristizabal-Henao, Ken D. Stark, Robin E. Duncan
Summary: It was discovered that PLAAT1 possesses transacylase activity for phosphatidylcholine:monolysocardiolipin, localizes mainly to the endoplasmic reticulum, and increases the levels of total cardiolipin in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
John Z. Chan, Maria F. Fernandes, Klaudia E. Steckel, Ryan M. Bradley, Ashkan Hashemi, Mishi R. Groh, German Sciaini, Ken D. Stark, Robin E. Duncan
Summary: This study compared the growth characteristics and mitochondrial morphology of lymphoblast cell lines from Barth syndrome (BTHS) patients and healthy controls, and evaluated the therapeutic potential of OEA and LEA. The findings showed that BTHS lymphoblasts grew more slowly and had abnormal mitochondrial morphology, while treatment with OEA partially restored mitochondrial function. These results suggest that mitochondrial dynamics play an important role in the pathology and treatment of BTHS.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Jessica Aymen, Pauline Delnatte, Hugues Beaufrere, Dan Chalil, Klaudia E. Steckel, Sarra Gourlie, Ken D. Stark, Malcolm McAdie
Summary: This study investigated the differences in lipid metabolism between wild and captive populations of Vancouver Island marmots. The results showed that captive marmots had higher concentrations of fatty acids and alpha-tocopherol, while wild marmots had higher levels of n-3 PUFAs and the HUFA score.
Article
Biochemistry & Molecular Biology
Daniel M. Lamontagne-Kam, Saeideh Davari, Juan J. Aristizabal-Henao, Seungjae Cho, Dan Chalil, John G. Mielke, Ken D. Stark
Summary: Recent studies suggest that the effects of DHA supplementation on human memory may differ between females and males during different life stages, but the underlying mechanisms are unclear. This study aimed to investigate the effects of a DHA-enriched diet on spatial memory and brain lipid profiles in adolescent rats of both genders. The results showed that female rats benefited more from DHA supplementation in terms of spatial memory, and lipidomic analyses revealed differences in hippocampal phospholipid species between DHA-supplemented and control animals. Understanding the sex-specific effects of DHA supplementation during perinatal and adolescent periods is important for determining dietary requirements. This study provides further evidence for the importance of DHA in spatial memory and emphasizes the need for future research on sex-specific changes caused by DHA supplementation.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2023)
Article
Nutrition & Dietetics
Sanne Sigh, Lotte Lauritzen, Frank T. Wieringa, Arnaud Laillou, Chhoun Chamnan, Ken D. Stark, Nanna Roos
Summary: This study aimed to investigate the change in whole-blood PUFA levels and nutrition and health markers among Cambodian children with severe acute malnutrition (SAM) after treatment with ready-to-use therapeutic foods (RUTFs). Results showed that RUTFs with fish-based ingredients had higher levels of n-3 PUFA, AA, and DHA, while milk-based RUTFs had higher levels of n-6 PUFA. The study found that the currently recommended composition of RUTFs may not be able to correct the compromised essential fatty acid status of children with SAM. Rating: 8/10
CLINICAL NUTRITION
(2023)