Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alan Siegel, Dagmar Hoegemann Savellano
Summary: A 62-year-old man with a history of allergic rhinitis and lightheadedness was admitted after an episode of sustained ventricular tachycardia detected by Holter monitor. A chest CT revealed peribronchial nodules, and mediastinal and hilar lymphadenopathy. MRI and FDG PET/CT confirmed the diagnosis of isolated cardiac sarcoidosis of the right ventricle, which is extremely rare.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Claudine Regis, Khadija Benali, Francois Rouzet
Summary: Sarcoidosis is a granulomatous disease of unknown origin that affects multiple systems. Diagnosis can be made through histological identification of non-caseous granulomas or a combination of clinical criteria. Treatment is often necessary to alleviate symptoms and prevent permanent organ dysfunction, particularly in cases of cardiac sarcoidosis. FDG-PET/CT and FDG-PET/MR have emerged as important imaging techniques for the diagnosis, staging, and guiding of biopsies in sarcoidosis. These imaging modalities can identify active inflammatory granulomas and serve as prognostic and therapeutic tools. This review highlights the critical roles of hybrid PET imaging in sarcoidosis and discusses potential future developments using other radiotracers and artificial intelligence applications.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Suzanne J. M. Tol, Friso M. van der Zant, Remco J. J. Knol, Maurits Wondergem, Wouter A. M. Broos
Summary: This article reports a case of Lofgren syndrome, which was visualized by F-18-FDG PET/CT showing typical thoracic lymphadenopathy, subcutaneous lesions, and periarticular FDG accumulation. The importance of recognizing and discriminating Lofgren syndrome from classic sarcoidosis is emphasized.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Evyn Arnfield, David A. Pattison
Summary: A 69-year-old woman presented with symptomatic hypercalcemia and deranged liver function. Imaging studies showed intense activity in the liver parenchyma, which was later confirmed to be hepatic sarcoidosis through MRI and liver biopsy.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Roxana Campisi, Maria Fernanda Merani, Marina Rodriguez
Summary: Cardiac sarcoidosis (CS) is an inflammatory disease that can be evaluated using cardiac metabolic imaging. [F-18]FDG PET is considered the gold standard for identifying myocardial inflammation, while [I-123]BMIPP SPECT can uncover early myocardial damage and advanced stages of the disease. The complementary role of cardiac metabolic imaging by [F-18]FDG PET and BMIPP SPECT has been proposed to detect the entire spectrum of CS.
CURRENT CARDIOLOGY REPORTS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Robert J. O'Shea, Chris Rookyard, Sam Withey, Gary J. R. Cook, Sophia Tsoka, Vicky Goh
Summary: Radiomic models offer potential for improving the assessment of oesophageal adenocarcinoma through quantitative medical image analysis. However, the selection and generalizability of these models remain challenges. Although radiomic models show promise in predicting and distinguishing clinical features of oesophageal adenocarcinoma, further improvements in sensitivity and generalizability are needed. Future research should prioritize the prospective validation of proposed models to facilitate their clinical translation.
INSIGHTS INTO IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Joao Borges-Rosa, Manuel Oliveira-Santos, Rodolfo Silva, Andreia Gomes, Jose de Almeida, Gracinda Costa, Lino Goncalves, Maria Joao Ferreira
Summary: In patients with biopsy-proven sarcoidosis, cardiac involvement detected by [18F]FDG-PET or CMR is associated with a higher risk of cardiovascular events, regardless of symptoms. Patients with probable CS had a higher prevalence of heart failure, atrial fibrillation, coronary disease, and valvular disease compared to those without cardiac involvement. Probable CS patients had significantly higher rates of heart failure hospitalizations, uncontrolled arrhythmias, and pacemaker implantation during follow-up, with a trend towards increased all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sarah Algodayan, Dimitrios Priftakis, Francesco Fraioli, Jamshed Bomanji
Summary: This report presents a case of sarcoidosis involving the epididymis in a young adult male, and discusses the usefulness of FDG PET imaging in diagnosis and assessing treatment response.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthew Aitken, Malcolm Davidson, Michael Chan, Camila Urzua Fresno, Leon I. Vasquez, Ya R. Huo, Brylie J. McAllister, Jordi Broncano, Paaladinesh Thavendiranathan, Matthew D. F. McInnes, Mark R. Iwanochko, Meyer Balter, Yasbanoo Moayedi, Ashley Farrell, Kate Hanneman
Summary: There is no consensus on the prognostic value of cardiac MRI and FDG PET in cardiac sarcoidosis. A systematic review and meta-analysis found that left and right ventricular late gadolinium enhancement at cardiac MRI and fluorodeoxyglucose uptake at PET were predictive of major adverse cardiac events in cardiac sarcoidosis.
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthew Aitken, Michael Vinchill Chan, Camila Urzua Fresno, Ashley Farrell, Nayaar Islam, Matthew D. F. McInnes, Mark Iwanochko, Meyer Balter, Yasbanoo Moayedi, Paaladinesh Thavendiranathan, Ur Metser, Patrick Veit-Haibach, Kate Hanneman
Summary: This study compared the diagnostic accuracy of cardiac MRI and FDG PET for cardiac sarcoidosis. The results showed that cardiac MRI had higher sensitivity than FDG PET, but similar specificity.
Article
Cardiac & Cardiovascular Systems
Atsushi Yamamoto, Michinobu Nagao, Eri Watanabe, Yasutaka Imamura, Atsushi Suzuki, Kenji Fukushima, Kiyoe Ando, Risako Nakao, Akiko Sakai, Mitsuru Momose, Shuji Sakai, Nobuhisa Hagiwara
Summary: The study analyzed FDG-PET and BMIPP SPECT results for cardiac sarcoidosis patients, revealing BDS as a predictive marker for recurrence and MACE, with significant implications for predicting MACE, while SUV was not related to MACE. Recurrence, defined by prednisolone-induced SUV variability, was observed in approximately 30% of CS patients.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Ling Xiao, Chijun Deng, Haoyue Zhu, Xiaomei Gao, Jian Li, Zhiquan Yang, Dingyang Liu, Li Feng, Shuo Hu
Summary: This study investigated the patterns of metabolic abnormalities using [F-18]FDG PET in MTLE patients with different pathologic types. It was found that MTLE patients with isolated gliosis had the worst prognosis and exhibited significant hypometabolism in the insula. Therefore, hypometabolic regions should be prioritized for presurgical evaluation of MTLE patients rather than focusing solely on metabolic uptake values.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Lu, Nadera J. Sweiss, Homer A. Macapinlac
Summary: According to recent publications, including large cohort retrospective studies and prospective clinical trials, we are discussing the optimal methods for myocardial suppression in FDG PET/CT evaluation of patients with suspected cardiac sarcoidosis.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sampath Santhosh, Godwin Jeeva, Raja Thirumalairaj
Summary: Sarcoidosis, a systemic disorder with unknown causes, can develop during chemotherapy but often resolves spontaneously without specific treatment. Understanding the anatomical-metabolic pattern of sarcoidosis can help prevent misinterpretation during restaging PET/CT after chemotherapy.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Sonya Youngju Park, Eun Kyoung Choi, Jin Kyoung Oh, Joo Hyun Oh, Ie Ryung Yoo, Yong An Chung
Summary: This study compared the survival of breast cancer patients with and without BAT activity on FDG PET/CT. The results showed that patients with BAT activity had longer progression-free survival, with a more significant difference observed in premenopausal women.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Hematology
Matthew Nayor, Priya Gajjar, Venkatesh L. Murthy, Patricia E. Miller, Raghava S. Velagaleti, Martin G. Larson, Ramachandran S. Vasan, Gregory D. Lewis, Gary F. Mitchell, Ravi V. Shah
Summary: By measuring the changes in blood pressure and vascular stiffness, the cardiac and vascular components of exercise blood pressure can be analyzed. The study found that higher peak exercise blood pressure is associated with both higher arterial stiffness and higher cardiac-peripheral performance, especially in women. Therefore, studying the response of blood pressure to exercise in relation to vascular and cardiac physiology can reveal mechanisms of hypertension and clarify the clinical interpretation of exercise blood pressure.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Khaled Shelbaya, Brian Claggett, Pranav Dorbala, Hicham Skali, Scott D. Solomon, Kunihiro Matsushita, Suma Konety, Thomas H. Mosley, Amil M. Shah
Summary: This study investigated the prevalence, progression, and association with incident cardiovascular diseases of valvular heart disease (VHD) stages according to the American College of Cardiology/American Heart Association guidelines. The results showed that subclinical VHD is common in older adults, with a significant proportion at risk and with progressive VHD. It is also independently associated with the risk of incident cardiovascular events.
Letter
Cardiac & Cardiovascular Systems
Brittany Weber, Zachary S. Wallace, Sean Parks, Claire Cook, Daniel M. Huck, Michael Garshick, Jenifer M. Brown, Sanjay Divakaran, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Katherine P. Liao, Ayaz Aghayev, Hyon K. Choi, Marcelo Di Carli
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ravi Shah, Lyn M. Steffen, Matthew Nayor, Jared P. Reis, David R. Jacobs Jr, Norrina B. Allen, Donald Lloyd-Jones, Katie Meyer, Joanne Cole, Paolo Piaggi, Ramachandran S. Vasan, Clary B. Clish, Venkatesh L. Murthy
Summary: Metabolite signatures of diet are associated with long-term CM-CVD independent of lifestyle and traditional risk factors. Metabolomics improves precision to identify adverse consequences and pathways of diet-related CM-CVD.
EUROPEAN HEART JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomoe Hagio, Jonathan B. Moody, Alexis Poitrasson-Riviere, Jennifer M. Renaud, Lora Pierce, Christopher Buckley, Edward P. Ficaro, Venkatesh L. Murthy
Summary: This study assessed the diagnostic performance of DLAC compared to NAC for detection of CAD, and the results showed that DLAC outperformed NAC in detecting obstructive CAD in patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Andrew S. Perry, Jeffrey S. Annis, Hiral Master, Matthew Nayor, Andrew Hughes, Aymone Kouame, Karthik Natarajan, Kayla Marginean, Venkatesh Murthy, Dan M. Roden, Paul A. Harris, Ravi Shah, Evan L. Brittain
Summary: This study used data from commercial wearable devices and electronic health records to investigate the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) in a real-world population. The results showed that increased time spent in any type of physical activity was associated with a lower risk of T2DM, regardless of age, sex, BMI, or sedentary time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Eric J. Brandt, Dariush Mozaffarian, Cindy W. Leung, Seth A. Berkowitz, Venkatesh L. Murthy
Summary: Poor nutrition is the main cause of poor health, high healthcare expenditure, and decreased productivity globally. Social determinants of health, such as food insecurity and nutrition insecurity, influence cardiometabolic diseases. This article focuses on distinguishing between food insecurity and nutrition insecurity, providing an overview of their concepts, measurement, prevalence, and links to health disparities. The discussions here contribute to future research and action to address the negative consequences of food and nutrition insecurity.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Hicham Skali, David Walker, Jeanette Jiang, Giridharan Gurumoorthy, Kalatu Davies, Tomomi Kimura
Summary: This study aimed to assess whether a prior COVID-19 infection was associated with a higher risk of complications during and following pharmacologic myocardial perfusion imaging stress testing. The results showed that although there was a slight association between COVID-19 history and reversal agent use, all-cause costs, and office visits, these differences were not clinically meaningful. Therefore, there is no need for special concern regarding the use of stress agents in patients with a history of COVID-19 infection.
CLINICAL CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Toral R. Y. Patel, Todd Villines, Christopher M. Kramer
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Chaitanya Madamanchi, Richard L. L. Weinberg, Venkatesh L. L. Murthy
Summary: This study aimed to determine the optimal timing and diagnostic thresholds of serum beta-hydroxybutyrate (BHB) levels in identifying incomplete suppression of myocardial glucose utilization (MGU). The results showed that BHB levels had a high sensitivity and specificity in suppressing MGU, which could simplify the interpretation of F-18-FDG PET/CT inflammation studies.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Dominik C. Benz, Christoph Grani, Panagiotis Antiochos, Bobak Heydari, Mark Colin Gissler, Yin Ge, Sarah A. M. Cuddy, Sharmila Dorbala, Raymond Y. Kwong
Summary: Cardiac magnetic resonance offers multiple facets in the diagnosis, risk stratification, and management of patients with myocardial diseases. Particularly, its feature to precisely monitor disease activity lends itself to quantify response to novel therapeutics.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Diego Ramonfaur, Hicham Skali, Brian Claggett, B. Gwen Windham, Priya Palta, Dalane Kitzman, Chiadi Ndumele, Suma Konety, Amil M. Shah
Summary: This study aimed to quantify the association between frailty and longitudinal changes in cardiac function, as well as the relationship between cardiac function and progression in frailty status. The study found that frailty status in older adults is associated with left atrial and diastolic dysfunction, and the progression of frailty status is related to changes in left ventricular structure and function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Christoph Grani, Marius R. Bigler, Raymond Y. Kwong
Summary: The purpose of this review is to evaluate how noninvasive comprehensive anatomic- and physiologic evaluation can guide patient management for anomalous aortic origin of a coronary artery (AAOCA). The review explores the role of noninvasive multimodality imaging in characterizing AAOCA, with a focus on the pathophysiology of myocardial ischemia and stress testing protocols.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Gastroenterology & Hepatology
Brian J. Pepe-Mooney, Colton J. Smith, Marc S. Sherman, Trista E. North, Robert F. Padera, Wolfram Goessling
Summary: This study provides comprehensive immunopathological evaluation of liver tissue from 33 severe cases of SARS-CoV-2 infection, revealing the absence of viral infection in hepatocytes and cholangiocytes. Viral RNA molecules are found in the hepatic sinusoids of some patients, indicating potential viral impact on liver function. The presence of viral aggregates in liver, colocalized with platelets and fibrin clots, suggests the formation of virus-containing sinusoidal microthrombi. Moreover, the downtrend of liver function tests over time in this patient cohort indicates unattenuated viral replication.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Tanayott R. Thaweethai, Sarah E. Jolley, Elizabeth Karlson, Emily M. Levitan, Bruce Levy, Grace McComsey, Lisa S. McCorkell, Girish D. Nadkarni, Sairam E. Parthasarathy, Upinder J. Singh, Tiffany Walker, Caitlin W. Selvaggi, Daniel Shinnick, Carolin C. M. P. Schulte, Rachel M. Atchley-Challenner, Leora Horwitz, Andrea Foulkes
Summary: This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) using self-reported symptoms and analyze the frequencies of PASC across different cohorts, vaccination status, and number of infections. The results show that PASC is associated with various symptoms and around 10% of participants were PASC positive at 6 months after infection.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)