Article
Cardiac & Cardiovascular Systems
Seung Hun Lee, Juwon Kim, Adrien Lefieux, David Molony, Doosup Shin, Doyeon Hwang, Ki Hong Choi, Ha-Sung Chang, Ki-Hyun Jeon, Hyun-Jong Lee, Ho-Jun Jang, Hyun Kuk Kim, Sang Jin Ha, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Joon-Hyung Doh, Eun-Seok Shin, Chang-Wook Nam, Bon-Kwon Koo, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: This study aimed to evaluate the clinical implications of residual FFR gradient after successful PCI, and found that objective analysis using dFFR(t)/dt improved classification agreement on the presence of the major residual FFR gradient among operators. Patients with a major residual FFR gradient had a higher risk of target vessel failure at 2 years.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Avedis Ekmejian, Hari Sritharan, Dinesh Selvakumar, Venkateshka Venkateshka, Usaid Allahwala, Michael Ward, Ravinay Bhindi
Summary: This meta-analysis investigated the outcomes of diabetic and non-diabetic patients in whom revascularization was deferred based on negative FFR. The study found that diabetes was associated with an increased risk of cardiovascular events, unplanned revascularization, all-cause mortality, and cardiovascular mortality compared to non-diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mattia Galli, Stefano Benenati, Andrea Zito, Davide Capodanno, Giuseppe Biondi Zoccai, Luis Ortega-Paz, Antonio Iaconelli, Domenico D'Amario, Italo Porto, Francesco Burzotta, Carlo Trani, Raffaele De Caterina, Mario Gaudino, Javier Escaned, Dominick J. Angiolillo, Filippo Crea
Summary: In patients with chronic coronary syndrome, physiology-guided PCI and CABG are associated with better outcomes compared to angiography-guided PCI. CABG also reduces the rates of myocardial infarction and death, but increases the risk of stroke.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fukang Hu, Daixin Ding, Jelmer Westra, Yingguang Li, Wei Yu, Zhiqing Wang, Takashi Kubo, Juan Luis Gutierrez-Chico, Yundai Chen, William Wijns, Shengxian Tu
Summary: This meta-analysis evaluated the diagnostic accuracy of Optical Flow Ratio (OFR) in assessing intermediate coronary stenosis. The results showed high diagnostic concordance between OFR and wire-based FFR, indicating the potential of OFR in accurately evaluating coronary artery disease.
Article
Cardiac & Cardiovascular Systems
Jelmer Westra, Ashkan Eftekhari, Shengxian Tu, Gianluca Campo, Javier Escaned, Simon Winther, Hitoshi Matsuo, Xinkai Qu, Lukasz Koltowski, Yunxiao Chang, Tommy Liu, Junqing Yang, Birgitte Krogsgaard Andersen BSc, William Wijns, Morten Bottcher, Evald Hoj Christiansen, Bo Xu, Niels Ramsing Holm
Summary: The study evaluated the diagnostic performance of quantitative flow ratio (QFR) compared to fractional flow reserve (FFR) and resting distal-to-aortic pressure ratio (resting Pd/Pa). QFR showed higher diagnostic accuracy when corresponding to FFR and resting Pd/Pa. Discordance between resting Pd/Pa and FFR was related to age, sex, hypertension, and lesion severity.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Medicine, General & Internal
Annette M. M. Maznyczka, Connor J. J. Matthews, Jonathan M. M. Blaxill, John P. P. Greenwood, Abdul M. M. Mozid, Jennifer A. A. Rossington, Murugapathy Veerasamy, Stephen B. B. Wheatcroft, Nick Curzen, Heerajnarain Bulluck
Summary: This study compared the efficacy and safety of FFR-guided versus angiography-guided management strategies in patients with obstructive CAD. The results showed no difference in outcomes such as all-cause mortality, MI, and unplanned revascularisation, but an FFR-guided strategy led to significantly fewer patients needing revascularisation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Gabor Tamas Szabo, Aron Uveges, Balazs Tar, Andras Agoston, Azzaya Dorj, Csaba Jenei, Rudolf Kolozsvari, Benjamin Csippa, Daniel Czuriga, Zsolt Koszegi
Summary: A new evaluation method based on flow measurement can better guide treatment decisions for atherosclerotic coronary heart disease, with the flow separation index (FSi) showing correlation with the degree of stenosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Mihir A. Kelshiker, Henry Seligman, James P. Howard, Haseeb Rahman, Michael Foley, Alexandra N. Nowbar, Christopher A. Rajkumar, Matthew J. Shun-Shin, Yousif Ahmad, Sayan Sen, Rasha Al-Lamee, Ricardo Petraco
Summary: This meta-analysis aims to quantify the association between reduced coronary flow and all-cause mortality and major adverse cardiovascular events (MACE). The results show that abnormal coronary flow reserve (CFR) is associated with higher incidence of all-cause mortality and MACE. Each 0.1 unit reduction in CFR is associated with a proportional increase in mortality and MACE.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick W. Serruys, Nozomi Kotoku, Jinying Zhou, Shigetaka Kageyama, Shinichiro Masuda, Pruthvi C. Revaiah, Bo Wang, Xingqiang He, Tsung-Ying Tsai, Momoko Kageyama, Emelyne Sevestre, Faisal Sharif, Scot Garg, Takashi Akasaka, Javier Escane, Manesh R. Patel, Yoshinobu Onuma
Summary: This study investigated the diagnostic accuracies of 5 angio-FFR software/methods and found that they had higher discrimination for predicting FFR<=0.8 compared to 2-dimensional QCA %DS, but did not reach the diagnostic accuracy previously reported in validation studies.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Gabor G. Toth, Carlos Collet, Anne Langhoff Thuesen, Takuya Mizukami, Filip Casselman, Lars Peter Riber, Frank Van Praet, Anders Junker, Sakura Nagumo, Bernard De Bruyne, Lisette Okkels Jensen, Emanuele Barbato
Summary: Surgical grafting of coronaries with functionally nonsignificant stenoses was associated with a higher risk of graft failure, and every 0.10 decrease in FFR units was correlated with a 56% reduction in the risk of graft failure.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Bruno, Fabrizio D'Ascenzo, Giorgio Marengo, Roberto Manfredi, Andrea Saglietto, Guglielmo Gallone, Luca Franchin, Francesco Piroli, Filippo Angelini, Ovidio De Filippo, Federico Conrotto, Pierluigi Omede, Antonio Montefusco, Mauro Pennone, Massimo Boffini, Marco Pocar, Mauro Rinaldi, Gaetano Maria De Ferrari
Summary: FFR-driven CABG can reduce the number of anastomoses and on-pump procedures without increasing the risk of MACE and without reducing graft occlusion at angiographic follow-up.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Bernard De Bruyne, Nico H. J. Pijls, Emanuele Gallinoro, Alessandro Candreva, Stephane Fournier, Danielle C. J. Keulards, Jeroen Sonck, Marcel Van't Veer, Emanuele Barbato, Jozef Bartunek, Marc Vanderheyden, Eric Wyffels, Annemiek De Vos, Mohamed El Farissi, Pim A. L. Tonino, Olivier Muller, Carlos Collet, William F. Fearon
Summary: This study proposes microvascular resistance reserve (MRR) as a specific index for assessing coronary microvascular function, independent of autoregulation and myocardial mass, based on absolute values of coronary flow and pressure. The research found a strong correlation between continuous thermodilution-derived MRR and Doppler MRR, suggesting MRR as a specific, quantitative, and operator-independent metric for quantifying coronary microvascular dysfunction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Valerie Stegehuis, Jelmer Westra, Coen Boerhout, Martin Sejr-Hansen, Ashkan Eftekhari, Hernan Mejia-Renteria, Maribel Cambero-Madera, Niels Van Royen, Hitoshi Matsuo, Masafumi Nakayama, Maria Siebes, Evald Hoj Christiansen, Tim van de Hoef, Jan Piek
Summary: The study explored the association between invasive coronary physiology parameters and 2D and 3D qualitative coronary angiography, finding that 2D-QCA analysis resulted in less severe stenosis severity. Some lesions showed an angiographic-functional mismatch, suggesting that coronary angiography may not always accurately identify lesions associated with myocardial ischemia.
Article
Cardiac & Cardiovascular Systems
Tim P. van de Hoef, Valerie E. Stegehuis, Maribel I. Madera-Cambero, Niels van Royen, Nina W. van der Hoeven, Guus A. de Waard, Martijn Meuwissen, Evald H. Christiansen, Ashkan Eftekhari, Giampaolo Niccoli, Tim Lockie, Hitoshi Matsuo, Masafumi Nakayama, Tsunekazu Kakuta, Nobuhiro Tanaka, Lorena Casadonte, Jos A. E. Spaan, Maria Siebes, Jan G. P. Tijssen, Javier Escaned, Jan J. Piek
Summary: This study highlights the importance of core laboratory analysis in evaluating lesion classification and clinical outcomes when performing combined coronary flow reserve (CFR) and fractional flow reserve (FFR) measurements. The agreement between FFR/CFR results is associated with a lower risk of major adverse cardiac events (MACE) and target vessel failure (TVF), raising doubts about the necessity of routine revascularization in vessels with low FFR but preserved CFR.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Melinda Boussoussou, Istvan F. Edes, Fanni Nowotta, Borbala Vattay, Milan Vecsey-Nagy, Zsofia Drobni, Judit Simon, Marton Kolossvary, Balazs N. Nemeth, Adam L. Jermendy, David Becker, Jonathon Leipsic, Campbell Rogers, Amy Collinsworth, Pal Maurovich-Horvat, Bela Merkely, Balint Szilveszter
Summary: This study aimed to evaluate the changes in invasive fractional flow reserve (FFRi) of non-infarction related lesions over time in ST-elevation myocardial infarction (STEMI) patients. The study found that coronary CT angiography-derived FFR (FFRCT) had a higher accuracy in predicting follow-up FFRi compared to baseline FFRi. This suggests that FFRCT could be a valuable tool in identifying hemodynamically relevant non-IRA lesions in STEMI patients.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Transplantation
Solene M. Laville, Aymeric Couturier, Oriane Lambert, Marie Metzger, Nicolas Mansencal, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Bruce M. Robinson, Benedicte Stengel, Sophie Liabeuf, Ziad A. Massy
Summary: This study aimed to determine the association between serum urea levels and adverse cardiovascular events and death in patients with chronic kidney disease (CKD) before renal replacement therapy (RRT). The study found that elevated serum urea levels were associated with increased risk of atheromatous and non-atheromatous cardiovascular events, as well as higher mortality rates.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Fabio R. Salerno, Alireza Akbari, Sandrine Lemoine, Timothy J. Scholl, Christopher W. McIntyre, Guido Filler
Summary: Pediatric CKD is associated with altered tissue sodium concentration compared to healthy controls, with increased sodium concentration in glomerular disease and reduced sodium concentration in tubular disorders.
PEDIATRIC NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Jakobsen, Evald H. Christiansen, Phillip Freeman, Johnny Kahlert, Karsten Veien, Michael Maeng, Bent Raungaard, Julia Ellert, Steen D. Kristensen, Martin K. Christensen, Christian J. Terkelsen, Troels Thim, Ashkan Eftekhari, Rebekka Jensen, Nicolaj B. Stottrup, Anders Junker, Henrik S. Hansen, Lisette O. Jensen
Summary: In both ACS and non-ACS patients, the DTS stent was associated with a higher risk of TLF at 12 months compared to the O-SES, mainly due to higher rates of TLR.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Transplantation
Maelys Granal, Denis Fouque, Micher Ducher, Jean-Pierre Fauvel
Summary: This study used artificial intelligence to define the relationship between kalemia, dietary potassium intake, and renal function in chronic kidney disease (CKD) patients. The results showed that strict dietary potassium control is not necessary to regulate kalemia in CKD1-4 patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Anfisa Puchkova-Sistac, Blandine de Lauzon-Guillain, Nicolas Girerd, Jean-Marc Boivin, Erwan Bozec, Ludovic Merckle, Julie-Anne Nazare, Martine Laville, Patrick Rossignol, Sandra Wagner
Summary: This study aimed to assess the associations between eating behavior and cardiovascular damage or metabolic syndrome after 13 years. The results showed that emotional eating was associated with an increased risk of diastolic dysfunction after 13 years. External eating was slightly associated with lower pulse-wave velocity. These findings suggest that cardiovascular prevention should take into account eating behavior and include teaching emotion regulation skills.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Oriol Rodriguez-Leor, Beatriz Toledano, Ramon Lopez-Palop, Fernando Rivero, Salvatore Brugaletta, Jose Antonio Linares, Tomas Benito, Pilar Carrillo, Marti Puigfel, German Cediel, Mario Sadaba, Beatriz Vaquerizo, Juan Rondan, Ivan Gomez, Fernando Alfonso, Roberto Saez, Ana Planas, Fernando Lozano, Felipe Hernandez, Manel Sabate, Jose Ramoen Ruiz-Arroyo, Francisco Torres, Jose Maria de la Torre Hernandez, Enrique Gutierrez, Ana Belen Cid-Alvarez, Jose Luis Diez, Luis Fernandez, Jose Moreu, Soledad Ojeda, Pablo Cerrato, Valeriano Ruiz-Quevedo, Juan Sanchis, Antonio Gomez-Menchero, Raymundo Ocaranza, Mohsen Mohandes, Jose Maria Hernandez, Miren Maite Alfageme, Pablo Aguiar, Jose Ramon Lopez Minguez, Armando Perez de Prado
Summary: Using intracoronary pressure wire in patients with intermediate coronary artery stenosis can lead to changes in diagnosis, treatment strategy, and clinical outcomes. This study highlights the importance of intracoronary pressure wire in guiding revascularization in coronary artery disease patients.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Clinical Neurology
Marlene Heinze, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Josep Puig, Robin Lemmens, Vincent Thijs, Keith W. Muir, Norbert Nighoghossian, Alina Koenigsberg, Marit Jensen, Ewgenia Barow, Iris Lettow, Salvador Pedraza, Claus Z. Z. Simonsen, Christian Gerloff, Gotz Thomalla
Summary: This study evaluated the impact of clinical and imaging baseline factors and treatment on early neurological improvement (ENI) in MRI-guided intravenous thrombolysis for unknown onset stroke. The results showed that early neurological improvement is an important indicator of treatment effect, and early administration of thrombolysis increases the likelihood of ENI.
CEREBROVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Waldmann, Francis Bessiere, Kevin Gardey, Mohamed Bakloul, Emre Belli, Damien Bonnet, Anne-Solene Chaussade, Sarah Cohen, Hubert Delasnerie, Nabil Dib, Sylvie Di Filippo, Arnaud Dulac, Sebastien Hascoet, Roland Henaine, Laurence Iserin, Clement Karsenty, Magalie Ladouceur, Antoine Legendre, Sophie Malekzadeh-Milani, Mansour Mostefa Kara, Jelena Radojevic, Miarisoa Ratsimandresy, Eloi Marijon, Alice Maltret, Paul Khairy, Nicolas Combes
Summary: This study aims to assess the role of EPS in predicting ventricular arrhythmias in patients with tetralogy of Fallot before pulmonary valve replacement. The results show that EPS can effectively predict the presence of ventricular tachycardia and guide treatment decisions.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julien Dreyfus, Yohann Bohbot, Augustin Coisne, Yoan Lavie-Badie, Michele Flagiello, Baptiste Bazire, Florian Eggenspieler, Florence Viau, Elisabeth Riant, Yannick Mbaki, Damien Eyharts, Thomas Senage, Thomas Modine, Martin Nicol, Fabien Doguet, Thierry Le Tourneau, Christophe Tribouilloy, Erwan Donal, Jacques Tomasi, Gilbert Habib, Christine Selton-Suty, Costin Radu, Pascal Lim, Richard Raffoul, Bernard Iung, Jean-Francois Obadia, Etienne Audureau, David Messika-Zeitoun
Summary: This study aimed to evaluate the predictive value of TRI- SCORE for in-hospital mortality in redo ITVS patients and compare its accuracy with conventional surgical risk scores. The study found that TRI- SCORE was the only surgical risk score associated with in-hospital mortality, with an AUC value of 0.83, much higher than logistic EuroSCORE and EuroSCORE II. Therefore, TRI- SCORE can guide the clinical decision-making process.
Review
Medicine, Research & Experimental
Elisa B. Monteiro, Matheus Ajackson, Milena B. Stockler-Pinto, Fitsum Guebre-Egziabher, Julio B. Daleprane, Christophe O. Soulage
Summary: This review analyzed the renoprotective effects of sulforaphane (SFN) in preclinical models of kidney diseases. The results showed that SFN improved renal function, reduced kidney injury, and decreased urinary protein excretion and kidney fibrosis. These findings suggest that SFN supplementation may be a potential therapeutic strategy for kidney disease.
Article
Multidisciplinary Sciences
Yves Gouriou, Fabrice Gonnot, Mariam Wehbi, Camille Brun, Ludovic Gomez, Gabriel Bidaux
Summary: Genetically encoded biosensors based on fluorescent proteins (FPs) are widely used to monitor calcium ion (Ca2+) dynamics and sub-cellular spatial distribution in cells. The mitochondrial-associated membranes (MAMs), which connect the endoplasmic reticulum (ER) and mitochondria, have recently gained attention due to their role in calcium homeostasis and mitochondrial function. However, the sensitivity of the existing Ca2+ biosensors on the outer-mitochondrial membrane (OMM) is not sufficient to measure sub-micromolar changes in Ca2+ concentration. In this study, a new highly sensitive Ca2+ biosensor was developed and demonstrated to detect smaller differences in Ca2+ levels in or near the MAMs. Notably, the study also revealed the endogenous activity of IP3-receptors in the Ca2+ leak channel on the OMM during hypoxia or when SERCA activity is blocked.
Article
Nutrition & Dietetics
Luc Gaussens, Emmanuel Gonzalez-Bautista, Marc Bonnefoy, Marguerite Briand, Neda Tavassoli, Philipe De Souto Barreto, Yves Rolland
Summary: This study described the vitality domain of intrinsic capacity (IC) in community-dwelling older people and examined the associations of appetite and weight loss with other IC domains. The results showed that appetite and weight loss are common among older adults and are related to impairments in psychological and locomotion abilities.
Article
Hematology
Oriane Marmontel, Yara Abou-Khalil, Olivier Bluteau, Bertrand Cariou, Valerie Carreau, Sybil Charriere, Eleonore Divry, Antonio Gallo, Philippe Moulin, Francois Paillard, Noel Peretti, Jean-Pierre Rabes, Mathilde Varret, Alain Carrie, Mathilde Di Filippo
Summary: This study investigated the phenotype of 21 adult patients who carried rare LDLR and APOE variants in a French cohort. The results showed that LDLR+APOE carriers had higher blood lipid levels and a higher incidence of premature atherosclerotic cardiovascular diseases compared to LDLR carriers alone.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Rozenn Quarck, Lynn Willems, Birger Tielemans, Leanda Stoian, Alicja Ronisz, Allard Wagenaar, Frederic Perros, Guido Claessen, Agnieszka Ciarka, Laurent Godinas, Catharina Belge, Marc Jacquemin, Marion Delcroix
Summary: The crucial role of angiogenesis in clot resolution and fibrothrombotic obstruction of the pulmonary arterial bed in CTEPH was validated using a rabbit model. Inhibiting intrathrombus angiogenesis resulted in elevated pulmonary arterial pressure, increased pulmonary vascular resistance, and right ventricular hypertrophy, accompanied by pulmonary vessel remodeling and inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Oestreicher, Agnese Vella, Olivier Muller, Matthias Kirsch, Eric Eeckhout, Stephane Fournier, Pierre Monney, Olivier Roux, Christan Roguelov, Philippe Zhang, Paul Abraham, Clemence Ferlay, Panagiotis Antiochos, Henri Lu
Summary: The prevalence of carotid artery stenosis (CAS) in patients undergoing transcatheter aortic valve implantation (TAVI) is not well-documented. This study aimed to investigate the impact of CAS, especially severe or bilateral CAS, on the prognosis after TAVI. The results showed that while CAS as a whole did not predict neurovascular complications, bilateral CAS was associated with an increased risk of stroke after TAVI.
JOURNAL OF INVASIVE CARDIOLOGY
(2023)