期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 64, 期 18, 页码 1950-1963出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2014.07.986
关键词
neurological events; stroke; surgical aortic valve replacement; transcatheter aortic valve replacement
资金
- Edwards Lifesciences
Neurological events after transcatheter (TAVR) or surgical aortic valve replacement (SAVR) are potentially devastating and associated with a poor prognosis. With technological improvements and increased operator experience, their incidence is markedly declining, justifying the need for surrogate endpoints to be used in future comparative trials. Moreover, imaging studies after TAVR and SAVR suggest that neurological events are mainly embolic in nature; however, there is significant discrepancy between imaging findings and clinically overt symptoms, raising the possibility of more subtle subclinical cognitive decline. Different modalities have been used to assess both overt and subclinical neurological events after SAVR and TAVR. The purpose of this report is to systematically review and describe currently used imaging, functional, and neurocognitive testing modalities and to better understand how they could be integrated in future prospective studies. (C) 2014 by the American College of Cardiology Foundation.
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