Article
Agriculture, Dairy & Animal Science
C. H. Gaukroger, S. A. Edwards, J. Walshaw, A. Nelson, I. P. Adams, C. J. Stewart, I Kyriazakis
Summary: Knowledge of the periparturient longitudinal changes in sow microbiota composition is crucial to understanding the sow's role in piglet microbiota development and improving her gut health during lactation. The study found that primiparous sows had lower microbiota diversity during the periparturient period, while multiparous sows showed an increase in relative abundance of certain bacterial genera.
Article
Hematology
Najla El Jurdi, Shernan G. Holtan, Andrea Hoeschen, Jessica Velguth, Benjamin Hillmann, Brian C. Betts, Margaret L. MacMillan, Daniel J. Weisdorf, Alexander Khoruts, Armin Rashidi, Robin Shields-Cutler
Summary: This study found a correlation between the gastrointestinal microbiome and chronic graft-versus-host disease (cGVHD) and revealed differences in microbiome composition and metabolic pathways between cGVHD patients and controls. The baseline microbiome of cGVHD patients showed significant differences, and the metabolic capacity also differed in these patients. These findings suggest the potential therapeutic use of microbiome manipulation for cGVHD prevention.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
William Johnston, Bob T. Rosier, Miguel Carda-Dieguez, Michael Paterson, Paddy Watson, Krystyna Piela, Marilyn Goulding, Gordon Ramage, Divyashri Baranyia, Tsute Chen, Nezar N. Al-Hebshi, Alex Mira, Shauna Culshaw
Summary: This study investigated the early and later changes in subgingival biofilm following periodontal treatment and found that hand and ultrasonic instruments had similar impacts on the composition of the subgingival plaque microbiome. There were marked changes in biofilm composition in the early stages after treatment, but limited evidence of these changes being associated with treatment outcomes.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Brianna N. Maslen, Lesley A. Gray, Seyed A. Ghorashi, Jason D. White, Michael A. Campbell, Sameer D. Pant
Summary: Microorganisms in the gut have a significant impact on the health and productivity of livestock. When cattle are placed in feedlots, there are observable changes in the gut microorganisms, including reduced diversity within individuals and increased differences between animals.
Article
Biochemistry & Molecular Biology
Elizabeth K. Mallott, Lotte H. Skovmand, Paul A. Garber, Katherine R. Amato
Summary: This study investigates the seasonal variation in the gut metabolome of black howler monkeys and its association with gut microbiome composition and nutrient intake. The results show that faecal metabolite profiles differ significantly between seasons, mainly due to changes in plant metabolite consumption. However, microbial community composition and faecal metabolite composition are not strongly associated. The study also reveals that the gut microbiome buffers seasonal variation in dietary intake, with limited buffering effect when host diet becomes calorically or nutritionally restricted.
Article
Immunology
Shuang Zhai, Yang Qu, Dan Zhang, Tingting Li, Yang Xie, Xiaoyan Wu, Liwei Zou, Yajuan Yang, Fangbiao Tao, Shuman Tao
Summary: This study found linear and nonlinear relationships between depressive symptoms and chronic inflammation levels among young adults. Additionally, symptom-specific depressive symptoms were associated with inflammation during a 2-year follow-up.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jeferson M. Lourenco, Taylor R. Krause, Christina B. Welch, Todd R. Callaway, T. Dean Pringle
Summary: This study investigated the longitudinal changes in the rumen microbiota of Angus beef steers from weaning to slaughter. The results showed that the ruminal microbial composition of the steers at a younger age was similar to that of the adult cows, but differentiated after weaning.
Article
Microbiology
Emily A. Kaelin, Cynthia Rodriguez, Carla Hall-Moore, Julie A. Hoffmann, Laura A. Linneman, I. Malick Ndao, Barbara B. Warner, Phillip Tarr, Lori R. Holtz, Efrem S. Lim
Summary: This study found that changes in the viral and bacterial composition of the gut precede the onset of necrotizing enterocolitis (NEC) in preterm infants. The results suggest that the early life virome signatures in preterm infants may play a role in NEC.
NATURE MICROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Jonathan K. L. Mak, Ralf Kuja-Halkola, Ge Bai, Linda B. Hassing, Nancy L. Pedersen, Sara Hagg, Juulia Jylhava, Chandra A. Reynolds
Summary: Using data from Swedish twin cohort studies, this research investigates the longitudinal trajectories of frailty in late life and the contributions of genes and environment. The study finds that the heterogeneity of frailty in late life is mainly attributable to environmental influences, highlighting the importance of targeting environmental risk factors to mitigate frailty in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Robert Valeris-Chacin, Bonnie Weber, Timothy J. Johnson, Maria Pieters, Randall S. Singer
Summary: This study investigated the association between Campylobacter and broiler litter microbiome in commercial broiler flocks over the production cycle. The results revealed differences in Campylobacter dynamics in the litter throughout the cycle and between small and big broilers. The study also identified bacterial genera negatively associated with Campylobacter abundance in litter, suggesting their potential as antagonists to Campylobacter colonization in the broiler environment.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Shasta McMillen, Sydney Thomas, Emily Liang, Eric B. Nonnecke, Carolyn Slupsky, Bo Lonnerdal
Summary: The gut microbiota is implicated in the adverse developmental outcomes of postnatal iron supplementation, and the form of iron can influence microbiota diversity and metabolite changes. Early iron provision can have long-term effects on the gut microbiota and microbial metabolism in adult rats.
Article
Gastroenterology & Hepatology
Eun Soo Kim, Leonid Tarassishin, Caroline Eisele, Amelie Barre, Nilendra Nair, Alexa Rendon, Kelly Hawkins, Anketse Debebe, Sierra White, Anne Thjomoe, Einar Mork, Mario Bento-Miranda, Hinaben Panchal, Manasi Agrawal, Anish Patel, Ching-Lynn Chen, Asher Kornbluth, James George, Peter Legnani, Elana Maser, Holly Loudon, Maria-Teresa Mella, Joanne Stone, Marla Dubinsky, Joao Sabino, Joana Torres, Jean-Frederic Colombel, Inga Peter, Jianzhong Hu
Summary: Pregnancy is associated with reduced inflammatory activity in mothers with IBD, however, babies born to mothers with IBD show subclinical inflammation in early life. The study findings suggest a correlation between maternal FC levels and bacterial abundance.
Article
Obstetrics & Gynecology
Katherine T. Li, Fan Li, Heather Jaspan, Dorothy Nyemba, Landon Myer, Grace Aldrovandi, Dvora Joseph-Davey
Summary: Pregnant women in sub-Saharan Africa have higher rates of maternal morbidity. The vaginal microbiome has an impact on maternal health, including HIV and STI acquisition. This study found that the vaginal microbiota of South African women shifted towards lactobacillus dominance during pregnancy and towards a diverse anaerobe-dominant profile in the postpartum period. The findings also showed associations between microbial composition and STI diagnosis.
REPRODUCTIVE SCIENCES
(2023)
Article
Food Science & Technology
Feitong Liu, Shiting He, Jingyu Yan, Shuyuan Yan, Juchun Chen, Zerong Lu, Bin Zhang, Jonathan Lane
Summary: The study found a significant association between the levels of HMOs in Chinese breastmilk and maternal characteristics, as well as the infant gut microbiome. As lactation went on, both the diversity of breastmilk and infant gut microbiome significantly increased. Additionally, the concentration of dominant HMOs in the milk of secretors showed a significant decrease over time.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Immunology
Supriya D. Mehta, Debarghya Nandi, Walter Agingu, Stefan J. Green, Fredrick O. Otieno, Dulal K. Bhaumik, Robert C. Bailey
Summary: This study investigated the composition of the penile microbiome in a heterosexual population over a 1-year period. The results showed that the penile microbiome composition was influenced by circumcision status, sexual practices, female partner's vaginal microbiome composition, bacterial vaginosis status, and HSV-2 infection. Understanding these factors could potentially lead to therapeutic interventions to reduce HSV-2 and bacterial vaginosis infections in men and their female sex partners.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sungho Do, Liz Koutsos, Pamela L. Utterback, Carl M. Parsons, Maria R. C. de Godoy, Kelly S. Swanson
JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Veterinary Sciences
Stephanie C. J. Keating, Adrianna M. Sage, Tamas D. Ambrisko, Amy Somrak, Meredith Q. Carroll, Patricia M. Oba, Bianca Martins, Kelly S. Swanson
VETERINARY ANAESTHESIA AND ANALGESIA
(2020)
Article
Chemistry, Multidisciplinary
Hongping Deng, Christian J. Konopka, Tzu-Wen L. Cross, Kelly S. Swanson, Lawrence W. Dobrucki, Andrew M. Smith
Article
Agriculture, Dairy & Animal Science
Gloria A. Casas, Laia Blavi, Tzu-Wen L. Cross, Anne H. Lee, Kelly S. Swanson, Hans H. Stein
JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Julia Guazzelli Pezzali, Heather L. Acuff, Will Henry, Celeste Alexander, Kelly S. Swanson, Charles G. Aldrich
JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Thunyaporn Phungviwatnikul, Helen Valentine, Maria R. C. de Godoy, Kelly S. Swanson
JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
David Allaway, Richard Haydock, Zoe N. Lonsdale, Oliver D. Deusch, Ciaran O'Flynn, Kevin R. Hughes
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Veterinary Sciences
S. Gomart, D. Allaway, M. Harrison, D. Dickson, J. Seo, L. Ferasin, J. R. Payne, M. J. Hezzell, K. Borgeat
JOURNAL OF SMALL ANIMAL PRACTICE
(2020)
Article
Orthopedics
Csaba Matta, Christopher R. Fellows, Helen Quasnichka, Adam Williams, Bernadette Jeremiasse, David Allaway, Ali Mobasheri
Summary: The study implicates the protein clusterin in the catabolic responses of chondrocytes, particularly highlighting the suppressed release of its secreted form after cytokine stimulation, potentially limiting its cytoprotective function. Analysis of equine cartilage explants and osteochondral biopsies confirmed elevated release of MMP-3, MMP-13, COMP, and sGAG following cytokine treatment, indicating cartilage degradation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marissa R. Pallotto, Patricia M. Oba, Maria R. C. de Godoy, Kirk L. Pappan, Preston R. Buff, Kelly S. Swanson
Summary: The study utilized metabolomic techniques to analyze the effects of reduced food intake and weight loss in overweight cats, identifying a continual shift in metabolite profile as weight loss progressed. Most lipid metabolites decreased, but ketone bodies and small lipid particles increased with weight loss, while carbohydrate metabolites decreased.
Article
Agriculture, Dairy & Animal Science
Jujhar Atwal, Jonathan Stockman, Matthew Gilham, David Allaway, Helen Renfrew, Anne Marie Bakke, Phillip Watson
Summary: The study examined the effects of a high calcium diet on adult beagles for 40 weeks and found no measurable adverse health effects. This suggests that the consequences of high calcium intake on adult dogs of different breeds and sizes warrant further investigation.
Article
Veterinary Sciences
Anne Marie Bakke, Joshua Wood, Carina Salt, David Allaway, Matt Gilham, Gail Kuhlman, Tiffany Bierer, Richard Butterwick, Ciaran O'Flynn
Summary: The study showed that feeding grain-free diets with high inclusion of split peas and lentils may lead to canine diet-induced dilated cardiomyopathy, and the data will help generate hypotheses for future studies.
BMC VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
David Allaway, Janet E. Alexander, Laura J. Carvell-Miller, Rhiannon M. Reynolds, Catherine L. Winder, Ralf J. M. Weber, Gavin R. Lloyd, Andrew D. Southam, Warwick B. Dunn
Summary: Biomarker discovery using biobank samples collected from veterinary clinics can provide insights into the diverse population of pets and accelerate diagnostic development. Metabolomics analysis of DBS samples is a valuable approach to detect health/disease phenotypes. The study demonstrates that DBS samples are suitable for biomarker discovery.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Geriatrics & Gerontology
Carina Salt, Emi K. Saito, Ciaran O'Flynn, David Allaway
Summary: Aging is a complex process involving changes in metabolic processes, immune capacities, and genetic/epigenetic repertoires. With exposure to environmental stresses and deterioration of physiological functions, body systems become more susceptible to chronic inflammation and various pathologies. This study used disease diagnosis data from millions of cats and dogs to define adult life stages based on age clusters and disease patterns, providing valuable information for healthcare recommendations.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Patrick C. Barko, Stanley I. Rubin, Kelly S. Swanson, Maureen A. McMichael, Marcella D. Ridgway, David A. Williams
Summary: Exocrine pancreatic insufficiency (EPI) is a digestive disorder in dogs caused by insufficient secretion of digestive enzymes. In this study, untargeted metabolomics analysis was used to identify metabolic disturbances associated with EPI. 114 serum metabolites were found to differ significantly between dogs with EPI and healthy controls, suggesting malnourishment, micronutrient deficiencies, altered gut microbiome composition, and intestinal inflammation in dogs with EPI.