Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Guojian Yang, Le Li, Xi Peng, Guodong Tang, Naixin Zheng, Ying Zhao, Hui Li, Huiping Zhang, Fucheng Sun, Hu Ai
Summary: This retrospective study evaluated the reproducibility and diagnostic performance of coronary angiography-derived fractional flow reserve (caFFR) in the diagnosis of coronary stenosis. The results showed that caFFR had good diagnostic accuracy and high correlation with invasive fractional flow reserve (FFR). Rating: 8/10.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, General & Internal
Valerie Stegehuis, Jelmer Westra, Coen Boerhout, Martin Sejr-Hansen, Ashkan Eftekhari, Hernan Mejia-Renteria, Maribel Cambero-Madera, Niels Van Royen, Hitoshi Matsuo, Masafumi Nakayama, Maria Siebes, Evald Hoj Christiansen, Tim van de Hoef, Jan Piek
Summary: The study explored the association between invasive coronary physiology parameters and 2D and 3D qualitative coronary angiography, finding that 2D-QCA analysis resulted in less severe stenosis severity. Some lesions showed an angiographic-functional mismatch, suggesting that coronary angiography may not always accurately identify lesions associated with myocardial ischemia.
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The study aimed to evaluate the feasibility and efficacy of a post-PCI FFR-guided optimization strategy compared to standard coronary angiography in achieving final post-PCI FFR values >= 0.90. While the FFR-guided optimization strategy did not significantly increase the proportion of patients with final FFR >= 0.90, it did significantly reduce the proportion of patients with final FFR <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xianpeng Wu, Bokai Wu, Wenming He, Xinhong Wang, Kan Wang, Zhengzheng Yan, Zaiheng Cheng, Yuyu Huang, Wei Zhang, Rongliang Chen, Jia Liu, Jian'an Wang, Xinyang Hu
Summary: By expanding the coronary tree in the computational fluid dynamics (CFD) domain, the accuracy of coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) (FFRCT) was significantly improved, leading to a 16.7% increase in sensitivity and the conversion of false-negative cases into true-positive cases. Additionally, the NKS method was able to solve the computational problem efficiently, achieving favorable computational times for future clinical applications.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tara Neleman, Alessandra Scoccia, Kaneshka Masdjedi, Mariusz Tomaniak, Jurgen M. R. Ligthart, Karen T. Witberg, Alise Vermaire, Quinten Wolff, Leon Visser, Paul Cummins, Isabella Kardys, Jeroen Wilschut, Roberto Diletti, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen
Summary: Lower post-PCI vFFR values are significantly associated with an increased risk of TVF and TVR at 5 years follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Fay M. A. Nous, Tobias Geisler, Mariusz B. P. Kruk, Hatem Alkadhi, Kakuya Kitagawa, Rozemarijn Vliegenthart, Michaela M. Hell, Jorg Hausleiter, Patricia K. Nguyen, Ricardo P. J. Budde, Konstantin Nikolaou, Cezary Kepka, Robert Manka, Hajime Sakuma, Sachin B. Malik, Adriaan Coenen, Felix Zijlstra, Ernst Klotz, Pim van der Harst, Christoph Artzner, Admir Dedic, Francesca Pugliese, Fabian Bamberg, Koen Nieman
Summary: In this multicenter study, the combination of dynamic stress CT myocardial perfusion imaging (CT-MPI) with coronary CT angiography (CTA) showed incremental diagnostic value for the identification of hemodynamically significant coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Srdjan B. Aleksandric, Ana D. Djordjevic-Dikic, Milan R. Dobric, Vojislav L. Giga, Ivan A. Soldatovic, Vladan Vukcevic, Miloje Tomasevic, Sinisa M. Stojkovic, Dejan N. Orlic, Jovica D. Saponjski, Milorad B. Tesic, Marko D. Banovic, Marija T. Petrovic, Stefan A. Juricic, Milan A. Nedeljkovic, Goran Stankovic, Miodrag C. Ostojic, Branko D. Beleslin
Summary: The study found that the use of diastolic-FFR during dobutamine provocation is more reliable for assessing myocardial bridging compared to conventional FFR, providing better functional significance of MB in relation to stress-induced myocardial ischemia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-hai Zhao, Wei-feng Guo, Zhi-feng Yao, Shan Yang, Hong Yun, Yin-yin Chen, Tong-tong Han, Xiao-yue Zhou, Cai-xia Fu, Meng-su Zeng, Chen-guang Li, Cui-zhen Pan, Hang Jin
Summary: In this study, a fully automated pixel-wise post-processing framework was used to evaluate quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). The study aimed to assess the additional value of coronary magnetic resonance angiography (CMRA) in the diagnostic performance of fully automated pixel-wise quantitative CMR-MPI for detecting hemodynamically significant coronary artery disease (CAD). The results showed that the fully automated pixel-wise quantitative CMR-MPI can accurately detect hemodynamically significant CAD, but the integration of CMRA did not provide significantly additive value.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cian P. Mccarthy, Sean P. Murphy, Daniel K. Amponsah, Paula K. Rambarat, Claire Lin, Yuxi Liu, Reza Mohebi, Allison Levin, Avanthi Raghavan, Hannah Miksenas, Campbell Rogers, Jason H. Wasfy, Ron Blankstein, Brian Ghoshhajra, Sandeep Hedgire, James L. Januzzi
Summary: This study aimed to evaluate the presence and characteristics of coronary artery disease (CAD) among patients with type 2 myocardial infarction (T2MI). Coronary computed tomography angiography (CTA), fractional flow reserve derived with coronary CTA (FFRCT), and plaque volume analyses were conducted on consecutive eligible individuals with T2MI according to the Fourth Universal Definition of Myocardial Infarction criteria.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Na Zhao, Yang Gao, Bo Xu, Weixian Yang, Lei Song, Tao Jiang, Li Xu, Hongjie Hu, Lin Li, Wenqiang Chen, Dumin Li, Feng Zhang, Lijuan Fan, Bin Lu
Summary: The study aimed to investigate the impact of coronary calcification severity on the performance of CT-derived FFR. Results showed that CT-FFR had high sensitivity, specificity, accuracy, and AUC values in both per-patient and per-vessel analysis, with no significant difference in diagnostic performance among different CAC score groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masahiro Hoshino, Seokhun Yang, Tomoyo Sugiyama, Jinlong Zhang, Yoshihisa Kanaji, Rikuta Hamaya, Masao Yamaguchi, Masahiro Hada, Tomoki Horie, Kai Nogami, Hiroki Ueno, Toru Misawa, Taishi Yonetsu, Doyeon Hwang, Joo Myung Lee, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Bon-Kwon Koo, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study found that the prevalence of coronary microvascular dysfunction (CMD) in patients with intermediate epicardial stenosis is about one-third. CMD was significantly associated with greater lumen volume, fibrofatty and necrotic component volume, and epicardial fat volume.
EUROPEAN RADIOLOGY
(2021)
Article
Mechanics
K. E. Hoque, M. Ferdows, S. Sawall, E. E. Tzirtzilakis, M. A. Xenos
Summary: Computed tomography coronary angiography image-based noninvasive virtual fractional flow reserve (vFFR) is a key factor in diagnosing coronary plaque, with both 1D and 3D hemodynamic factors being used to determine the severity of coronary main arteries lesions. The study shows that the 1D computational results can be used to predict the severity of atherosclerotic plaque in clinical procedures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Gassenmaier, Ilias Tsiflikas, Simon Greulich, Jens Kuebler, Florian Hagen, Konstantin Nikolaou, Andreas M. Niess, Christof Burgstahler, Patrick Krumm
Summary: This study evaluated computed tomography fractional flow reserve (FFRCT) values in distal coronary segments of marathon runners, finding a significant occurrence of false-positive values. This phenomenon was commonly observed in participants without anatomical coronary artery stenosis, partially attributable to small distal vessel diameters.
EUROPEAN RADIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Article
Cardiac & Cardiovascular Systems
Daniel T. Johnson, Johan Svanerud, Jung -Min Ahn, Hiram G. Bezerra, Damien Collison, Marcel van 't Veer, Barry Hennigan, Bernard De Bruyne, Richard L. Kirkeeide, K. Lance Gould, Nils P. Johnson
Summary: This study aimed to improve the phasic calibration of a fluid-filled catheter by considering its oscillatory behavior. The results showed that phasic matching against a high-fidelity pressure wire can be improved by automatically accounting for the oscillations of the fluid-filled catheter compared to standard equalization methods. Most tracings contain artifacts due to underdamped oscillations, and neglecting them leads to biased estimates of equalization parameters.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ole Froebert, Matthias Goetberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Joerg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: Influenza vaccination early after myocardial infarction (MI) improves prognosis, and its effectiveness may vary depending on the type of MI. The beneficial effect of influenza vaccination on adverse cardiovascular events may be enhanced in patients with non-ST-segment elevation MI (NSTEMI) compared to those with ST-segment elevation MI (STEMI).
AMERICAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jaclyn Carberry, Daniel Ang, Colin Berry
Article
Cardiac & Cardiovascular Systems
Martha Gulati, Najah Khan, Maria George, Colin Berry, Alaide Chieffo, Paolo G. Camici, Filippo Crea, Juan-Carlos Kaski, Mario Marzilli, C. Noel Bairey Merz
Summary: This study investigated the impact of INOCA (Ischemia with No Obstructive Coronary Arteries) on the quality of life of patients and found that INOCA symptoms were associated with adverse physical, social, and mental health. The study calls for increased patient awareness, physician recognition and diagnosis, and clinical trials to develop evidence-based guidelines for this increasingly recognized cardiovascular disorder.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mark A. Hlatky, Sam Wilding, Beth Stuart, Zoe Nicholas, James Shambrook, Zina Eminton, Kim Fox, Derek Connolly, Peter O'Kane, Alex Hobson, Anoop Chauhan, Neal Uren, Gerry P. Mccann, Colin Berry, Justin Carter, Carl Roobottom, Mamas Mamas, Ronak Rajani, Ian Ford, Pamela S. Douglas, Nick Curzen
Summary: The study compares costs between CTCA with selective FFRCT and standard care pathways in the FORECAST trial, and finds no significant difference in US healthcare costs. However, certain factors such as coronary risk factors and planned invasive angiography increase costs.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Medicine, General & Internal
Mehrdad A. Mizani, Ashkan Dashtban, Laura Pasea, Alvina G. Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B. Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry Hemingway, Cathie Sudlow, Amitava Banerjee, C. V. D. C. O. V. I. D. U. K. Consortium CVD COVID UK Consortium
Summary: A simple model using national, pre- and post-pandemic electronic health records has been developed to predict excess deaths in the early stages of a pandemic. Despite limited use in emergency preparedness, electronic health records can provide information for pandemic planning and surveillance.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
L. Polimac, M. M. C. J. van Leunen, G. J. van Steenbergen, J. M. Zelis, R. Eerdekens, M. van 't Veer, D. N. Schulz, I. F. Wijnbergen, P. J. Vlaar, K. Teeuwen
Summary: This study examined the impact of implementing a dedicated chronic total occlusion (CTO) team in a Dutch heart centre. The results showed that the success rate of CTO-PCI procedures increased after the implementation of the CTO team, especially for difficult and very difficult CTO lesions. The clinical outcomes and quality of life of patients also improved at the 1-year follow-up.
NETHERLANDS HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
F. E. Vervaat, A. van Der Gaag, C. Smetsers, P. C. Barneveld, M. Van't Veer, K. Teeuwen, H. van Suijlekom, L. Dekker, I. F. Wijnbergen
Summary: This study aims to investigate the efficacy of high density spinal cord stimulation in patients with refractory angina pectoris. The primary outcome is the reduction in myocardial ischemia measured by myocardial perfusion positron emission tomography scan. The study uses a randomized crossover design with a 1-year follow-up period.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jasper Vermeer, Tineke Vinck, Bianca de Louw, Stacey Slingerland, Marcel van't Veer, Marta Regis, Jos-marien Jansen, Edwin van den Heuvel, Lukas Dekker
Summary: Modifiable risk factors have a strong impact on the progression of atrial fibrillation (AF) and outcomes of ablation therapy. The POP trial aims to evaluate the effects of a dedicated nurse-led AF lifestyle outpatient clinic on clinical outcomes in patients with symptomatic AF. This randomized controlled trial will assess the efficacy and cost-effectiveness of an integrated technology-supported lifestyle therapy in AF patients. The trial is funded by the Netherlands Organisation for Health Research and Development and uses home sleep apnea testing devices provided by Itamar Medical, Ltd.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Annemiek de Vos, Tijn P. J. Jansen, Marcel van 't Veer, Aukelien Dimitriu-Leen, Regina E. Konst, Suzette Elias-Smale, Valeria Paradies, Laura Rodwell, Stijn van den Oord, Pieter Smits, Niels van Royen, Nico Pijls, Peter Damman
Summary: Microvascular resistance reserve (MRR), measured invasively using continuous thermodilution, is a new index for assessing coronary microvascular (dys)function. This study aimed to establish normal values for MRR and determine the optimal cutoff point. In patients with angina and no obstructive coronary artery disease, MRR was found to be a suitable index for distinguishing the presence or absence of coronary microvascular dysfunction (CMD).
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Colin Berry, John D. Mcclure, Keith G. Oldroyd
EUROPEAN HEART JOURNAL
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Rik J. C. van Esch, Iris C. Cramer, Xian Li, Cindy Verstappen, Carla Kloeze, Marcel van 't Veer, Angelique Dierick, Susan Hommerson, Leon Montenij, Lukas Dekker, R. Arthur Bouwman, Erik Korsten, Jan Bergmans, Sander Stuijk, Svitlana Zinger
Summary: Remote PPG enables contactless monitoring of cardiac rhythm using an RGB camera in a regular hospital environment. Three machine learning models were developed to detect atrial fibrillation (AF), classify if a cardiac arrhythmia (AF or Aflutter) is present, and classify the data into AF, Aflutter, and sinus rhythm. While the performance of detecting arrhythmia is close to the second model, distinguishing between AF and Aflutter remains a challenge.
MEDICAL IMAGING 2023
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Shuhao Que, Rik J. C. van Esch, Iris C. Cramer, Cindy Verstappen, Carla Kloeze, Marcel van 't Veer, Angelique Dierick, Susan Hommerson, Fokke van Meulen, Sebastiaan Overeem, Leon Montenij, Lukas Dekker, R. Arthur Bouwman, Erik Korsten, Jan Bergmans, Svitlana Zinger, Sander Stuijk
Summary: In this study, we investigated the feasibility of extracting continuous respiratory parameters using a single RGB camera in a short-stay ward. We implemented two algorithms, chest optical flow (COF) and energy variance maximization (EVM), to extract respiration from the patient's thoracic and facial areas, respectively. The results showed that COF and EVM achieved errors within 3 breaths per minute and 3.5 breaths per minute, respectively, for average breath-to-breath rate estimation. Furthermore, using respiratory features extracted from COF measurements, we achieved an average AUC value of 0.64 for detecting atrial fibrillation (AF) in the respiratory signal. This highlights the potential of using camera-based respiratory parameters as predictors for AF or as surrogate predictors when facial area extraction is not possible.
MEDICAL IMAGING 2023
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
D. Munhoz, C. Collet, D. Collison, T. Mizukami, P. McCartney, J. Sonck, T. Ford, C. Berry, B. De Bruyne, K. Oldroyd
EUROPEAN HEART JOURNAL
(2022)