Article
Radiology, Nuclear Medicine & Medical Imaging
Borek Foldyna, Thomas Mayrhofer, Michael T. Lu, Julia Karady, Marton Kolossvary, Maros Ferencik, Svati H. Shah, Neha J. Pagidipati, Pamela S. Douglas, Udo Hoffmann
Summary: The prognostic value of CT-derived coronary artery disease (CAD) characteristics differs across categories of clinical cardiovascular risk. Among patients with low cardiovascular disease risk, CAD >= 50% has the highest prognostic value, while coronary artery calcium (CAC) and high-risk plaque (HRP) have higher prognostic value among patients with high cardiovascular disease risk.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Rheumatology
Manphool Singhal, Rakesh Kumar Pilania, Ankur Kumar Jindal, Aman Gupta, Avinash Sharma, Sandesh Guleria, Nameirakpam Johnson, Muniraju Maralakunte, Pandiarajan Vignesh, Deepti Suri, Manavjit Singh Sandhu, Surjit Singh
Summary: Objective evaluation of coronary artery abnormalities (CAAs) in patients with Kawasaki disease (KD) is important. This study investigates the role of CT coronary angiography (CTCA) in detecting CAAs in the distal segments of coronary arteries in KD patients. The results show that CTCA can identify CAAs in the distal segments, including branches, of the coronary arteries, which cannot be detected by transthoracic echocardiography (TTE).
Article
Medicine, General & Internal
Robin Fabian Gohmann, Patrick Seitz, Konrad Pawelka, Nicolas Majunke, Adrian Schug, Linda Heiser, Katharina Renatus, Steffen Desch, Philipp Lauten, David Holzhey, Thilo Noack, Johannes Wilde, Philipp Kiefer, Christian Krieghoff, Christian Luecke, Sebastian Ebel, Sebastian Gottschling, Michael A. Borger, Holger Thiele, Christoph Panknin, Mohamed Abdel-Wahab, Matthias Horn, Matthias Gutberlet
Summary: ML-based CT-FFR can be used to correctly categorize cCTA studies without obstructive CAD, especially for less experienced readers. Image quality and coronary artery calcium score have no correlation with recategorization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liu Yang, Peng Peng Xu, U. Joseph Schoepf, Christian Tesche, Balakrishnan Pillai, Rock H. Savage, Chun Xiang Tang, Fan Zhou, Hao Dong Wei, Zhong Qiang Luo, Qing Gen Wang, Chang Sheng Zhou, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang
Summary: Fractional flow reserve and plaque progression assessed by serial coronary CT angiography predicted the risk of future major adverse cardiovascular events (MACE), demonstrating better accuracy compared to traditional assessment markers.
EUROPEAN RADIOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Zhaoping Wang, Hongji Yin, Wei Jing, Hui Sun, Ming Ru, Suhua Zhang, Yingcui Wang
Summary: This paper proposes the application research of FFR based on deep learning in the diagnosis of coronary heart disease complicated with diabetes mellitus. Through the core theoretical research on coronary heart disease complicated with diabetes mellitus and FFR, it is analyzed that the existing coronary angiography is still in the development stage and combined with FFR can play a better therapeutic effect.
NEURAL COMPUTING & APPLICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rui Guo, Jiao Deng, Pengfei Rong, Wanhui Zhou, Guozhi Zhang, Song Peng, Qi Liang, Xiao Yang, Pengzhi Hu
Summary: The study aimed to investigate the diagnostic value of one-stop combined CTA as the initial examination for suspected CAD or CCAD patients, and compare its clinical performance with two consecutive CTA scans. The results showed that one-stop combined CTA enabled effective detection of lesions in non-targeted regions, with reduced scan time and contrast medium dosage compared to two separate examinations. Therefore, it can be considered as a preferred first-line examination for patients suspected of CAD or CCAD.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fay M. A. Nous, Tobias Geisler, Mariusz B. P. Kruk, Hatem Alkadhi, Kakuya Kitagawa, Rozemarijn Vliegenthart, Michaela M. Hell, Jorg Hausleiter, Patricia K. Nguyen, Ricardo P. J. Budde, Konstantin Nikolaou, Cezary Kepka, Robert Manka, Hajime Sakuma, Sachin B. Malik, Adriaan Coenen, Felix Zijlstra, Ernst Klotz, Pim van der Harst, Christoph Artzner, Admir Dedic, Francesca Pugliese, Fabian Bamberg, Koen Nieman
Summary: In this multicenter study, the combination of dynamic stress CT myocardial perfusion imaging (CT-MPI) with coronary CT angiography (CTA) showed incremental diagnostic value for the identification of hemodynamically significant coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meiling Li, Runjianya Ling, Lihua Yu, Wenyi Yang, Zirong Chen, Dijia Wu, Jiayin Zhang
Summary: In this study, a deep learning model was developed for automated reconstruction of chronic total occlusion (CTO) imaging. The model significantly reduced postprocessing time and demonstrated excellent correlation and agreement in the assessment of occlusion features.
Article
Radiology, Nuclear Medicine & Medical Imaging
Natasa Javorszky, Balint Homonnay, Gary Gerstenblith, David Bluemke, Peter Kiss, Mihaly Torok, David Celentano, Hong Lai, Shenghan Lai, Marton Kolossvary
Summary: This study developed an open-source deep learning model for segmenting coronary plaques on coronary CT angiography. The model showed excellent performance in quantifying plaque volumes in both the test set and an external dataset, and transfer learning further improved the accuracy of the model.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Tanya Mohammadi, Babak Mohammadi
Summary: The aim of this study was to identify the most informative predictors of cardiovascular events in patients undergoing Coronary CT Angiography. The severity of stenosis in the left main coronary artery was found to be the most significant predictor of high-risk patients. CT Angiography showed higher performance in identifying high-risk patients compared to other methods.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroki Yamaura, Kenichiro Otsuka, Hirotoshi Ishikawa, Kuniyuki Shirasawa, Daiju Fukuda, Noriaki Kasayuki
Summary: This study investigates the relationship between EAT volume and coronary plaque burden and finds that LAP burden plays an important role in patient prognosis. CCTA can help improve personalized cardiac risk management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benedikt H. Heidinger, Dominique DaBreo, Rachae Kirkbride, Mario Santos, Brett J. Carroll, Stephanie A. Feldman, Donya Mohebali, Ian McCormick, Jason D. Matos, Warren J. Manning, Diana E. Litmanovich
Summary: This study evaluated the relationship between CAC on non-ECG-gated CTPA and short-term mortality in patients with acute PE. The results showed that CAC is common and associated with mortality in these patients. Visual assessment of CAC may be an easy tool for early risk stratification.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Caroline A. Berge, Ingeborg Eskerud, Elise B. Almeland, Terje H. Larsen, Eva R. Pedersen, Svein Rotevatn, Mai Tone Lonnebakken
Summary: This study aimed to investigate the association between hypertension and extensive non-obstructive coronary artery disease (CAD) in patients with symptomatic chronic coronary syndrome (CCS). The results showed that hypertension was associated with extensive non-obstructive CAD in CCS patients, independent of factors such as sex, age, smoking, diabetes, statin treatment, obesity, and calcium score.
Article
Cardiac & Cardiovascular Systems
William F. Griffin, Andrew D. Choi, Joanna S. Riess, Hugo Marques, Hyuk-Jae Chang, Jung Hyun Choi, Joon-Hyung Doh, Ae-Young Her, Bon-Kwon Koo, Chang-Wook Nam, Hyung-Bok Park, Sang-Hoon Shin, Jason Cole, Alessia Gimelli, Muhammad Akram Khan, Bin Lu, Yang Gao, Faisal Nabi, Ryo Nakazato, U. Joseph Schoepf, Roel S. Driessen, Michiel J. Bom, Randall Thompson, James J. Jang, Michael Ridner, Chris Rowan, Erick Avelar, Philippe Genereux, Paul Knaapen, Guus A. de Waard, Gianluca Pontone, Daniele Andreini, James P. Earls
Summary: This study compared the performance of artificial intelligence-enabled quantitative coronary computed tomography (AI-QCT) angiography analyses to conventional imaging and invasive tests for the detection and grading of coronary stenoses. The results demonstrated that AI-QCT analysis enables rapid and accurate identification and exclusion of high-grade stenosis, with a close agreement to quantitative coronary angiography.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Kosuke Inoue, Teresa E. Seeman, Tamara Horwich, Matthew J. Budoff, Karol E. Watson
Summary: Coronary artery calcium (CAC) is an important predictor of cardiovascular disease (CVD), but the impact of positive CAC on CVD varies among individuals. A study found that nearly 70% of low-risk individuals showed a significant increase in CVD risk when CAC>0, highlighting the need for CAC screening in these individuals.
Editorial Material
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Kang He Zheng, Parveen K. Garg, Weihua Guan, Seamus P. Whelton, Matthew J. Budoff, Michael Y. Tsai
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Infectious Diseases
Lydia N. Drumright, Robin M. Nance, Stephanie A. Ruderman, Jimmy Ma, Bridget M. Whitney, Andrew Hahn, Rob J. Fredericksen, Brandon Luu, William B. Lober, Richard D. Moore, Matthew J. Budoff, Jeanne C. Keruly, Katerina Christopoulos, Sarah Puryear, Amanda Willig, Karen Cropsey, William C. Mathews, Edward Cachay, Laura Bamford, Joseph J. Eron, Sonia Napravnik, Kenneth H. Mayer, Conall O'Cleirigh, Mary E. Mccaul, Geetanjali Chander, Matthew J. Feinstein, Michael S. Saag, Mari M. Kitahata, Susan R. Heckbert, Heidi M. Crane, Joseph A. C. Delaney
Summary: People with HIV have a higher risk of myocardial infarction, with a greater proportion of type 2 MI due to oxygen demand-supply mismatch compared with type 1 resulting from atherothrombotic plaque disruption. HIV-positive individuals report a higher prevalence of cigarette and alcohol use. However, the impact of smoking and alcohol consumption on MI type among people living with HIV is not well studied.
Article
Cardiac & Cardiovascular Systems
Marianna Mochen, Stefano Branzoli, Giovanni D'Onghia, Riccardo Pertile, Giulia Casagranda, Federica Spagnolli, Umberto Rozzanigo, Fabrizio Guarracini, Massimiliano Marini, Angelo Graffigna, Roberto Bonmassari, Katiuscia Menni, Giancarlo Mansueto, Filippo Cademartiri, Maurizio Centonze
Summary: This study aimed to assess the characteristics of left atrial appendage (LAA) stump and left atrial (LA) volume in patients with nonvalvular atrial fibrillation (NVAF) and contraindications to oral anticoagulation (OAC) after standalone thoracoscopic LAA exclusion. The results showed that all patients achieved successful closure of LAA, and the presence of LAA stump was observed in some patients. Both CCT and TOE were effective in identifying LAA characteristics and postprocedural residual stump.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riccardo Cau, Giuseppe Muscogiuri, Francesco Pisu, Marco Gatti, Birgitta Velthuis, Christian Loewe, Filippo Cademartiri, Gianluca Pontone, Roberta Montisci, Marco Guglielmo, Sandro Sironi, Antonio Esposito, Marco Francone, Nicholas Dacher, Charles Peebles, Gorka Bastarrika, Rodrigo Salgado, Luca Saba
Summary: The goal of this study is to develop a comprehensive clinical and imaging score, including TTE and CMR data, in a large cohort of TTC patients for risk stratification and outcome prediction as a basis for possible changes in patient management.
JOURNAL OF THORACIC IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hyung-Bok Park, Reza Arsanjani, Ji Min Sung, Ran Heo, Byoung Kwon Lee, Fay Y. Lin, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Jonathon A. Leipsic, Sang-Eun Lee, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Hyuk-Jae Chang
Summary: This study aimed to investigate the impact of statins on plaque progression in high-risk coronary atherosclerotic plaque (HRP) features and to identify predictive factors for rapid plaque progression in mild coronary artery disease (CAD) using serial coronary computed tomography angiography (CCTA). The results showed that statin therapy reduced plaque progression, particularly in lesions with a higher number of HRP features. The key factors for rapid plaque progression were =2 HRPs, current smoking, and diabetes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, A. Maxim Bax, Fay Y. Lin, Stephan Achenbach, Daniele Andreini, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin J. DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Gilbert L. Raff, Ronen Rubinshtein, Todd C. Villines, Hyuk-Jae Chang, Daniel S. Berman, James K. Min, Jeroen J. Bax, Leslee J. Shaw, Alexander R. van Rosendael
Summary: This study found that women develop coronary atherosclerosis approximately 12 years later than men, and post-menopausal women in the highest atherosclerotic burden group have a significantly higher risk for major adverse cardiovascular events (MACE) compared to men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Medicine, General & Internal
Xuan Jin, Eun-Ju Kang, Cai-De Jin, Kwang-Min Lee, Kyung-Hee Lim, Seung-Woon Rha, Cheol-Ung Choi, Hwan-Seok Yong, Sung-Cheol Yun, Matthew J. Budoff, Long-Hao Yu, Moo-Hyun Kim
Summary: This study found that dual-acquisition CCTA can support the non-invasive detection of vasospastic angina with relatively good specificity and positive predictive value (PPV).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Filippo Cademartiri, Antonella Meloni, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: The photon-counting detector (PCD) is a new technology that provides significant benefits for cardiac and coronary artery imaging. Compared with conventional CT, PCCT has improved capabilities such as multi-energy capability, increased spatial resolution, reduced radiation exposure, and optimized use of contrast agents. It also overcomes limitations of traditional CCT/CCTA, such as reducing artifacts and enabling more precise assessment of stenosis and plaque characteristics. PCCT also has potential applications in characterizing myocardial tissue using a double-contrast agent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Matthew J. Budoff, Khurram Nasir, Michael J. Blaha
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hae Seung Lee, Sang Hun Han, Ronald Swerdloff, Youngju Pak, Matthew Budoff, Christina Wang
Summary: This study found that testosterone treatment does not improve NAFLD in older hypogonadal men compared to placebo treatment. Further research is needed to confirm the effects of testosterone treatment on NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Antonella Meloni, Michela Parravano, Laura Pistoia, Alberto Cossu, Emanuele Grassedonio, Stefania Renne, Priscilla Fina, Anna Spasiano, Alessandra Salvo, Sergio Bagnato, Calogera Gerardi, Zelia Borsellino, Filippo Cademartiri, Vincenzo Positano
Summary: An unsupervised clustering method integrating demographic, clinical, and cardiac magnetic resonance (CMR) data was used to identify distinct phenogroups of beta-thalassemia intermedia patients. Three mutually exclusive phenogroups were identified based on unsupervised hierarchical clustering. PG2 exhibited a significantly higher risk of future cardiovascular events than PG1 and PG3. Clustering emerged as a useful tool for risk stratification in beta-thalassemia intermedia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Antonella Meloni, Vincenzo Positano, Laura Pistoia, Riccardo Righi, Massimiliano Missere, Emanuele Grassedonio, Nicolo Schicchi, Antonino Vallone, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Anna Spasiano, Filippo Cademartiri
Summary: This study explored the association between left ventricular global function index (LVGFI) and myocardial iron overload (MIO), left ventricular ejection fraction (LVEF), myocardial fibrosis, and heart failure (HF) in patients with beta-thalassemia major (TM). The results showed that LVGFI and LVEF were significantly lower in patients with significant MIO, and LVGFI was a stronger predictor of HF compared to LVEF. LVGFI has incremental diagnostic value for HF detection in TM patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonella Meloni, Aldo Carnevale, Paolo Gaio, Vincenzo Positano, Cristina Passantino, Alessia Pepe, Andrea Barison, Giancarlo Todiere, Chrysanthos Grigoratos, Giovanni Novani, Laura Pistoia, Melchiore Giganti, Filippo Cademartiri, Alberto Cossu
Summary: We established normal ranges for native T1 and T2 values in the human liver, which showed variation across hepatic segments and were independent of age and sex. These normal ranges are important for the diagnosis and progression of liver diseases.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)