Article
Chemistry, Medicinal
Fernando Pagels, Cintia Almeida, Vitor Vasconcelos, A. Catarina Guedes
Summary: This study evaluated the potential of marine cyanobacterium extracts as natural and sustainable ingredients in cosmetics. The extracts showed no cytotoxicity and demonstrated anti-hyaluronidase and anti-collagenase capacities, making them promising natural anti-aging ingredients. However, stability was lower at higher temperatures.
Article
Plant Sciences
Hiroki Takahashi, Arihiro Iwasaki, Naoaki Kurisawa, Ryota Suzuki, Ghulam Jeelani, Teruhiko Matsubara, Toshinori Sato, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: Motobamide, a novel cyclic peptide containing a C-prenylated cyclotryptophan residue, was isolated from a marine cyanobacterium. It showed moderate inhibition of Trypanosoma brucei rhodesiense growth, but exhibited weaker cytotoxicity against normal human cells.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Environmental Sciences
Abdul Mannan Zafar, Muhammad Asad Javed, Ashraf Aly Hassan, Endalkachew Sahle-Demessie, Stephen Harmon
Summary: This study investigated the biodesalination potential of P. keutzingianum at different levels of salinity and confirmed its ability to produce biomass, biosorb, bioaccumulate, and biomineralize in all tested salinities.
Article
Biochemistry & Molecular Biology
Nurul Farhana Salleh, Jiale Wang, Binu Kundukad, Emmanuel T. Oluwabusola, Delia Xin Yin Goh, Ma Yadanar Phyo, Jasmine Jie Lin Tong, Staffan Kjelleberg, Lik Tong Tan
Summary: Marine cyanobacteria produce bioactive specialized metabolites during blooms to defend against competing microbes and herbivores. Two compounds, benderadiene and lyngbyoic acid, were discovered from a marine cyanobacterium and found to inhibit gene expression in a dose-dependent manner. Lyngbyoic acid also displayed anti-biofilm activity. The discovery of these compounds provides insights into their ecological significance and potential as starting materials for analogs.
Article
Plant Sciences
Aki Yamano, Yuka Asato, Noriyuki Natsume, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Summary: Odookeanynes A and B, two acetylene-containing lipopeptides, were isolated from a marine cyanobacterium collected in Okinawa, Japan. Their structures were elucidated through spectroscopic analysis and Marfey's analysis. These compounds dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Arihiro Iwasaki, Kazuya Teranuma, Naoaki Kurisawa, Yulia Rahmawati, Ghulam Jeelani, Tomoyoshi Nozaki, William H. Gerwick, Kiyotake Suenaga
Summary: The antitrypanosomal linear peptide Iheyamide A (1) isolated from marine cyanobacterium was found to have the C-terminal pyrrolinone moiety as the key pharmacophore for its activity, with longer peptide chains showing stronger antitrypanosomal effects. The newly identified iheyanone (2) displayed weaker antitrypanosomal activity compared to Iheyamide A (1), providing insights for the design of antitrypanosomal drugs.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Dipesh Dhakal, Sofia Kokkaliari, Garret M. Rubin, Valerie J. Paul, Yousong Ding, Hendrik Luesch
Summary: In this study, a biosynthetic gene cluster (BGC) for Lyngbyastatins (Lbns) was identified and characterized in a marine cyanobacterium. The BGC was found to encode enzymes responsible for the production of compounds 1 and 2, which have anti-cancer activity. Similar BGCs were also identified in the genomes of other marine cyanobacteria.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Kairi Umeda, Arihiro Iwasaki, Raimu Taguchi, Naoaki Kurisawa, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: This study isolated four new macrolide glycosides from a marine cyanobacterium and determined their structures through spectroscopic analyses. These macrolides demonstrated moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense and showed no cytotoxicity against normal human cells at a certain concentration.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Alevtina Mikhaylina, Amira Z. Ksibe, Rachael C. Wilkinson, Darbi Smith, Eleanor Marks, James P. C. Coverdale, Vilmos Fulop, David J. Scanlan, Claudia A. Blindauer
Summary: Marine cyanobacteria utilize a unique zinc-sensor protein Zur to thrive at different zinc concentrations, contributing to their wide distribution in the global oceans.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Organic
Raimu Taguchi, Arihiro Iwasaki, Akira Ebihara, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: The translation: A 68 mu g amount of an acyclic polyketide named beru'amide was isolated from a marine cyanobacterium Okeania sp. Several cutting-edge techniques were applied to determine the structure and perform the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide demonstrated strong antitrypanosomal activity.
Article
Plant Sciences
Nan-Nan Niu, Lu Lu, Pan-Pan Peng, Zhi-Juan Fu, Dan Miao, Ming Zhou, Dror Noy, Kai-Hong Zhao
Summary: Biochemical analysis showed that the core structures of phycobilisomes (PBSs) in cyanobacteria and red-algae are similar, with identical L-CM topologies; deleting the top cylinder linker domain in L-CM splits the PBS core into two basal cylinders; removal of the helical-loop-helical domain at the N-terminal end of Arm2 disrupts basal cylinder assembly, while deletion of C-terminal amino acids has minimal effects.
Article
Chemistry, Organic
Geum Jin Kim, Samantha J. Mascuch, Emily Mevers, Paul D. Boudreau, William H. Gerwick, Hyukjae Choi
Summary: Luquilloamides A-G were isolated from a marine cyanobacterium found growing on eelgrass near Luquillo, Puerto Rico. The structures of these compounds were elucidated through detailed NMR and MS analyses, and they exhibited different structural features and antitumor activity.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
J. Mohammed Hussain, P. Muruganantham, Khaleel Ahamed Abdul Kareem
Summary: Biochemical markers against hydrogen peroxide-induced oxidative stress were developed in marine cyanobacteria under standard laboratory conditions. Two species of marine cyanobacteria, Synechococcus aeruginosus and Phormidium valderianum, showed the highest growth of certain enzymes, including Superoxide dismutase, catalase, peroxidase, and Glutathione S-transferase, which were identified as biochemical markers of oxidative stress against H2O2 in marine cyanobacteria. New isoforms of these enzymes were found in Synechococcus aeruginosus and Phormidium valderianum, and Synechococcus aeruginosus was suggested as the indicator species for biochemical markers against hydrogen peroxide in marine cyanobacteria. Peroxidase was suggested as a biochemical enzyme marker.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Organic
Akira Ebihara, Arihiro Iwasaki, Youhei Miura, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: The new polyhalogenated aryl sulfates, Bromoiesol sulfates A and B, were isolated from a marine cyanobacterium and their structures were elucidated using Small Molecule Accurate Recognition Technology and X-ray diffraction analysis. Total synthesis of Bromoiesol A sulfate and Bromoiesol A was achieved, and their inhibitory effects on Trypanosoma brucei rhodesiense were confirmed.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Green & Sustainable Science & Technology
Probir Das, Shoyeb Khan, Mohammed AbdulQuadir, Mahmoud Ibrahim Thaher, Alaa H. Hawari, Noora Alshamri, Ghamza AlGhasal, Hareb M. J. Al-Jabri
Summary: The removal of carbohydrates as a pretreatment from microalgal biomass improves the net energy recovery by increasing the yield of biocrude and alkane formation. The pretreated biomass has lower levels of total organic carbon and total nitrogen, and recycling aqueous phase liquid as a nutrient source affects the biomass yield and pigment content in Chroococcidiopsis sp.
Article
Biochemistry & Molecular Biology
Stuti N. Patel, Ravi R. Sonani, Gagan D. Gupta, Niraj Kumar Singh, Vinay Kumar, Datta Madamwar
Summary: Phycoerythrin (PE) from marine cyanobacteria Halomicronema sp. R31DM was purified and structurally characterized using X-ray crystallography, revealing a hexamer structure of hetero-dimers with chromophores attached to peptide chains. The study enriches the understanding of cyanobacterial PE structure and its potential light-harvesting capacity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
Prachi Singh, Kunal R. Jain, Jayendra Lakhmapurkar, Deepa Gavali, Chirayu Desai, Datta Madamwar
Summary: The eco-restoration of mine-tailing sites has significant effects on native microbial communities and soil physicochemical properties. A study on the microbial changes during the early stages of phytoremediation in lignite minetailing soils revealed the primary microbial succession initiated by revegetation, which improved the soil quality.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Biochemistry & Molecular Biology
Hiral Mistry, Gagan Deep Gupta
Summary: Transcription-coupled repair (TCR) is a pathway for the repair of DNA lesions that block transcription. UV-stimulated scaffold protein A (UVSSA) is a cofactor involved in the stabilization of the TCR complex and recruitment of DNA-repair machinery. Human UVSSA interacts with DNA and RNA and has at least two nucleic acid binding regions, the N-terminal domain and C-terminal tail region. This study provides insights into the functional characteristics of UVSSA proteins.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biotechnology & Applied Microbiology
Stuti N. N. Patel, Ravi R. R. Sonani, Mukesh G. G. Chaubey, Gagan D. D. Gupta, Niraj Kumar Singh, Vinay Kumar, Datta Madamwar
Summary: In this study, the hexameric assembly structure of phycocyanin from Synechococcus Sp. R42DM was characterized by X-ray crystallography to understand its light-harvesting and antioxidant properties. The analysis revealed the chromophore microenvironment and possible light energy transfer mechanism in phycocyanin. The structural attributes responsible for its antioxidant potential were also identified and annotated.
Article
Biology
Ravi R. Sonani, Nathaniel C. Esteves, Abigail A. Horton, Rebecca J. Kelly, Amanda L. Sebastian, Fengbin Wang, Mark A. B. Kreutzberger, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman
Summary: Significant gaps remain in our understanding of how bacteriophages assemble and function. This study provides cryo-EM structures of the Agrobacterium phage Milan, revealing insights into the poorly understood neck region and its connection to the tail. The study also highlights the presence of proteins and disulfide bond networks that contribute to the structural stability of Milan.
COMMUNICATIONS BIOLOGY
(2023)
Article
Environmental Sciences
Shruti Sharma, Shabnam Shaikh, Sarayu Mohana, Chirayu Desai, Datta Madamwar
Summary: Petroleum and its derivatives are major environmental pollutants worldwide. The review explores emerging bioremediation technologies and evaluates their effectiveness and limitations in treating petroleum hydrocarbon polluted sites.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Manohar Lal Das, Vishwesh Jatala, Gagan Raj Gupta
Summary: Researchers propose a joint partitioning and sampling algorithm for addressing the challenges of distributed graph neural networks, which effectively reduces communication costs and improves accuracy.
2022 IEEE 29TH INTERNATIONAL CONFERENCE ON HIGH PERFORMANCE COMPUTING, DATA, AND ANALYTICS, HIPC
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Aalam Sohal, Hunza Chaudhry, Kanwal Bains, Armaan Dhaliwal, Gagan Gupta, Piyush Singla, Raghav Sharma, Dino Dukovic, Marina Roytman
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Aalam Sohal, Hunza Chaudhry, Armaan Dhaliwal, Raghav Sharma, Piyush Singla, Sohail Sodhi, Gagan Gupta, Dino Dukovic, Kris Kowdley
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Aalam Sohal, Hunza Chaudhry, Armaan Dhaliwal, Piyush Singla, Raghav Sharma, Sohail Sodhi, Gagan Gupta, Dino Dukovic, Devang Prajapati
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Aalam Sohal, Hunza Chaudhry, Armaan Dhaliwal, Sohail Sodhi, Gagan Gupta, Piyush Singla, Raghav Sharma, Dino Dukovic, Kris Kowdley
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Aalam Sohal, Hunza Chaudhry, Arpine Petrosyan, Armaan Dhaliwal, Gagan Gupta, Sohail Sodhi, Piyush Singla, Raghav Sharma, Dino Dukovic, Jayakrishna Chintanaboina
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)