Article
Nutrition & Dietetics
Wagner Jorge Ribeiro Domingues, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato, Nelson Wolosker, Antonio Eduardo Zerati, Pedro Puech-Leao, Daniel Boari Coelho, Pollyana Mayara Nunhes, Andre Alberto Moliterno, Ademar Avelar
Summary: The study found that short- and long-term creatine supplementation did not significantly affect functional capacity and calf muscle oxygen saturation parameters in patients with symptomatic peripheral arterial disease.
Review
Cardiac & Cardiovascular Systems
Adam A. Behroozian, Joshua A. Beckman
Summary: Peripheral Artery Disease (PAD) is a manifestation of atherosclerosis that can lead to reduced perfusion of the limb and metabolic dysregulation. The classification of asymptomatic PAD is relatively new, and there is a lack of clinical research on therapies for this population, presenting an opportunity for further exploration. Widespread screening for asymptomatic PAD could potentially reduce morbidity and mortality associated with PAD.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Health Care Sciences & Services
Shelley Alexander, Chris Seenan
Summary: This study evaluated the content of websites regarding the treatment and management of PAD and IC. The results showed that these websites were generally accurate but had low credibility, comprehensiveness, and readability.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew W. Gardner, Polly S. Montgomery, Ming Wang, Menglu Liang
Summary: This randomized controlled trial compared the long-term effects of different exercise programs on symptomatic participants with peripheral artery disease. The study found that a long-term home exercise program (HEP) and transitioning from short-term supervised exercise therapy (SET) to HEP (SET/HEP) were both effective in improving peak walking time and exercise time-to-minimum calf muscle oxygen saturation. These improvements were also correlated with each other.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Joshua A. Beckman, Peter A. Schneider, Michael S. Conte
Summary: Effective revascularization in peripheral artery disease goes beyond just the procedure, requiring understanding of the urgency of revascularization based on the patient's presentation. Recent developments in tools and options such as open surgical bypass have improved outcomes in lower extremity revascularization, even though evidence to guide practice is limited.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Zeljko Reiner, Johan De Sutter, Lars Ryden, Erkin Mirrakhimov, Nana Pogosova, Marina Dolzhenko, Zlatko Fras, Kornelia Kotseva, David Wood, Dirk De Bacquer
Summary: This study investigated the prevalence of PAD and suspected PAD in CHD patients, finding that PAD patients had worse risk factor profiles and lower health-related quality of life.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Surgery
Holger Lawall, Peter Bramlage, Michaela Gorath, Thomas Wittig
Summary: The study showed sustained clinical efficacy and adequate safety of sublingual nitroglycerin powder in patients with peripheral artery disease. Significant increases in ICD and ACD were observed after treatment, and this effect lasted until week 26. Further studies are needed to confirm the findings of this phase IIa proof of concept study.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Peripheral Vascular Disease
Amy E. Harwood, Christopher J. A. Pugh, Charles J. Steward, Campbell Menzies, C. Doug Thake, Tom Cullen
Summary: Heat therapy shows potential to improve walking distance and ankle-brachial pressure indices in patients with IC, with whole-body immersion demonstrating superior results compared to other interventions. However, no significant improvements were observed in quality of life or brachial blood pressure. More research is needed to establish appropriate heat therapy protocols and understand its effectiveness through randomised controlled trials.
Review
Nutrition & Dietetics
Ahmed Ismaeel, K. Leigh Greathouse, Nathan Newton, Dimitrios Miserlis, Evlampia Papoutsi, Robert S. Smith, Jack L. Eidson, David L. Dawson, Craig W. Milner, Robert J. Widmer, William T. Bohannon, Panagiotis Koutakis
Summary: PAD affects over 200 million people worldwide, resulting in significant functional decline, with limited treatment options. Phytochemicals may have therapeutic effects on functional outcomes in PAD patients.
Article
Cardiac & Cardiovascular Systems
Poghni A. Peri-Okonny, Sarthak Patel, John A. Spertus, Elizabeth A. Jackson, Ali O. Malik, Jeremy Provance, Carlos Mena-Hurtado, Mehdi H. Shishehbor, Vittal Hijjaji, Kensey L. Gosch, Kim G. Smolderen
Summary: The study found no association between invasive treatment and physical activity levels in patients with claudication, despite the greater improvement in health status in the invasive treatment group. Increased physical activity was associated with better health status gains, suggesting that improving physical activity levels could potentially improve outcomes in peripheral artery disease (PAD).
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Barbara Sernek, Rok Kamnikar, Miran Sebestjen, Anja Boc, Vinko Boc
Summary: This study investigated the association between the number of CD34(+) hematopoietic cells in the peripheral blood of patients with peripheral artery disease (PAD) and their functional and atherogenic factors. The results showed that the number of CD34(+) cells was associated with the claudication distance and differed between patients with and without type II diabetes and active smokers, past smokers, and non-smokers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
S. Elissa Altin, Helen Parise, Connie N. Hess, Ning A. Rosenthal, Mark A. Creager, Herbert D. Aronow, Jeptha P. Curtis
Summary: This study evaluated the rates of revascularization and amputation after lower extremity femoropopliteal peripheral vascular intervention (PVI) in patients with intermittent claudication (IC). The 4-year amputation rate following FP PVI was 4.3%, with a major amputation rate of 3.2%. Further investigation is needed to identify risk factors for amputation.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Physics, Multidisciplinary
Farahnaz Fallahtafti, Zahra Salamifar, Mahdi Hassan, Hafizur Rahman, Iraklis Pipinos, Sara A. Myers
Summary: Supervised exercise therapy (SET) is a conservative non-operative treatment strategy for improving walking performance in patients with peripheral artery disease (PAD). The study found that after SET treatment, walking regularity decreased, ankle joint nonlinear variability increased, while linear measures did not change except for the knee joint.
Article
Surgery
Madeline D. Cetlin, Tamar Polonsky, Karen Ho, Dongxue Zhang, Lu Tian, Lihui Zhao, Philip Greenland, Diane Treat-Jacobson, Melina R. Kibbe, Michael H. Criqui, Jack M. Guralnik, Mary M. McDermott
Summary: This study identified barriers to participation in supervised exercise therapy covered by CMS for lower extremity PAD. The majority of participants had never been prescribed or recommended supervised exercise therapy by their physicians, and most were unwilling or unable to pay the required copay for CMS-covered sessions. Many individuals also cited travel to medical centers as a significant obstacle to participation. These findings highlight the significant barriers faced by PAD patients in accessing and participating in supervised exercise therapy.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Voci, Ugo Fedeli, Luca Valerio, Elena Schievano, Marc Righini, Nils Kucher, David Spirk, Stefano Barco
Summary: Based on data analysis of the Veneto region in Italy, PAD is a prevalent cardiovascular disease with significant impact on the population, and there are notable gender differences.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Surgery
Madeline D. Cetlin, Tamar Polonsky, Karen Ho, Dongxue Zhang, Lu Tian, Lihui Zhao, Philip Greenland, Diane Treat-Jacobson, Melina R. Kibbe, Michael H. Criqui, Jack M. Guralnik, Mary M. McDermott
Summary: This study identified barriers to participation in supervised exercise therapy covered by CMS for lower extremity PAD. The majority of participants had never been prescribed or recommended supervised exercise therapy by their physicians, and most were unwilling or unable to pay the required copay for CMS-covered sessions. Many individuals also cited travel to medical centers as a significant obstacle to participation. These findings highlight the significant barriers faced by PAD patients in accessing and participating in supervised exercise therapy.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Clinical Neurology
Marian Shahid, Ashley Rawls, Veronica Ramirez, Sephira Ryman, Veronica E. Santini, Laurice Yang, Sharon J. Sha, Jacob N. Hall, Thomas J. Montine, Amy Lin, Lu Tian, Victor W. Henderson, Brenna Cholerton, Maya Yutsis, Kathleen L. Poston
Summary: This study aimed to investigate pareidolias in patients across the Lewy body disease spectrum. Illusory responses were studied in 300 participants, and it was found that cognitively impaired LB patients were more likely to endorse illusory responses compared to other groups. The Noise Pareidolia Task can be used to screen for unobtrusive pareidolias in LB patients before the onset of hallucinations and delusions.
ANNALS OF NEUROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Xuan Wang, Brian Lee Claggett, Lu Tian, Marcus Vinicius Bolivar Malachias, Marc A. Pfeffer, Lee-Jen Wei
Summary: For personalized or stratified medicine, it is crucial to establish a reliable and efficient prediction model for a clinical outcome of interest. However, commonly used metrics like C statistics do not accurately assess the model's prediction accuracy. This article highlights the importance of finding a clinically interpretable measure that quantifies prediction accuracy for improved model selection and evaluation.
Article
Mathematics
Feng Hong, Lu Tian, Viswanath Devanarayan
Summary: High-dimensional data applications require the use of statistical and machine-learning algorithms to identify optimal biomarker signatures based on patient characteristics for predicting clinical outcomes in biomedical research. Regularization, particularly L-1-based regularization, is commonly used to improve prediction performance and feature selection. However, choosing the penalty parameter for regularization can be unstable and may lead to inflated predictive performance estimates. This paper proposes a Monte Carlo approach for robust regularization parameter selection and an additional cross-validation wrapper for objectively evaluating the final model's predictive performance.
Letter
Medicine, General & Internal
Ananya Das, Timothy A. Lin, Christine Lin, Tomer Meirson, Zachary R. McCaw, Lu Tian, Ethan B. Ludmir
Article
Oncology
Linfeng Chen, Qiming Tang, Keying Zhang, Qianyang Huang, Yun Ding, Bo Jin, Szumam Liu, Kuoyuan Hwa, C. James Chou, Yani Zhang, Sheeno Thyparambil, Weili Liao, Zhi Han, Richard Mortensen, James Schilling, Zhen Li, Robert Heaton, Lu Tian, Harvey J. Cohen, Karl G. Sylvester, Rebecca C. Arent, Xinyang Zhao, Doff B. Mcelhinney, Yumei Wu, Wenpei Bai, Xuefeng B. Ling
Summary: This study explores the potential use of metabolic changes as biomarkers for assessing ovarian cancer. The research identifies key gene expression pathways and proposes symmetric dimethylarginine (SDMA) and arginine as potential liquid biopsy biomarkers for ovarian cancer assessment.
Editorial Material
Urology & Nephrology
Vivek Charu, Lu Tian, Manjula Kurella Tamura, Maria E. Montez-Rath
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Ruben P. A. van Eijk, Leonard H. H. van den Berg, Kit C. B. Roes, Lu Tian, Tze L. L. Lai, Lorene M. M. Nelson, Chenyu Li, Anna Scowcroft, Jesus Garcia-Segovia, Ying Lu
Summary: Hybrid designs with both randomized arms and an external control cohort are proposed to enhance clinical trials by using concurrent registries. The methodology was evaluated in a randomized, placebo-controlled clinical trial for amyotrophic lateral sclerosis. Matching eligible external controls from a different calendar period led to bias in the treatment effect estimate. Hybrid trial designs utilizing a concurrent registry with rigorous matching can minimize bias and accelerate the development of new treatments.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Developmental Biology
Agnieszka Kalinowski, Lu Tian, Reenal Pattni, Hanna Ollila, Maroof Khan, Cindy Manko, Melissa Silverman, Meiqian Ma, Laurie Columbo, Bahare Farhadian, Susan Swedo, Tanya Murphy, Mats Johnson, Elisabeth Fernell, Christopher Gillberg, Margo Thienemann, Elizabeth D. Mellins, Douglas F. Levinson, Alexander E. Urban, Jennifer Frankovich
Summary: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a sudden-onset neuropsychiatric disorder with an increased prevalence of co-morbid autoimmune illness, particularly arthritis. PANS patients with low C4B copy number are at higher risk for subsequent Juvenile Idiopathic Arthritis (JIA) diagnosis. There is a possible association between low C4B and PANS age of onset, suggesting a potential role of C4B in different types of arthritis.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Immunology
Hector Bonilla, Lu Tian, Vincent C. Marconi, Robert Shafer, Grace A. Mccomsey, Mitchel Miglis, Philip Yang, Andres Bonilla, Lauren Eggert, Linda N. Geng
Summary: The global prevalence of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) is approximately 43%, while in the United States, around 11% of individuals who have been infected with SARSCoV-2 experience long COVID. The underlying causes of PASC are still under investigation, and there are currently no FDA-approved therapies. Naltrexone, a medication with anti-inflammatory and immunomodulatory properties, has shown potential as a therapeutic intervention for PASC, but further rigorous clinical trials are needed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Letter
Oncology
Zachary R. Mccaw, Lu Tian, Lee-Jen Wei
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Neela D. Thangada, Dongxue Zhang, Lu Tian, Lihui Zhao, W. Jack Rejeski, Karen J. Ho, Luigi Ferrucci, Bonnie Spring, Melina R. Kibbe, Tamar S. Polonsky, Michael H. Criqui, Mary M. Mcdermott
Summary: In this meta-analysis of individual participant data, home-based walking exercise was found to improve 6-minute walk more than supervised treadmill exercise in people with PAD. These findings support home-based walking exercise as a first-line therapy for walking limitations in PAD.
Article
Clinical Neurology
Xiaotong Jiang, Gabrielle Simoneau, Mel Zuercher, Yanic Heer, Philip van Hoevell, Adrian Harrington, Wanda Castro-Borrero, Carl de Moor, Fabio Pellegrini, Lu Tian, Arnfin Bergmann, Stefan Braune
Summary: This retrospective study assessed the overall and patient-specific effects of dimethyl fumarate (DMF) versus teriflunomide (TERI) in patients with relapsing-remitting multiple sclerosis (MS). The study utilized a precision medicine scoring approach and found that DMF had superior effectiveness in reducing relapse-related endpoints compared to TERI. Furthermore, the study identified a subgroup of patients for whom DMF was more effective than TERI.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Xuan Wang, Brian Lee Claggett, Lu Tian
Meeting Abstract
Peripheral Vascular Disease
Mary O. Whipple, Lihui Zhao, Lu Tian, Dongxue Zhang, Mary M. McDermott