High-Density Lipoprotein Particle Number A Better Measure to Quantify High-Density Lipoprotein?

Limitations in our ability to predict cardiovascular risk have fueled efforts to identify novel risk markers and to refine the measurement of traditional risk factors, such as low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Standard assays to evaluate LDL-C and HDL-C quantify the cholesterol content within the respective lipoprotein fraction. However, both LDL and HDL particles vary in their content of cholesterol, and thus determining the concentration of lipoprotein