Article
Medicine, General & Internal
Annejet Heida, Mathijs S. van Schie, Willemijn F. B. van der Does, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Natasja M. S. de Groot
Summary: This case-control study compared atrial conduction velocity (CV) in patients with and without atrial fibrillation (AF). The study found no significant difference in biatrial CV between the two groups, except for a reduction in CV in the Bachmann's bundle (BB) area in the AF group. AF was associated with prolonged total activation times and decreased voltages at BB, indicating a potential role of BB in AF development and maintenance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Roya Kamali, Eugene Kwan, Misha Regouski, T. Jared Bunch, Derek J. J. Dosdall, Ed Hsu, Rob S. S. Macleod, Irina Polejaeva, Ravi Ranjan
Summary: This study investigates the correlation between fiber direction derived from Diffusion Tensor Imaging (DTI) and atrial fibrillation (AF) inducibility, suggesting that fiber direction may contribute to the initiation and sustaining of AF.
Article
Physiology
Martin Eichenlaub, Bjoern Mueller-Edenborn, Jan Minners, Nikolaus Jander, Martin Allgeier, Heiko Lehrmann, Simon Schoechlin, Juergen Allgeier, Dietmar Trenk, Franz-Josef Neumann, Thomas Arentz, Amir Jadidi
Summary: Left atrial hypertension, electrical conduction slowing, and mechanical dysfunction are associated with ACM. These findings may be useful for risk stratification and development of therapeutic strategies for AF.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Annejet Heida, Willemijn F. B. van der Does, Mathijs S. van Schie, Lianne N. van Staveren, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Natasja M. S. de Groot
Summary: This study compared conduction heterogeneity between the supervulnerable period after electrical cardioversion and long-term sinus rhythm in patients with atrial fibrillation (AF). The findings suggest that there might be no difference in biatrial conduction characteristics between these two periods.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Cardiac & Cardiovascular Systems
Naoya Kurata, Masaharu Masuda, Takashi Kanda, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yasuhiro Matsuda, Yosuke Hata, Hiroyuki Uematsu, Toshiaki Mano
Summary: The efficacy of ablation targeting low-voltage areas (LVAs) is controversial, although LVA presence is well known to be associated with atrial fibrillation (AF) recurrence after ablation.
CIRCULATION JOURNAL
(2022)
Article
Engineering, Biomedical
Niels Harlaar, Sven O. Dekker, Juan Zhang, Rebecca R. Snabel, Marieke W. Veldkamp, Arie O. Verkerk, Carla Cofino Fabres, Verena Schwach, Lente J. S. Lerink, Mathilde R. Rivaud, Aat A. Mulder, Willem E. Corver, Marie Jose T. H. Goumans, Dobromir Dobrev, Robert J. M. Klautz, Martin J. Schalij, Gert Jan C. Veenstra, Robert Passier, Thomas J. van Brakel, Daniel A. Pijnappels, Antoine A. F. de Vries
Summary: Functional human atrial myocytes can be massively expanded via a conditional cell-immortalization method, and used in in vitro models of atrial fibrillation. This study successfully generated immortalized cell lines with properties resembling primary atrial myocytes, and used them to create in vitro models of atrial fibrillation, displaying fibrillatory activity consistent with clinical manifestations and responding to antiarrhythmic drugs.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Article
Multidisciplinary Sciences
Christopher O'Shea, James Winter, S. Nashitha Kabir, Molly O'Reilly, Simon P. Wells, Olivia Baines, Laura C. Sommerfeld, Joao Correia, Ming Lei, Paulus Kirchhof, Andrew P. Holmes, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic
Summary: Optical mapping is a widely used technique in pre-clinical cardiac research, allowing for efficient study of cardiac electrophysiology and the effects of interventions on arrhythmia.
Article
Cardiac & Cardiovascular Systems
Remi Chauvel, Nicolas Derval, Josselin Duchateau, Arnaud Denis, Romain Tixier, Nicolas Welte, Clementine Andre, F. Daniel Ramirez, Takashi Nakashima, Yosuke Nakatani, Tsukasa Kamakura, Takamitsu Takagi, Philipp Krisai, Ghassen Cheniti, Konstantinos Vlachos, Felix Bourier, Masateru Takigawa, Takeshi Kitamura, Frederic Sacher, Meleze Hocini, Pierre Jais, Michel Haissaguerre, Thomas Pambrun
Summary: Persistent atrial fibrillation ablation in patients with cardiac laminopathy is challenging due to severe left atrial impairment, resulting in limited ablation effects and high recurrence rates.
Article
Cardiac & Cardiovascular Systems
Fima Macheret, Savannah F. Bifulco, Griffin D. Scott, Kirsten T. Kwan, Yaacoub Chahine, Tanzina Afroze, Rosemary Mcdonagh, Nazem Akoum, Patrick M. Boyle
Summary: This study aims to test whether modulation of conduction velocity in persistent atrial fibrillation (AF) models can improve the agreement between simulation and clinical arrhythmias. The results show that modulation of conduction velocity significantly improves the agreement between models and clinical outcomes, especially in patients with higher body mass index or left atrial fibrosis burden. This finding contributes to better personalized modeling and immediate clinical implications.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Patrick Mueller, Bob Weijs, Nadine M. A. A. Bemelmans, Andreas Muegge, Lars Eckardt, Harry J. G. M. Crijns, Jeroen J. Bax, Dominik Linz, Dennis W. den Uijl
Summary: PA-TDI duration is a crucial parameter for assessing the extent of atrial remodeling, providing a comprehensive reflection of both electrical and structural changes in the atria. It helps identify patients at risk for AF and guide AF management efficiently.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Simon Thibault, Anh-Tuan Ton, Francois Huynh, Celine Fiset
Summary: Men have a higher risk of developing atrial fibrillation than women. This study found that male mice have different atrial electrical and structural properties compared to females, and castration can reduce the susceptibility of male mice to atrial fibrillation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Iosif Karantoumanis, Ioannis Doundoulakis, Stefanos Zafeiropoulos, Kostas Oikonomou, Pantelis Makridis, Christodoulos Pliakos, Haralambos Karvounis, George Giannakoulas
Summary: This study revealed that evaluating total atrial conduction time and left atrial asynchrony can serve as predictors of atrial fibrillation recurrence. Factors such as prolonged conduction time in various left atrial walls and differences in mean PA-TDI values were associated with AF recurrence.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Daisetsu Aoyama, Shinsuke Miyazaki, Kanae Hasegawa, Ryohei Nomura, Shota Kakehashi, Moe Mukai, Machiko Miyoshi, Junya Yamaguchi, Yusuke Sato, Yuichiro Shiomi, Hiroyuki Ikeda, Kentaro Ishida, Hiroyasu Uzui, Hiroshi Tada
Summary: This retrospective study investigates the association between AF activation patterns and clinical outcomes post-ablation. It found that non-paroxysmal AF, larger left atrial size, and higher left atrial activation ratios are predictive factors for AF recurrence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Deborah Nairn, Martin Eichenlaub, Bjoern Mueller-Edenborn, Taiyuan Huang, Heiko Lehrmann, Claudia Nagel, Luca Azzolin, Giorgio Luongo, Rosa M. Figueras Ventura, Barbara Rubio Forcada, AnnaValles Colomer, Dirk Westermann, Thomas Arentz, Olaf Doessel, Axel Loewe, Amir Jadidi
Summary: This study compares different detection methods for atrial cardiomyopathy and finds that the new image intensity threshold method improves diagnostic consistency. These methods may help predict rhythm outcomes after treatment for persistent atrial fibrillation.