Article
Cardiac & Cardiovascular Systems
Joshua E. Gonzalez, William H. Cooke
Summary: In this study, inhalation of the JUUL e-cigarette with nicotine increased mean arterial pressure and heart rate, while decreasing muscle sympathetic nerve activity. However, inhaling on a placebo e-cigarette without nicotine did not have the same effects. This study is the first to report similar responses to tobacco cigarettes while inhaling on an e-cigarette.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Melanie Dani, Patricia Taraborrelli, Dimitrios Panagopoulos, Andreas Dirksen, Miriam Torocastro, Richard Sutton, Phang Boon Lim
Summary: This article discusses the baroreflex mechanism in blood pressure regulation in older people, as well as the physiological and pathological reasons for its impairment. Additionally, it explores the causes of orthostatic hypotension and supine hypertension in older individuals, along with strategies for managing these conditions.
Review
Clinical Neurology
Alejandra Gonzalez-Duarte, Aditi Varma-Doyle, Roy Freeman
Summary: PAF is a peripheral autonomic neurodegenerative disease caused by alpha-synuclein deposition, with chronic features of autonomic failure. Diagnostic biomarkers include skin immunohistochemistry for alpha-synuclein and measuring cerebrospinal fluid alpha-synuclein oligomers. A considerable number of PAF patients may convert to a central alpha-synucleinopathy.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jing-Jing Zhou, Jian-Ying Shao, Shao-Rui Chen, Hui-Lin Pan
Summary: This study revealed that calcineurin inhibitor-induced hypertension may be caused by the modulation of NMDA receptor activity in the paraventricular nucleus of the hypothalamus, leading to increased sympathetic output. Therefore, targeting NMDA receptor activity could be a potential therapeutic approach for treating this type of hypertension.
CIRCULATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Review
Clinical Neurology
Jens Jordan, Ulrich Limper, Jens Tank
Summary: This review provides an overview of human autonomic research under real and simulated space conditions, with a focus on orthostatic intolerance. Postflight orthostatic intolerance is commonly observed in astronauts and could pose major risks during landing. In addition, this research has implications for patients with disorders affecting cardiovascular autonomic control on Earth.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
John C. Ehlen, Cassadi M. Forman, Daniela Ostrowski, Tim D. Ostrowski
Summary: This study assessed the influence of Alzheimer's disease on baroreflex function using an animal model. The results showed that the sympathetic nervous system was primarily affected, which may correlate with orthostatic hypotension in human Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Editorial Material
Peripheral Vascular Disease
Jens Jordan, Italo Biaggioni, Vasilios Kotsis, Peter Nilsson, Guido Grassi, Artur Fedorowski, Kazuomi Kario
Summary: We propose a consensus definition for exaggerated orthostatic pressor response, defined as an increase in systolic blood pressure of >= 20 mmHg when transitioning from supine to standing posture. This definition can also be applied to seated to standing measurements. The term orthostatic hypertension is reserved for cases where this pressor response leads to an upright systolic blood pressure of >= 140 mmHg. We believe this consensus definition will aid in the study of pathophysiology, clinical impact, potential treatment, and identification of higher cardiovascular risk patients.
HYPERTENSION RESEARCH
(2023)
Review
Behavioral Sciences
Nicholas V. Alen, Grant S. Shields, Adele Nemer, Indira A. D'souza, Marcela J. Ohlgart, Camelia E. Hostinar
Summary: Parental socialization may influence the development of children's autonomic nervous system, particularly the parasympathetic nervous system. A meta-analysis revealed that positive parenting is positively associated with higher resting parasympathetic nervous system activity in children. This association is more pronounced in experimental studies and when the sample includes children with a clinical condition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Geriatrics & Gerontology
Siddhartha Lieten, Aziz Debain, Bert Bravenboer, Tony Mets
Summary: This case demonstrates the use of continuous blood pressure registration in diagnosing nocturnal hypertension in geriatric patients with orthostatic hypotension. It illustrates the usefulness of 18-FDG PET brain CT scan in specifying the nature of autonomic failure. The case also highlights the challenges in managing the combination of orthostatic hypotension and nocturnal hypertension.
Article
Clinical Neurology
Anne Pavy-Le Traon, Alexandra Foubert-Samier, Fabienne Ory-Magne, Margherita Fabbri, Jean-Michel Senard, Wassilios G. Meissner, Olivier Rascol, Jacques Amar
Summary: This study investigated the association between mortality, 24-hour blood pressure level and variability, and drug treatments for orthostatic hypotension (OH) in patients with multiple system atrophy (MSA). The results showed that increased daytime blood pressure variability and OH treatment were independently predictive of mortality in MSA patients, regardless of disease severity.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J. Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A. Mendiola Pla, Dawn E. Bowles, Andreas M. Beyer, Xinping Yue, Eric Lazartigues, Catalin M. Filipeanu
Summary: This study aimed to identify E3 ubiquitin ligases associated with ACE2 ubiquitination in neurogenic hypertension and establish their clinical relevance. By combining bioinformatics and proteomics, the researchers were able to identify Nedd4-2 as the first E3 ubiquitin ligase involved in ACE2 ubiquitination in Ang-II-mediated hypertension. They also demonstrated the important role of ACE2 in GABAergic neurons in maintaining inhibitory tone and regulating pre-sympathetic activity. These findings provide a new understanding of the development of neurogenic hypertension and potential therapeutic strategies. Rating: 9/10.
CARDIOVASCULAR RESEARCH
(2023)
Article
Physiology
Mohammad Soltani, Masoud Jokar Baluchi, Daniel Boullosa, Ali Daraei, Patricia K. Doyle-Baker, Ayoub Saeidi, Beat Knechtle, Kambiz Moradi Dehbaghi, Shirin Shirzad Mollabashi, Trisha A. VanDusseldorp, Hassane Zouhal
Summary: This study investigated the chronic effects of high-volume moderate-intensity training (HVMIT) and low-volume high-intensity training (LVHIT) on heart rate variability (HRV) and arterial stiffness (AS) in sedentary adult men. LVHIT protocol was more efficient for improving HRV variables and PWV than HVMIT protocol after 12 weeks of continuous running training. Changes in some HRV parameters were related to changes in PWV, suggesting a potential link between central and peripheral cardiovascular adaptations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Luis E. Okamoto, Jorge E. Celedonio, Emily C. Smith, Sachin Y. Paranjape, Bonnie K. Black, Amr Wahba, Jin-Woo Park, Cyndya A. Shibao, Andre Diedrich, Italo Biaggioni
Summary: We conducted two studies and found that continuous positive airway pressure (CPAP) can effectively reduce nocturnal supine hypertension in patients with autonomic failure, improve nocturia and symptoms of daytime orthostatic hypotension.
Review
Biochemistry & Molecular Biology
Matei Daniela, Luca Catalina, Onu Ilie, Matei Paula, Iordan Daniel-Andrei, Buculei Ioana
Summary: Studies show that the autonomic nervous system has a significant impact on overall health. In modern societies, an unhealthy lifestyle contributes to dysfunction in this system. While physical exercise has well-known positive effects on health, its negative impact needs to be studied further.
Article
Geriatrics & Gerontology
Kumiko Nagai, Hitomi Koshiba, Shigeki Shibata, Toshifumi Matsui, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2015)
Article
Neurosciences
Yoshiyuki Okada, Stuart A. Best, Sara S. Jarvis, Shigeki Shibata, Rosemary S. Parker, Brian M. Casey, Benjamin D. Levine, Qi Fu
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Article
Cardiac & Cardiovascular Systems
Shuaib M. Abdullah, Kyler W. Barkley, Paul S. Bhella, Jeffrey L. Hastings, Susan Matulevicius, Naoki Fujimoto, Shigeki Shibata, Graeme Carrick-Ranson, M. Dean Palmer, Nainesh Gandhi, Laura F. DeFina, Benjamin D. Levine
CIRCULATION-CARDIOVASCULAR IMAGING
(2016)
Article
Physiology
Graeme Carrick-Ranson, Naoki Fujimoto, Keri M. Shafer, Jeffrey L. Hastings, Shigeki Shibata, M. Dean Palmer, Kara Boyd, Benjamin D. Levine
JOURNAL OF APPLIED PHYSIOLOGY
(2016)
Article
Geriatrics & Gerontology
Toshimasa Obara, Kumiko Nagai, Shigeki Shibata, Ai Hirasawa, Hitomi Koshiba, Hiroshi Hasegawa, Takae Ebihara, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2018)
Article
Physiology
Michinari Hieda, Erin Howden, Shigeki Shibata, Takashi Tarumi, Justin Lawley, Christopher Hearon, Dean Palmer, Qi Fu, Rong Zhang, Satyam Sarma, Benjamin D. Levine
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Neurosciences
Shigeki Shibata, Naoki Fujimoto, Jeffrey L. Hastings, Graeme Carrick-Ranson, Paul S. Bhella, Christopher M. Hearon, Benjamin D. Levine
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Physiology
Taiki Miyazawa, Shigeki Shibata, Kumiko Nagai, Ai Hirasawa, Yoshio Kobayashi, Hitomi Koshiba, Koichi Kozaki
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Michinari Hieda, Erin Howden, Shigeki Shibata, Naoki Fujimoto, Paul S. Bhella, Jeffrey L. Hastings, Takashi Tarumi, Satyam Sarma, Qi Fu, Rong Zhang, Benjamin D. Levine
Article
Geriatrics & Gerontology
Graeme Carrick-Ranson, Francis G. Spinale, Paul S. Bhella, Satyam Sarma, Shigeki Shibata, Naoki Fujimoto, Jeffrey L. Hastings, Benjamin D. Levine
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Qi Fu, Shigeki Shibata, Jeffrey L. Hastings, Steven H. Platts, Douglas M. Hamilton, Michael W. Bungo, Michael B. Stenger, Christine Ribeiro, Beverley Adams-Huet, Benjamin D. Levine
Article
Physiology
Shigehiko Ogoh, Kazuya Suzuki, Takuro Washio, Kazuki Tamiya, Shotaro Saito, Tom G. Bailey, Shigeki Shibata, Go Ito, Tadayoshi Miyamoto
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Clinical Neurology
Chueh-Lung Hwang, Kazunobu Okazaki, Shigeki Shibata, Yu-Lun Liu, Qi Fu
Summary: This study investigated the effects of the menstrual cycle on muscle sympathetic nerve activity burst amplitude distribution during an orthostatic challenge in young women. The results showed that the mean and median values of relative burst amplitude increased from supine to upright position, regardless of menstrual cycle phases. However, the skewness and kurtosis of burst amplitude distribution varied between the early follicular phase and mid-luteal phase.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Shinya Matsushima, Minoru Yoshida, Hitoshi Yokoyama, Yosuke Watanabe, Hidetaka Onodera, Haruaki Wakatake, Hiroki Saito, Masahiko Kimura, Shigeki Shibata
Summary: The study showed that critically ill patients in the ICU with higher protein intake had better muscle strength at discharge and recovered to independent walking faster compared to those with lower protein intake.
Article
Physiology
Yoshiyuki Okada, Shigeki Shibata, Naoki Fujimoto, Stuart A. Best, Benjamin D. Levine, Qi Fu
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2017)