Article
Pharmacology & Pharmacy
Shengnan Liu, Chao Zhang, Jing Wan
Summary: This retrospective cohort study observed the incidence of major adverse cardiovascular events (MACE) in hypertensive patients and the correlation between electrocardiogram (ECG) T-wave abnormalities and echocardiographic changes. The results showed that hypertensive patients with abnormal T-wave had a significantly higher incidence of adverse cardiovascular events. In addition, cardiac structural markers were significantly higher in the group with abnormal T-wave.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer A. Davidson, Amitava Banerjee, Ian Douglas, Clemence Leyrat, Richard Pebody, Helen McDonald, Emily Herrett, Harriet Forbes, Liam Smeeth, Charlotte Warren-Gash
Summary: This study reveals that the incidence of first myocardial infarction and stroke is reduced 1-3 months after influenza vaccination. However, it is still unclear how underlying cardiovascular risk affects this association.
EUROPEAN HEART JOURNAL
(2023)
Article
Neurosciences
Avinash Kondiboyina, Hilary A. Harrington, Joseph J. Smolich, Michael M. H. Cheung, Jonathan P. Mynard
Summary: The arterial network in healthy young adults is structured to optimize wave reflection, and a new model has been developed that accurately reproduces the typical waveform morphology observed in young adults, providing important insights for studying cardiovascular changes in aging and disease states.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Cardiac & Cardiovascular Systems
Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
Summary: Notched P-waves on digital electrocardiogram are associated with cardiovascular events and left atrial enlargement.
Article
Oncology
Anna Astarita, Giulia Mingrone, Lorenzo Airale, Fabrizio Vallelonga, Michele Covella, Cinzia Catarinella, Marco Cesareo, Giulia Bruno, Dario Leone, Carlo Giordana, Giusy Cetani, Marco Salvini, Francesca Gay, Sara Bringhen, Franco Rabbia, Franco Veglio, Alberto Milan
Summary: Although a relationship between Carfilzomib (CFZ) therapy in multiple myeloma (MM) and cardiovascular adverse events (CVAEs) exists, there is currently a lack of specific validated protocols for cardiovascular risk assessment. This prospective study investigated major predictors of CVAEs before starting CFZ therapy, and identified five predictors to estimate the baseline risk of CVAEs with a 'CVAEs risk score'. The study found that CVAEs are frequent, emphasizing the need for a specific management protocol for patients undergoing CFZ therapy. The European Myeloma Network protocol and risk score were effective in identifying higher-risk patients and guiding appropriate follow-up.
Article
Cardiac & Cardiovascular Systems
Junayd Hussain, Haris Imsirovic, Mark Canney, Edward G. Clark, Meghan J. Elliott, Pietro Ravani, Peter Tanuseputro, Ayub Akbari, Gregory L. Hundemer, Tim Ramsay, Navdeep Tangri, Greg A. Knoll, Manish M. Sood
Summary: This study found that subclinical reductions in kidney function in young adults are associated with an increased cardiovascular risk. The relative risk of major adverse cardiovascular events (MACE) and MACE plus heart failure (MACE+) was higher in young adults with eGFR below age-expected values. Age-appropriate risk stratification, proactive monitoring, and timely intervention are warranted.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Veterinary Sciences
Tomohiko Yoshida, Katsuhiro Matsuura, Goya Seijirow, Akiko Uemura, Zeki Yilmaz, Ryou Tanaka
Summary: This study investigated the non-invasive assessment of pulmonary arterial wave reflection in dogs with suspected pulmonary hypertension using Doppler echocardiography. The results showed that dogs with suspected PH had significantly higher RC than dogs without echocardiographic evidence of PH, and dogs with higher RC had shorter survival times. The study also validated the correlation between RC obtained by Doppler echocardiography and RC obtained by cardiac catheterization in dogs with experimentally-induced PH.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Peripheral Vascular Disease
William B. Earle, Jordan K. Kondo, Karla N. Kendrick, Ruth-Alma Turkson-Ocran, Long Ngo, Jennifer L. Cluett, Kenneth J. Mukamal, Natalie Daya Malek, Elizabeth Selvin, Pamela L. Lutsey, Josef Coresh, Stephen P. Juraschek
Summary: This study compares the long-term clinical consequences of supine hypertension and standing hypotension among middle-aged adults.
Article
Cardiac & Cardiovascular Systems
Shishir Rao, Milad Nazarzadeh, Dexter Canoy, Yikuan Li, Jing Huang, Mohammad Mamouei, Gholamreza Salimi-Khorshidi, Aletta E. Schutte, Bruce Neal, George Davey Smith, Kazem Rahimi
Summary: This study analyzed health data from 475,442 individuals in the UK aged 60-90 who had at least one prescription of paracetamol. It found that paracetamol formulations containing sodium bicarbonate were associated with increased blood pressure, cardiovascular diseases, and all-cause mortality. However, further analysis showed that this association was primarily due to confounding by indication related to dysphagia and related conditions. Therefore, this study concludes that short-term use of sodium bicarbonate paracetamol in routine clinical practice does not increase the risk of elevated blood pressure and cardiovascular events.
EUROPEAN HEART JOURNAL
(2023)
Article
Oncology
Giulia Mingrone, Anna Astarita, Anna Colomba, Cinzia Catarinella, Marco Cesareo, Lorenzo Airale, Arianna Paladino, Dario Leone, Fabrizio Vallelonga, Sara Bringhen, Francesca Gay, Franco Veglio, Alberto Milan
Summary: The study provides practical insight on the prevention and management of cardiovascular adverse events during carfilzomib therapy, based on the experience of a specialized center in managing patients with increased cardiovascular risk. They propose a management protocol for cardiovascular adverse events based on presenting symptoms and provide decision-making support for health professionals in selecting the best management strategies.
Article
Physiology
Tomohiko Yoshida, Tokuhisa Uejima, Syunta Komeda, Katsuhiro Matsuura, Akiko Uemura, Hiromasa Hayama, Takeshi Yamashita, Zeki Yilmaz, Ryou Tanaka
Summary: The Doppler echocardiography method provides a reasonable measurement of reflected waves in the pulmonary circulation, paving the way for a more integrative assessment of pulmonary hemodynamics in the clinical setting.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sobhan Salari Shahrbabaki, Dominik Linz, Mathias Baumert
Summary: This study aims to evaluate the association between nocturnal temporal pulse wave amplitude attenuations and cardiovascular events. The results show that nocturnal pulse wave amplitude attenuation is inversely associated with cardiovascular risk, particularly in men and African-Americans.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chang Hee Kwon, Woohyeun Kim, Jeong-Hun Shin, Chan Joo Lee, Hyeon-Chang Kim, Si-Hyuck Kang, Mi-Hyang Jung, Dae-Hee Kim, Ju-Hee Lee, Hack Lyoung Kim, Hyue Mee Kim, In Jeong Cho, Iksung Cho, Dae Ryong Kang, Hae-Young Lee, Wook-Jin Chung, Sang-Hyun Ihm, Kwang Il Kim, Eun Joo Cho, Il-Suk Sohn, Sungha Park, Jinho Shin, Sung Kee Ryu, Seok-Min Kang, Myeong-Chan Cho, Ju Han Kim, Jun Hyeok Lee, Jang-Young Kim, Wook Bum Pyun, Ki-Chul Sung
Summary: The study found that blood pressure levels are significantly correlated with the risk of major cardiovascular events (MACE) in Korean patients with hypertension, with no additional benefits observed for MACE among those treated for hypertension with a BP <120/70 mm Hg.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Oncology
Sunnia T. Chen, Leylah Azali, Lindsay Rosen, Qiuhong Zhao, Tracy Wiczer, Marilly Palettas, John Gambril, Onaopepo Kola-Kehinde, Patrick Ruz, Sujay Kalathoor, Kerry Rogers, Adam Kittai, Michael Grever, Farrukh Awan, John C. Byrd, Jennifer Woyach, Seema A. Bhat, Daniel Addison
Summary: This study aimed to evaluate the association between first-generation Bruton's tyrosine kinase inhibitor (BTKi) therapy, ibrutinib, and novel selective second-generation BTKi therapy, acalabrutinib, with hypertension. The results showed that nearly half of the patients treated with acalabrutinib developed new or worsened hypertension. Furthermore, early systolic blood pressure increase was associated with an increased risk of major cardiovascular events.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiao Wang, Zhimin Wang, Feng Guo, Yinghui Zhang, Hongfei Ji, Gang Chen, Qin Wan, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Lixin Shi, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Li Chen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Mian Li, Yu Xu, Min Xu, Zhiyun Zhao, Tiange Wang, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Yanyan Zhao, Guijun Qin
Summary: Diabetes, hypertension, and dyslipidemia are associated with an increased risk of cardiovascular events in middle-aged and elderly Chinese adults, and the risk is further elevated when these conditions coexist.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Robert Clarke, Adam Von Ende, Lukas E. Schmidt, Xiaoke Yin, Michael Hill, Alun D. Hughes, Raimund Pechlaner, Johann Willeit, Stefan Kiechl, Hugh Watkins, Konstantinos Theofilatos, Jemma C. Hopewell, Manuel Mayr
Summary: This study assessed the relevance of 13 apolipoproteins measured using a single mass-spectrometry assay for risk of coronary heart disease (CHD), and found that some apolipoproteins were independently associated with CHD. These results suggest that apolipoproteins could help identify patients with residual lipid-related risk and guide personalized approaches to CHD risk reduction.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xilin Wu, Russell Senanayake, Emily Goodchild, Waiel A. Bashari, Jackie Salsbury, Claudia P. Cabrera, Giulia Argentesi, Samuel M. O'Toole, Matthew Matson, Brendan Koo, Laila Parvanta, Nick Hilliard, Vasilis Kosmoliaptsis, Alison Marker, Daniel M. Berney, Wilson Tan, Roger Foo, Charles A. Mein, Eva Wozniak, Emmanuel Savage, Anju Sahdev, Nicholas Bird, Kate Laycock, Istvan Boros, Stefan Hader, Victoria Warnes, Daniel Gillett, Anne Dawnay, Elizabeth Adeyeye, Alessandro Prete, Angela E. Taylor, Wiebke Arlt, Anish N. Bhuva, Franklin Aigbirhio, Charlotte Manisty, Alasdair McIntosh, Alexander McConnachie, J. Kennedy Cruickshank, Heok Cheow, Mark Gurnell, William M. Drake, Morris J. Brown
Summary: Primary aldosteronism (PA) caused by a unilateral aldosterone-producing adenoma is a common cause of hypertension. Adrenal surgery can provide a cure or significant improvement, but the invasive nature of the pre-surgical investigation limits the number of patients who can receive this treatment. This study compared the accuracy of a non-invasive test, [C-11]metomidate positron emission tomography computed tomography (MTO) scanning, with adrenal vein sampling (AVS) in predicting the success of surgery in patients with PA.
Article
Geriatrics & Gerontology
Rahul Chandrasekar, Rebecca E. Lacey, Nishi Chaturvedi, Alun D. Hughes, Praveetha Patalay, Amal R. Khanolkar
Summary: This study aimed to investigate the impact of adverse childhood experiences (ACE) on rates and development of multimorbidity over three decades in adulthood. The results showed that the accumulation of psychosocial and childhood health ACEs were associated with progressively higher multimorbidity scores throughout the follow-up. All three grouped ACEs were associated with greater rates of accumulation and higher multimorbidity trajectories across adulthood.
Article
Cardiac & Cardiovascular Systems
Adam Ioannou, Rishi K. Patel, Ana Martinez-Naharro, Yousuf Razvi, Aldostefano Porcari, David F. Hutt, Francesco Bandera, Tushar Kotecha, Lucia Venneri, Liza Chacko, Paolo Massa, Melissa Hanger, Daniel Knight, Charlotte Manisty, James Moon, Cristina Quarta, Helen Lachmann, Carol Whelan, Peter Kellman, Philip N. Hawkins, Julian D. Gillmore, Ashutosh Wechelakar, Marianna Fontana
Summary: This study aims to assess multiorgan response to treatment using extracellular volume (ECV) mapping and examine the association between multiorgan treatment response and prognosis.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel A. Jones, Anne-Marie Beirne, Matthew Kelham, Krishnaraj S. Rathod, Mervyn Andiapen, Lucinda Wynne, Thomas Godec, Nasim Forooghi, Rohini Ramaseshan, James C. Moon, Ceri Davies, Christos V. Bourantas, Andreas Baumbach, Charlotte Manisty, Andrew Wragg, Amrita Ahluwalia, Francesca Pugliese, Anthony Mathur, BYPASS-CTCA Trial Comm Investigators
Summary: This study assessed the benefit of computed tomography cardiac angiography (CTCA) in patients with previous coronary artery bypass grafting referred for invasive coronary angiography (ICA). The results showed that CTCA before ICA led to reductions in procedure time and contrast-induced nephropathy, with improved patient satisfaction.
Article
Cardiac & Cardiovascular Systems
George Joy, Christopher I. Kelly, Matthew Webber, Iain Pierce, Irvin Teh, Louise Mcgrath, Paula Velazquez, Rebecca K. Hughes, Huafrin Kotwal, Arka Das, Fiona Chan, Athanasios Bakalakos, Massimiliano Lorenzini, Konstantinos Savvatis, Saidi A. Mohiddin, Peter W. Macfarlane, Michele Orini, Charlotte Manisty, Peter Kellman, Rhodri H. Davies, Pier D. Lambiase, Christopher Nguyen, Jurgen E. Schneider, Maite Tome, Gabriella Captur, Erica Dall'Armellina, James C. Moon, Luis R. Lopes
Summary: In patients with hypertrophic cardiomyopathy, alterations in myocardial microstructure and microvascular disease have been found to occur early in the disease process. These changes serve as potential early phenotype biomarkers for disease detection and management.
Article
Peripheral Vascular Disease
Hannah C. M. Taylor, Nishi Chaturvedi, George Davey Smith, Diana L. S. Ferreira, Abigail Fraser, Laura D. Howe, Alun D. Hughes, Debbie A. Lawlor, Nic J. Timpson, Chloe M. Park
Summary: This study investigated the appropriate allometric scaling relationships between left ventricular mass (LVM) and height, total lean mass, and body surface area in healthy adolescents. The results suggest that pooled data without adjustment for sex may introduce bias in allometric scaling estimates. Clinicians should consider body size, body composition, sex, and age when assessing left ventricular mass.
Review
Cardiac & Cardiovascular Systems
David Bann, Liam Wright, Alun Hughes, Nish Chaturvedi
Summary: Socioeconomic inequalities in cardiovascular disease persist despite overall declines in morbidity and mortality. The causality between low socioeconomic position (SEP) and CVD is still uncertain. Traditional observational, family-based, and Mendelian randomization studies support the causal influence of low SEP on CVD, while quasi-experimental and experimental studies have mixed and limited results. More research is needed to understand the causal relationship and inform policy.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lamia Al Saikhan, Chloe Park, Therese Tillin, Siana Jones, Jamil Mayet, Nish Chaturvedi, Alun Hughes
Summary: 3D-speckle tracking echocardiography (3D-STE) can predict cardiac events beyond conventional risk factors in the general population. The strain measurements derived from 3D-STE showed slight improvement in predictive value compared to traditional 3D ejection fraction.
Article
Multidisciplinary Sciences
Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Aine Mcknight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Rosemary J. Boyton
Summary: This study analyzes the immune response in healthcare workers with mild or asymptomatic SARS-CoV-2 infection and compares it to those with Long Covid. The results show no significant differences in immune responses between the two groups up to 18 weeks post-infection and 1 year after vaccination, suggesting that immune response variations are unlikely to be a contributing factor to Long Covid development.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Michele Orini, Stefan van Duijvenboden, William J. Young, Julia Ramirez, Aled R. Jones, Alun D. Hughes, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
Summary: The study aimed to investigate the association between ultra-short heart rate variability (usHRV) and cardiovascular events. By measuring usHRV using standard and wearable ECGs, and associating it with individuals without cardiovascular disease, the study found that usHRV correlates with standard short-term HRV and predicts increased risk of cardiovascular events.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Ivan Stankovic, Jens-Uwe Voigt, Haran Burri, Denisa Muraru, Leyla Elif Sade, Kristina Hermann Haugaa, Joost Lumens, Mauro Biffi, Jean-Nicolas Dacher, Nina Ajmone Marsan, Elise Bakelants, Charlotte Manisty, Marc R. Dweck, Otto A. Smiseth, Erwan Donal
Summary: Cardiovascular imaging plays different roles in patients considering CIED and in CIED recipients. It helps identify causes, assess risks, and guide lead placements in patients considering CIED, while it is used to evaluate device response, detect complications, and optimize devices in CIED recipients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ivan Stankovic, Jens-Uwe Voigt, Haran Burri, Denisa Muraru, Leyla Elif Sade, Kristina Hermann Haugaa, Joost Lumens, Mauro Biffi, Jean-Nicolas Dacher, Nina Ajmone Marsan, Elise Bakelants, Charlotte Manisty, Marc R. Dweck, Otto A. Smiseth, Erwan Donal
Summary: This study provides guidance on the use of imaging after implantation of cardiac pacemakers and cardiac resynchronization therapy devices, covering the diagnosis and management of CIED-related complications, as well as the optimal use of various cardiac imaging modalities in patients with CIED implants.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Constantin-Cristian Topriceanu, Eesha Dev, Mahmood Ahmad, Rebecca Hughes, Hunain Shiwani, Matthew Webber, Kenan Direk, Andrew Wong, Martin Ugander, James C. Moon, Alun D. Hughes, Jane Maddock, Todd T. Schlegel, Gabriella Captur
Summary: This study investigates the relationship between DNAm age and A-ECG heart age, and finds that DNAm AgeAccel is associated with cardiovascular risk factors. The results suggest that participants with accelerated DNA methylation at the age of 60 may have older, weaker, and more electrically impaired hearts. Furthermore, the harmful effects of cardiovascular risk factors on cardiac age and health may be partially mediated by DNAm AgeAccel.
CLINICAL EPIGENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Adam Ioannou, Rishi K. Patel, Ana Martinez-Naharro, Yousuf Razvi, Aldostefano Porcari, Muhammad U. Rauf, Roos E. Bolhuis, Jacob Fernando-Sayers, Ruta Virsinskaite, Francesco Bandera, Tushar Kotecha, Lucia Venneri, Daniel Knight, Charlotte Manisty, James Moon, Helen Lachmann, Carol Whelan, Peter Kellman, Philip N. Hawkins, Julian D. Gillmore, Ashutosh Wechalekar, Marianna Fontana
Summary: This study evaluated the effectiveness of native T1 mapping in measuring cardiac treatment response in patients with cardiac light-chain amyloidosis and found that changes in native T1 were associated with changes in traditional markers of cardiac response and mortality.