Article
Cardiac & Cardiovascular Systems
C. H. Lee, M. Z. Wu, D. T. W. Lui, C. H. Y. Fong, Q. W. Ren, S. Y. Yu, M. M. A. Yuen, W. S. Chow, J. Y. Huang, A. Xu, K. H. Yiu, K. S. L. Lam
Summary: This study found that serum TSP2 levels were independently associated with incident heart failure and deterioration in diastolic function in patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Youn-Hoa Jung, Xianfeng Ren, Giancarlo Suffredini, Jeffery M. Dodd-o, Wei Dong Gao
Summary: This manuscript reviews issues related to right ventricular diastolic dysfunction and failure, including diagnosis, mechanisms, clinical impact, and management, highlighting its importance as a sensitive marker of end-organ dysfunction.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
T. Jake Samuel, Dalane W. Kitzman, Mark J. Haykowsky, Bharathi Upadhya, Peter Brubaker, M. Benjamin Nelson, W. Gregory Hundley, Michael D. Nelson
Summary: The study revealed that LV circumferential early diastolic strain rate was impaired in older obese patients with HFpEF compared to controls, and there was only modest correlation between LV relaxation and reduced peak (V)over dotO(2). On the other hand, it showed a stronger relationship between elevated LV filling pressures and exercise intolerance in determining future therapeutic priorities.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Nobuhiro Ikemura, Koki Nakanishi, John A. Spertus, Carolyn S. P. Lam, Takehiro Kimura, Yoshinori Katsumata, Taishi Fujisawa, Ikuko Ueda, Takahiro Ohki, Keiichi Fukuda, Seiji Takatsuki, Shun Kohsaka
Summary: This study aimed to investigate whether indices of left ventricular diastolic dysfunction (LVDD) can stratify AF patients without a clinical history of HF. The results showed that the presence of LVDD was associated with adverse clinical outcomes and patients' perceived health status.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Andrey Lozhkin, Aleksandr E. Vendrov, R. Ramos-Mondragon, Chandrika Canugovi, Mark D. Stevenson, Todd J. Herron, Scott L. Hummel, C. Alberto Figueroa, Dawn E. Bowles, Lori L. Isom, Marschall S. Runge, Nageswara R. Madamanchi
Summary: This study suggests that mitochondrial oxidative stress contributes to diastolic dysfunction by causing mitochondrial dysfunction, impaired mitochondrial dynamics, increased synthesis of pro-inflammatory and pro-fibrotic cytokines, activation of fibroblasts, and the accumulation of extracellular matrix, resulting in interstitial fibrosis and passive stiffness of the myocardium.
Review
Biotechnology & Applied Microbiology
Sona M. Al Younis, Leontios J. Hadjileontiadis, Cesare Stefanini, Ahsan H. Khandoker
Summary: This article explores innovative methods for the early diagnosis and classification of heart failure using non-invasive sensor-based technologies. These technologies have significantly advanced cardiac care by enabling research, early detection, and support for clinical decision-making. The article discusses validated enhancements, challenges, and future trends in heart failure and dysfunction modeling, with a focus on non-invasive sensing technologies. The methodologies identified in the article highlight the importance of non-contact sensing setups and machine learning approaches in home, remote, and continuous monitoring of myocardial performance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew J. Fletcher, Winok Lapidaire, Paul Leeson
Summary: Current clinical guidelines recommend using echocardiography measures to assess cardiac diastolic function, but this method has limitations including suboptimal accuracy, indeterminate classifications, and susceptibility to confounding from comorbidities. Recent advances in artificial intelligence offer revolutionary ways to accurately evaluate cardiac function using large quantities of data, particularly in the imaging sub-field of machine-learning.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Genri Numata, Eiki Takimoto, Taro Kariya, Yusuke Adachi, Hiroyuki Tokiwa, Masayuki Toyoda, Ryo Mafune, Yoshihiro Saito, Shun Nakamura, Kazutaka Ueda, Yuichi Ikeda, Issei Komuro
Summary: HFpEF is a global health issue with a lack of stable methods for detecting diastolic dysfunction in mouse models. The authors developed a pacing-controlled protocol to evaluate diastolic function at different heart rates in mice and successfully detected diastolic dysfunction specific to an HFpEF model.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Pediatrics
Bo Pan, Di Hu, Huichao Sun, Tiewei Lv, Wangguo Xu, Jie Tian
Summary: This study summarized the differences between pediatric diastolic heart failure and systolic heart failure in terms of primary causes, clinical features, and short-term prognosis. B-type natriuretic peptide has limited diagnostic value in pediatric DHF. Diastolic function indicators significantly improved after treatment in DHF patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Seul-Gee Lee, Darae Kim, Jung-Jae Lee, Hyun-Ju Lee, Ro-Kyung Moon, Yong-Joon Lee, Seung-Jun Lee, Oh-Hyun Lee, Choongki Kim, Jaewon Oh, Chan Joo Lee, Yong-Ho Lee, Seil Park, Ok-Hee Jeon, Donghoon Choi, Geu-Ru Hong, Jung-Sun Kim
Summary: In a diabetic animal model, dapagliflozin attenuated left ventricular diastolic dysfunction and cardiac fibrosis through regulation of SGK1 signaling. It also exhibited anti-inflammatory effects and ameliorated mitochondrial disruption.
Article
Cardiac & Cardiovascular Systems
Gabor A. Fulop, Attila Olah, Tamas Csipo, Arpad Kovacs, Robert Porszasz, Roland Veress, Balazs Horvath, Laszlo Nagy, Beata Bodi, Miklos Fagyas, Solveig Lind Helgadottir, Viktor Banhegyi, Bela Juhasz, Mariann Bombicz, Daniel Priksz, Peter Nanasi, Bela Merkely, Istvan Edes, Zoltan Csanadi, Zoltan Papp, Tamas Radovits, Attila Toth
Summary: Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility, but may have previously unrecognized side effects. Concentration-dependent improvements in cardiac function were observed with OM, although higher concentrations were associated with hypotension and diastolic dysfunction.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ambarish Pandey, Nobuyuki Kagiyama, Naveena Yanamala, Matthew W. Segar, Jung S. Cho, Marton Tokodi, Partho P. Sengupta
Summary: The study developed a DeepNN model to predict high- and low-risk phenogroups in a derivation cohort, with validation in external cohorts to assess its accuracy in predicting left ventricular filling pressure. Results showed that the model outperformed current guidelines in predicting elevated filling pressure and identified specific patient subgroups with adverse outcomes and potential spironolactone response.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Maria Francesca Evaristi, Bruno Poirier, Xavier Chenede, Anne-Marie Lefebvre, Alain Roccon, Florence Gillot, Sandra Beeske, Alain Corbier, Marie-Pierre Pruniaux-Harnist, Philip Janiak, Ashfaq A. Parkar
Summary: The study found that SAR247799 can improve LVH and diastolic function, two major components of HFpEF. The drug can slow down cardiac hypertrophy and improve endothelial function.
Article
Multidisciplinary Sciences
Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
Summary: This study investigated the effects of coronary risk factors on left ventricular size and cardiac function using structure equation modeling. It found that each risk factor directly affected the shape of the heart. Managing risk factors is crucial in reducing the heart failure pandemic, as vascular risk and heart failure risk are likely to evolve simultaneously.
SCIENTIFIC REPORTS
(2021)
