Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Julien Ternacle, Asim N. Cheema, Francisco Campelo-Parada, Marina Urena, Gabriela Veiga-Fernandez, Luis Nombela-Franco, Antonio J. Munoz-Garcia, Victoria Vilalta, Ander Regueiro, David del Val, Lluis Asmarats, Maria del Trigo, Vicenc Serra, Guillaume Bonnet, Melchior Jonveaux, Effat Rezaei, Anthony Matta, Dominique Himbert, Jose Maria de la Torre Hernandez, Gabriela Tirado-Conte, Eduard Fernandez-Nofrerias, Pablo Vidal, Fernando Alfonso, Lola Gutierrez-Alonso, Juan Francisco Oteo, Yassin Belahnech, Siamak Mohammadi, Francois Philippon, Thomas Modine, Josep Rodes-Cabau
Summary: This study evaluated the incidence and predictors of heart failure-related death and sudden cardiac death in patients undergoing TAVR. The results showed that heart failure and sudden cardiac death accounted for a significant portion of deaths after TAVR. Several factors, including atrial fibrillation and prior pacemaker, were associated with heart failure-related death, while valve-in-valve TAVR and transarterial nontransfemoral approach were associated with sudden cardiac death.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Jun Shi, Lai Wei, Yucheng Chen, Xu Wang, Jian Ye, Chaoyi Qin, Lulu Liu, Hong Qian, Chunsheng Wang, Yingqiang Guo
Summary: The study showed good midterm outcomes of transcatheter aortic valve implantation with the J-Valve system in treating patients with aortic stenosis or pure aortic insufficiency, suggesting it as a promising alternative therapy for high-risk patients.
ANNALS OF THORACIC SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Waqas Ullah, Abdul-Rahman M. Suleiman, Heba Osman, Sairamya Bodempudi, Hamza Zahid Ullah Muhammadzai, Salman Zahid, Mohamed Zghouzi, Yasar Sattar, Salim S. Virani, David L. Fischman, M. Chadi Alraies
Summary: This study analyzed data from the Nationwide Readmissions Database and found that patients undergoing transcatheter aortic valve implantation (TAVI) for aortic insufficiency had higher rates of in-hospital clinical events, mortality, major bleeding, and valvular complications compared to those undergoing TAVI for aortic stenosis. However, there were no significant differences in these complications at 30-day and 180-day follow-up.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Medicine, General & Internal
Taishi Okuno, Caglayan Demirel, Daijiro Tomii, Gabor Erdoes, Dik Heg, Jonas Lanz, Fabien Praz, Rainer Zbinden, David Reineke, Lorenz Raber, Stefan Stortecky, Stephan Windecker, Thomas Pilgrim
Summary: This study aimed to evaluate the risk of noncardiac surgery after TAVI. The results suggest that noncardiac surgery can be performed early after successful TAVI, and device performance may impact the risk of adverse outcomes after surgery.
Article
Cardiac & Cardiovascular Systems
Yang Liu, Mengen Zhai, Yu Mao, Chennian Xu, Yanyan Ma, Lanlan Li, Ping Jin, Jian Yang
Summary: This study examines the early experience with transcatheter aortic valve replacement (TAVR) in patients with quadricuspid aortic valve (QAV). The results demonstrate that TAVR is a feasible treatment option for QAV patients with acceptable early outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hirokazu Onishi, Masaki Izumo, Toru Ouchi, Haruhito Yuki, Toru Naganuma, Tatsuya Nakao, Sunao Nakamura
Summary: This retrospective study examined the clinical effects of aortic valve replacement (AVR) in patients with moderate mixed aortic valve disease (MAVD). The study found that approximately half of the patients eventually required AVR and patients who underwent AVR had a significantly lower rate of the primary endpoint compared to those managed with medical treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sulayman el Mathari, Noor Boulidam, Frederiek de Heer, Laurent de Kerchove, Hans-Joachim Schaefers, Emmanuel Lansac, Jos W. R. Twisk, Jolanda Kluin
Summary: This study investigated the predictive value of aortic valve cusp retraction, calcification, and fenestration for the feasibility of aortic valvuloplasty. The results showed that all three factors were associated with an increased rate of switch to valve replacement, with calcification and retraction also being related to recurrence of severe aortic regurgitation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Adam R. Kowalowka, Wojciech Wanha, Marcin Malinowski, Paulina Kania-Olejnik, Marek A. Deja
Summary: This study aimed to determine truly moderate functional mitral regurgitation (FMR) and evaluate its impact on survival in patients undergoing aortic valve replacement (AVR). The presence of permanent moderate FMR significantly impacted 30-day and mid-term survival in patients undergoing AVR for aortic stenosis (AS).
KARDIOLOGIA POLSKA
(2023)
Review
Medicine, General & Internal
Jules Mesnier, Vassili Panagides, Jorge Nuche, Josep Rodes-Cabau
Summary: This article summarizes the current indications for transcatheter aortic valve replacement (TAVR) and explores future directions for its expansion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Daijiro Tomii, Taishi Okuno, Fabien Praz, Dik Heg, Mirjam Gauri Wild, Jonas Lanz, Stefan Stortecky, David Reineke, Stephan Windecker, Thomas Pilgrim
Summary: A significant proportion of patients were deemed potential candidates for TTVI after TAVR, with impaired prognosis and persistently impaired functional status at 1 year after the procedure.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, General & Internal
Shirit Kazum, Mordehay Vaturi, Idit Yedidya, Shmuel Schwartzenberg, Olga Morelli, Keren Skalsky, Hadas Ofek, Ram Sharony, Ran Kornowski, Yaron Shapira, Alon Shechter
Summary: Little is known about the natural history of non-significant mitral and tricuspid regurgitation (MR and TR) following surgical aortic valve replacement (SAVR) for aortic regurgitation (AR). This study retrospectively analyzed 184 patients who underwent SAVR for AR and found that about one fifth of patients developed significant MR/TR within six years, which correlated with worse cardiac condition and survival, and could be predicted by baseline clinical and echocardiographic variables.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Review
Medicine, General & Internal
Victor Quentin, Jules Mesnier, Clemence Delhomme, Neila Sayah, Paul Guedeney, Olivier Barthelemy, Gaspard Suc, Jean-Philippe Collet
Summary: Transcatheter mitral valve replacement (TMVR) is an emerging field dedicated to addressing the therapeutic challenges posed by patients at high surgical risk with mitral valve disease. TMVR can be categorized into TMVR with transcatheter aortic valves (TAV) and TMVR with dedicated devices. This field is gradually surmounting technical challenges and numerous devices are currently undergoing clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
William C. Roberts, Yusuf M. Salam
Summary: The study found that the majority of patients survived more than 1 year after undergoing mechanical prosthesis explantation, with most patients experiencing prosthetic infection. Thrombus formation and prosthetic infection were identified as the main causes of mechanical prosthetic valve damage.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marianna Buonocore, Pieter De Meester, Marius Brusselmans, Tim Van Puyvelde, Anton Verrijcken, Filip Rega, Tom Verbelen
Summary: The study aimed to assess the evolution of secondary tricuspid regurgitation (TR) after isolated aortic valve replacement (AVR) and its impact on mortality, as well as to identify possible predictors of persistent TR and TR de novo. The results showed that patients with TR >= 2 had worse long-term survival after AVR, especially in older age groups. Age was also a predictor of persistent TR after AVR. Some patients developed TR de novo after isolated AVR, but this did not affect survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Lindsay A. Edwards, Fei Feng, Mehreen Iqbal, Yong Fu, Amy Sanyahumbi, Shiying Hao, Doff B. McElhinney, X. Bruce Ling, Craig Sable, Jiajia Luo
Summary: In this study, a machine learning model was developed to identify mitral regurgitation (MR) on echocardiography. The model achieved high accuracy and F1 score in classifying the view and detecting MR. This is a promising step towards machine learning-based diagnosis of valvular heart disease in pediatric echocardiography.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Heather M. M. Giacone, Henry Chubb, Anne M. M. Dubin, Kara S. S. Motonaga, Scott R. R. Ceresnak, William R. R. Goodyer, Debra Hanisch, Anthony V. V. Trela, Nicole Boramanand, Erin Lencioni, Derek Boothroyd, Anna Graber-Naidich, Gail Wright, Christiane Haeffele, Seth A. A. Hollander, Doff B. B. McElhinney, Michael Ma, Frank L. L. Hanley, Sharon Chen
Summary: This study assessed the incidence of ventricular arrhythmias (VAs) in Fontan patients and their implications on transplant-free survival. The results showed that 11% of patients were diagnosed with VA, and VA was highly associated with the risk of transplant or death. Older age at Fontan and a history of right ventricular to pulmonary artery conduit were risk factors for VA. A diagnosis of VA in Fontan patients should lead to increased clinical surveillance.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew J. Gillespie, Doff B. Mcelhinney, Thomas K. Jones, Daniel S. Levi, Jeremy Asnes, Robert G. Gray, Allison K. Cabalka, Kazuto Fujimoto, Athar M. Qureshi, Henri Justino, Lisa Bergersen, Lee N. Benson, Daniel Haugan, Brian A. Boe, John P. Cheatham
Summary: The Harmony TPV device shows favorable clinical and hemodynamic outcomes in the treatment of pulmonary regurgitation.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Chemistry, Analytical
Ali Kight, Ileana Pirozzi, Xinyi Liang, Doff B. McElhinney, Amy Kyungwon Han, Seraina A. Dual, Mark Cutkosky
Summary: This study presents a modular approach to develop strain sensors for large deformations. The method separates the extension and signal transduction mechanisms using a soft, elastomeric transmission and a high-sensitivity microelectromechanical system (MEMS) transducer. The durability and performance of the sensor were evaluated through cyclic loading tests and modeling, supporting its potential application in human health monitoring.
Article
Biochemistry & Molecular Biology
Yaqi Zhang, Karl G. G. Sylvester, Bo Jin, Ronald J. J. Wong, James Schilling, C. James Chou, Zhi Han, Ruben Y. Y. Luo, Lu Tian, Subhashini Ladella, Lihong Mo, Ivana Maric, Yair J. J. Blumenfeld, Gary L. L. Darmstadt, Gary M. M. Shaw, David K. K. Stevenson, John C. C. Whitin, Harvey J. J. Cohen, Doff B. B. McElhinney, Xuefeng B. B. Ling
Summary: This study identified seven metabolomic biomarkers in urine samples collected from 60 pregnant women, using liquid chromatography mass spectrometry (LCMS/MS). A predictive model based on these biomarkers was developed using the XGBoost algorithm and showed good performance in identifying individuals at risk of developing preeclampsia.
Article
Cardiac & Cardiovascular Systems
Lisa Wise-Faberowski, Jin Long, Michael Ma, Helen R. R. Nadel, Jennifer Shek, Jeffrey A. A. Feinstein, Elisabeth Martin, Frank L. L. Hanley, Doff B. B. McElhinney
Summary: In patients with tetralogy of Fallot and major aortopulmonary collaterals (MAPCAs), the pulmonary blood supply is highly variable. Our study analyzed serial lung perfusion scintigraphy (LPS) and found that pulmonary flow distribution prior to discharge was balanced, and there was minimal change over time. However, there was considerable patient-to-patient variation in both metrics.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Zachary L. Steinberg, Allison K. Cabalka, David T. Balzer, Jeremy D. Asnes, Brian H. Morray, Matthew J. Gillespie, Doff B. Mcelhinney
Summary: In this study, we collected data on patients who underwent reintervention for TPV25 dysfunction and described findings related to distortion of the stent frame and tissue accumulation.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Brian H. Morray, Kevin F. Kennedy, Doff B. McElhinney
Summary: This study evaluated the usage patterns of covered stents for the treatment of coarctation of the aorta over a 5-year period. The results showed that adult patients were more likely to receive covered stent treatment, and the probability of adverse events during the treatment was low.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Doff B. Mcelhinney, Ritu Asija, Yulin Zhang, Ayush Jaggi, Jennifer Shek, Lynn F. Peng, Michael Ma, Elisabeth Martin, Frank L. Hanley
Summary: This study characterized a 20-year institutional experience managing patients with major aortopulmonary collateral arteries (MAPCAs) and found that outcomes for patients with pulmonary atresia or stenosis and MAPCAs have continued to improve.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carl L. Backer, David M. Overman, Joseph A. Dearani, Jennifer C. Romano, James S. Tweddell, S. Ram Kumar, Bradley S. Marino, Emile A. Bacha, Robert D. B. Jaquiss, Ali N. Zaidi, Michelle Gurvitz, John M. Costello, Trudy A. Pierick, William J. Ravekes, James A. Reagor, James D. St. Louis, James Spaeth, William T. Mahle, Andrew Y. Shin, Keila N. Lopez, Tara Karamlou, Karl F. Welke, Roosevelt Bryant, S. Adil Husain, Jonathan M. Chen, Aditya Kaza, Winfield J. Wells, Andrew C. Glatz, Mitchell I. Cohen, Doff B. Mcelhinney, David A. Parra, Sara K. Pasquali
Summary: Variations exist in care and outcomes for pediatric and congenital heart surgery in the United States. This collaborative effort aims to develop consensus recommendations across different disciplines and healthcare professionals to improve care delivery in US centers.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Christiane Haeffele, Doff B. Mcelhinney
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Ma, Kun Chen, Yun Ding, Xiao Li, Qiming Tang, Bo Jin, Ruben Y. Luo, Sheeno Thyparambil, Zhi Han, C. James Chou, Ashlee Zhou, James Schilling, Zhiguang Lin, Yan Ma, Qing Li, Mengxue Zhang, Karl G. Sylvester, Seema Nagpal, Doff B. McElhinney, Xuefeng B. Ling, Bobin Chen
Summary: This study developed two logistic regression models using metabolic markers in cerebrospinal fluid (CSF) for the diagnosis and differential diagnosis of PCNSL. These models provide valuable insights and hold promise for the future development of a non-invasive and reliable diagnostic tool for PCNSL.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Carl L. Backer, David M. Overman, Joseph A. Dearani, Jennifer C. Romano, James S. Tweddell, S. Ram Kumar, Bradley S. Marino, Emile A. Bacha, Robert D. B. Jaquiss, Ali N. Zaidi, Michelle Gurvitz, John M. Costello, Trudy A. Pierick, William J. Ravekes, James A. Reagor, James D. St. Louis, James Spaeth, William T. Mahle, Andrew Y. Shin, Keila N. Lopez, Tara Karamlou, Karl F. Welke, Roosevelt Bryant, S. Adil Husain, Jonathan M. Chen, Aditya Kaza, Winfield J. Wells, Andrew C. Glatz, Mitchell I. Cohen, Doff B. Mcelhinney, David A. Parra, Sara K. Pasquali
Summary: This article discusses the variation in care and outcomes for pediatric and congenital heart surgery patients in the United States. It highlights the lack of recent guidance and collaborative efforts in the field. The initiative aims to bring together professional societies and healthcare professionals to develop consensus recommendations for US centers. The focus is initially on pediatric heart surgery, with future efforts recommended to focus on the adult congenital population.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Correction
Oncology
Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G. Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian, Harvey J. Cohen, Doff B. Mcelhinney
BIOMARKER RESEARCH
(2023)
Letter
Oncology
Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G. Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian, Harvey J. Cohen, Doff B. Mcelhinney
Summary: This study aimed to evaluate the feasibility of using dried blood spot (DBS) for screening and classifying congenital heart disease (CHD). The study analyzed metabolites in DBS samples to identify metabolic abnormalities in CHD patients and discovered potential biomarkers for CHD assessment and subtype classification. The study demonstrated for the first time that it is feasible to validate metabolite profiling results using long-term stored DBS samples.
BIOMARKER RESEARCH
(2023)