Article
Biochemistry & Molecular Biology
Denisa Miklankova, Irena Markova, Martina Huttl, Iveta Zapletalova, Martin Poruba, Hana Malinska
Summary: Metformin can reduce cardiovascular risk independently of glycemic control, with non-glycemic benefits such as improved lipid and fatty acid metabolism and lower blood pressure. In a rat model, metformin treatment reduced accumulation of neutral lipids in the myocardium and showed associations with gene expression and enzyme activity. Additionally, metformin improved fatty acid composition in the heart muscle and had positive effects on arachidonic acid metabolism and related metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Edgars Liepinsh, Janis Kuka, Karlis Vilks, Baiba Svalbe, Gundega Stelfa, Reinis Vilskersts, Eduards Sevostjanovs, Niks Ricards Goldins, Valerija Groma, Solveiga Grinberga, Mario Plaas, Marina Makrecka-Kuka, Maija Dambrova
Summary: Deletion of the TMLHE gene in mice leads to reduced synthesis of long-chain acylcarnitines, resulting in decreased cardiac and mitochondrial damage, and a smaller infarct size. This study confirms that inhibiting the accumulation of ROS-increasing intermediates in fatty acid metabolism prevents damage during ischemia-reperfusion.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Rheumatology
Changjing Feng, Wangyan Liu, Xiaoxuan Sun, Qiang Wang, Xiaomei Zhu, Xiaoyue Zhou, Yi Xu, Yinsu Zhu
Summary: This study aimed to investigate characteristics of myocardial involvement and compare differences between patients with polymyositis (PM) and dermatomyositis (DM) by cardiac MR (CMR) imaging. The results showed that CMR tissue characterization imaging could detect early myocardial involvement in PM and DM patients without overt left ventricular dysfunction. Furthermore, the characteristics of myocardial involvement were different between PM and DM patients, with more serious involvement seen in PM patients.
Article
Immunology
Ming-min Zhou, Di-wen Li, Liao Xu, Bin Kong, Xi Wang, Yan-hong Tang, He Huang, Yu Liu
Summary: Propionate administration in early stage after myocardial infarction can alleviate cardiac dysfunction and remodeling by modulating macrophages polarization and pro-inflammatory cytokine production.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Francesca De Lio, Alessandro Andreis, Giulia De Lio, Matteo Bellettini, Stefano Pidello, Claudia Raineri, Guglielmo Gallone, Gianluca Alunni, Simone Frea, Massimo Imazio, Davide Castagno, Gaetano Maria De Ferrari
Summary: The identification of heart failure (HF) patients at risk for arrhythmic sudden cardiac arrest (SCA) is challenging. Implantable cardioverter defibrillator (ICD) is recommended to prevent SCA in HF patients with reduced left ventricular ejection fraction (LVEF), but the role of LVEF in predicting SCA has been debated. Advanced imaging techniques such as speckle tracking, cardiac magnetic resonance, nuclear imaging, and computed tomography have been developed to assess electrophysiological heterogeneity, fibrosis, sympathetic nervous system dysfunction, and myocardial scar for predicting SCA in HF patients. Modern artificial intelligence applications in cardiovascular imaging are also discussed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Attila Feher, Konrad Pieszko, Aakash Shanbhag, Mark Lemley, Bryan Bednarski, Robert J. H. Miller, Cathleen Huang, Leonidas Miras, Yi-Hwa Liu, Albert J. Sinusas, Piotr J. Slomka, Edward J. Miller
Summary: This study compared the predictive value of CT attenuation-corrected stress total perfusion deficit (AC-sTPD) and non-corrected stress TPD (NC-sTPD) in obese patients undergoing SPECT myocardial perfusion imaging (MPI). The results showed that AC-sTPD outperformed NC-sTPD in predicting major adverse cardiac events (MACE) in patients with a body mass index (BMI) greater than or equal to 35kg/m^2, highlighting the importance of CT attenuation correction.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Shobi Sivathamboo, Zining Liu, Fiona Sutherland, Erica Minato, Pablo Casillas-Espinosa, Nigel C. Jones, Marian Todaro, Udaya Seneviratne, Varduhi Cahill, Raju Yerra, Christopher French, John-Paul Nicolo, Piero Perucca, Patrick Kwan, Paul Sparks, Terence J. O'Brien
Summary: This study utilized implantable cardiac monitors to detect cardiac arrhythmias in patients with chronic drug-resistant epilepsy, revealing a high incidence of clinically significant arrhythmias. These findings may impact the risk of premature mortality, including SUDEP, in these patients.
Article
Urology & Nephrology
Magdalene M. Assimon, Patrick H. Pun, Lily Wang, Sana M. Al-Khatib, M. Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, Jennifer E. Flythe
Summary: This study conducted two cohort studies using the United States Renal Data System to compare the cardiac safety of azithromycin with amoxicillin-based antibiotics and levofloxacin in the hemodialysis population. The results showed that azithromycin treatment was associated with a higher risk of sudden cardiac death compared to amoxicillin-based antibiotics, but a lower risk compared to levofloxacin.
KIDNEY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Chen-xu Zhao, Lai Wei, Jian-xun Dong, Jie He, Ling-cong Kong, Song Ding, Heng Ge, Jun Pu
Summary: This study constructed diagnostic nomograms for predicting cardiac injuries in patients with STEMI and found that these nomograms have good effectiveness in predicting cardiac injuries after STEMI, providing a new option for individual risk stratification for physicians.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ping-Hsun Wu, Rie Io Glerup, My Hanna Sofia Svensson, Niclas Eriksson, Jeppe Hagstrup Christensen, Philip de Laval, Inga Soveri, Magnus Westerlund, Torbjorn Linde, Osten Ljunggren, Bengt Fellstrom
Summary: This study found that IL-8, TIM-1, and CCL20 can predict the outcomes of death and cardiovascular diseases in hemodialysis patients. Additionally, SCF and GAL are associated with a decreased risk of all-cause death and cardiovascular death.
Article
Nutrition & Dietetics
Meng Yuan, Yue Zhang, Tong Hua, Xiang-Li Liu, Tong Liu, Ru-Yu Yuan, Guang-Ping Li, Yi Zhu, Xu Zhang
Summary: The study suggests that Omega-3 polyunsaturated fatty acid (omega-3 PUFA) supplementation may improve lipid metabolism and endothelial function by affecting eicosanoid metabolic status during convalescent healing after acute myocardial infarction.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
S. Neil Holby, Tadarro Lee Richardson Jr, J. Lukas Laws, Thomas A. McLaren, Jonathan H. Soslow, Michael T. Baker, Jeffrey M. Dendy, Daniel E. Clark, Sean G. Hughes
Summary: Infection with SARS-CoV-2, the virus that causes COVID, can lead to various cardiovascular complications. Cardiac imaging has become crucial in differentiating pulmonary and cardiovascular complications due to the non-specific symptoms and laboratory findings of COVID patients. This review summarizes the existing literature and major societal guidelines to provide an overview of the indications and utility of different cardiac imaging modalities for diagnosing cardiovascular complications of COVID.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yu-Hsuan Li, Min-Huan Wu, Wen-Jane Lee, I-Te Lee
Summary: This study found that there is a synergistic effect between high plasma DKK-1 levels and obstructive CAD in predicting MACEs in patients with angina.
Article
Cell Biology
Peng Wang, Fan Zhang, Liming Pan, Yunke Tan, Fengqing Song, Qiulin Ge, Zitong Huang, Lan Yao
Summary: Inhibiting cardiac mitochondrial FAO after ROSC can reduce excessive cardiac ROS generation and preserve myocardial function, likely by improving cardiac mitochondrial metabolism dysfunction in a rat model of cardiac arrest.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medical Laboratory Technology
David Collister, Andrea Mazzetti, Anuja Bhalerao, Jessica Tyrwhitt, Peter Kavsak, Kenneth S. Brimble, P. J. Devereaux, Michael Walsh
Summary: The concentrations of high sensitivity troponin I, galectin-3, and heart-type fatty acid binding protein show significant changes during hemodialysis, with ultrafiltration volume and hemodialysis treatment time influencing their levels.
CLINICAL CHEMISTRY
(2021)