期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 29, 页码 10202-10205出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja504458j
关键词
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资金
- 973 program [2011CB808700]
- NSFC [21225210, 21202185, 21121062]
- STCSM [11JC1415000]
- CAS/SAFEA International Partnership Program for Creative Research Teams
A novel copper-catalyzed intermolecular trifluoromethylarylation of alkenes is developed using less active ether-type Togni's reagent under mild reaction conditions. Various alkenes and diverse arylboronic acids are compatible with these conditions. Preliminary mechanistic studies reveal that a mutual activation process between arylboronic acid and CF3+ reagent is essential. In addition, the reaction might involve a rate-determining transmetalation, and the final aryl C-C bond is derived from reductive elimination of the aryl(alkyl)Cu(III) intermediate.
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