期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 50, 页码 17382-17385出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja509892u
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资金
- ETH Zurich [ETH-18 09-1]
Epoxyisoprostanes EI (1) and EC (2) are effective inhibitors of the secretion of proinflammatory cytokines IL-6 and IL-12. In detailed studies toward the investigation of the molecular mode of action of these structures, a highly potent lactone (3) derived from 1 was identified. The known isoprostanoids 1 and 2 are most likely precursors of 3, the product of facile intramolecular reaction between the epoxide with the carboxylic acid in 2.
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