期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 10, 页码 3728-3731出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja412256f
关键词
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资金
- NSERC
- CIHR
The concept of site-specific integration of fragments into macrocyclic entities has not yet found application in the realm of synthetic chemistry. Here we show that the reduced amidicity of aziridine amide bonds provides an entry point for the site-specific integration of amino acids and peptide fragments into the homodetic cyclic peptide architecture. This new synthetic operation improves both the convergence and divergence of cyclic peptide synthesis.
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