Article
Chemistry, Multidisciplinary
Dilanka V. D. Walpita Kankanamalage, Jennifer H. T. Tran, Noah Beltrami, Kun Meng, Xiao Zhou, Pravin Pathak, Lyle Isaacs, Alexander L. Burin, Mehnaaz F. Ali, Janarthanan Jayawickramarajah
Summary: This study introduces a synthetic surrogate called host-guest-driven toehold-mediated strand displacement (HG-TMSD) that utilizes bioorthogonal interactions to control the process of DNA strand displacement. The HG-TMSD method can be finely modulated by changing the structure of the input sequence and can also be regulated by competing small-molecule guests. It can be integrated into functional devices for controlling enzyme activity and detecting specific microRNA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Ning Bu, Wen-Yuan Wu, Peng Jiang, Zi-Yuan Zhan, Jin-Long Wan, Zi-Jing Wu, Rong Wan
Summary: A novel complex [(Fe4L4)-L-II](8+) was designed and synthesized through subcomponent self-assembly, with a tetrahedral cage structure confirmed by H-1 NMR and ESI-MS measurements. The weak intermolecular interactions with guest molecules may be attributed to the steric effect of methyl groups near the peripheral apertures of the cage.
Article
Chemistry, Multidisciplinary
Rebecca L. Spicer, Helen M. O'Connor, Yael Ben-Tal, Hang Zhou, Patrick J. Boaler, Fraser C. Milne, Euan K. Brechin, Guy. C. Lloyd-Jones, Paul J. Lusby
Summary: Coordination cage catalysis is a strategy that utilizes a cage as an exogenous catalyst, rather than relying on the endogenous binding of substrates. The cage alters the properties of a cofactor guest, which then transfers reactivity to the bulk-phase to catalyze reactions.
Article
Chemistry, Multidisciplinary
Hector Fernandez-Caro, Alejandro Mendez-Ardoy, Javier Montenegro
Summary: The intracellular reconfiguration of nanoparticles by a host/guest mechanism with biocompatible oligomeric competitors has been achieved, allowing for the direct exchange of pendants at the surface of nanoparticles and the intracellular dynamic chemical reconfiguration of biocompatible colloidal systems.
Article
Chemistry, Inorganic & Nuclear
Miao Li, Yu-Qi Shi, Xinye Gan, Longbin Su, Jialin Liang, Huiqi Wu, Yiting You, Meizi Che, Peiyang Su, Tun Wu, Zhe Zhang, Wei Zhang, Liao-Yuan Yao, Pingshan Wang, Ting-Zheng Xie
Summary: A new type of coordination-driven host combining porphyrin and terpyridine moieties with a long cavity was designed and synthesized in this study. The host can encapsulate bisite or monosite guests through axial coordination binding of porphyrin and aromatic pi interactions of terpyridine. Characterization of the ligands and prismatic complexes was conducted using ESI-MS, TWIM-MS, NMR spectrometry, and single-crystal X-ray diffraction analysis. The encapsulation mechanism of guests was investigated through ESI-MS, NMR spectrometry, and transient absorption spectroscopy analysis. The binding constant and stability were determined by UV-Vis spectrometry and gMS2 techniques. A selectively confined condensation reaction was performed and detected by NMR spectrometry based on the prism. This study provides a new type of host that could be used for the detection of pyridyl- and amine-contained molecules and confined catalysis.
INORGANIC CHEMISTRY
(2023)
Review
Agriculture, Multidisciplinary
Wenjie Li, Weiwei Xu, Siyun Zhang, Jia Li, Juan Zhou, Demei Tian, Jing Cheng, Haibing Li
Summary: Significant progress has been made in the research on drug encapsulation and release based on supramolecular macrocycles, laying a solid foundation for the development of novel nanopesticide preparations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Organic
Sudhakar Ganta, Jan-Hendrik Borter, Christoph Drechsler, Julian J. Holstein, Dirk Schwarzer, Guido H. Clever
Summary: A [Pd2L4] coordination cage, consisting of electron-rich phenothiazine-based ligands and encapsulating an electron-deficient anthraquinone-based disulfonate guest, has been reported. Transient absorption spectroscopy reveals photoinduced electron transfer from the host's chromophores to the guest, as indicated by characteristic spectral features. The host-guest complex was characterized using various techniques, and spectroelectrochemical experiments and DFT calculations support the proposed light-induced charge separation.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Meiling Li, Guojian Ren, Weiting Yang, Yu Fang, Xuanming Zhang, Yu Ma, Shuyan Song, Qinhe Pan
Summary: Researchers have developed a Cd-based MOF as a host to encapsulate both lanthanide ions and carbon quantum dots to achieve multiple fluorescence emissions through modulation of host-guest and guest-guest interactions, showing promise for various anticounterfeiting applications.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Meiling Li, Guojian Ren, Weiting Yang, Yu Fang, Xuanming Zhang, Yu Ma, Shuyan Song, Qinhe Pan
Summary: Developing fluorescent materials with multiple and tunable emissions in MOFs can achieve different modes of fluorescence emission for multiple anticounterfeiting purposes. This research provides a new approach for constructing hybrid MOF-based materials with controlled fluorescence properties for emerging anticounterfeiting applications in various fields.
INORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Yu-Liang Lin, Sheng Zheng, Chia-Wei Chang, Min-Jie Lee, Yi-Fan Chen, Jiun-Tai Chen
Summary: In this study, versatile and on-demand photocontrollable ionic conductive nanocomposite hydrogels were successfully synthesized via host-guest chemistry. The hydrogels showed higher conductivity under visible light irradiation and lower conductivity under UV irradiation, which could be further manipulated by adjusting the surface-area-to-volume ratio of the nanopores and the alkyl chain length of the anions.
Article
Chemistry, Multidisciplinary
Laurent Severy, Jacek Szczerbinski, Mert Taskin, Isik Tuncay, Fernanda Brandalise Nunes, Chiara Cignarella, Gabriele Tocci, Olivier Blacque, Jurg Osterwalder, Renato Zenobi, Marcella Iannuzzi, S. David Tilley
Summary: The study demonstrates a non-covalent 'click' chemistry approach to reversibly bind molecular electrocatalysts to electrode surfaces through host-guest complexation. This efficient method enables the replacement and reuse of molecular catalysts, enhancing the attractiveness of electrosynthetic systems.
Review
Chemistry, Multidisciplinary
Yinlin Chen, Wanpeng Lu, Martin Schroder, Sihai Yang
Summary: Metal-organic frameworks (MOFs) are hybrid porous materials with high crystallinity, extensive surface area, and adjustable pore sizes. They have various applications in gas adsorption, separation, and catalysis. The design flexibility of organic ligands and precise engineering of uniform pore environments in MOFs enable rich interactions between the material and adsorbed gas molecules, which greatly impact the overall performance.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Ahmed Shaukat, Eduardo Anaya-Plaza, Ngong Kodiah Beyeh, Mauri A. Kostiainen
Summary: The study demonstrates the electrostatic binding between cationic pillar[5]arenes and (apo)ferritin cages to form porous structures with potential applications in water-remediation technologies.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Xi Yang, Di Yuan, Jinhong Hou, Adam C. Sedgwick, Suying Xu, Tony D. James, Leyu Wang
Summary: The field of supramolecular chemistry has rapidly expanded and become highly influential in various areas like biomedicine, energy materials, catalysis, and sensing. The combination of host/guest chemistry with functional inorganic nanoparticles has led to many new applications in drug delivery, bioimaging, and sensing. Recent progress in the development of organic/inorganic supramolecular nano-systems incorporating host/guest chemistry has been summarized, highlighting their applications in drug delivery, biological imaging, and sensing.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Zhifeng Xiao, Hannah F. Drake, Yohannes H. Rezenom, Peiyu Cai, Hong-Cai Zhou
Summary: The study demonstrates the structural flexibility and stimulus-responsive features of zirconocene-based PCCs. Two interconvertible PCCs, PCC-20c and PCC-20t, are constructed from the same cluster and ligand but exhibit different shapes and properties. The conversion from PCC-20t into PCC-20c is found to be an entropically driven process influenced by solvent environment, counter anions, and light irradiation.
Article
Chemistry, Multidisciplinary
Koki Ikemoto, Shotaro Harada, Seungmin Yang, Taisuke Matsuno, Hiroyuki Isobe
Summary: A 3-nm molecule with a cylindrical core and cross-shaped rims was designed and synthesized using a modular synthetic route. Carbazole units were incorporated at the rims and two types of nitrogen atoms were doped into the defective cylinder, leading to solvatochromic shifts in fluorescence. Crystallographic analyses of the large molecule revealed a unique helical arrangement of nitrogen-doped cylinders in the crystal.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Narito Ozawa, Kilingaru Shivakumar, Muthuchamy Murugavel, Yuya Inaba, Tomoki Yoneda, Yuki Ide, Jenny Pirillo, Yuh Hijikata, Yasuhide Inokuma
Summary: Cyclic oligoketones composed of 3,3-dimethylpentane-2,4-diones exhibit crown ether-like alkali metal ion binding behavior and can be utilized for catalysis in the Finkelstein reaction. Additionally, novel ion-binding hosts can be generated by terminal functionalization of linear polyketones.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jiazhuo Chen, Takashi Kikuchi, Kazuhiro Takagi, Hiromasa Kiyota, Kiyohiro Adachi, Takaaki Mitsuhashi, Makoto Fujita
Summary: This article introduces a method for analyzing the degradation products of organic pollutants, which can obtain the crystal structure of organic pollutants. The study found that halogen interactions play an important role in molecular recognition in the crystalline sponge.
Article
Chemistry, Multidisciplinary
Yoshimasa Taniguchi, Takashi Kikuchi, Sota Sato, Makoto Fujita
Summary: Most transformation products of trans-iso-alpha-acid, isolated in small quantities by HPLC, were structurally analyzed using the crystalline sponge method. Thirteen compounds, including eight previously unreported, were successfully isolated and analyzed with their absolute configuration assigned, providing an improved understanding of chemical transformations during beer aging.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yuya Inaba, Yu Kakibayashi, Yuki Ide, Jenny Pirillo, Yuh Hijikata, Tomoki Yoneda, Yasuhide Inokuma
Summary: The synthesis of different types of macrocyclic compounds revealed the scope and mechanism of the ring expansion reaction. The strain of the ring was found to increase with the number of inner NH sites. N-methylation of certain compounds induced a ring expansion reaction, leading to the isolation of a linear reaction intermediate.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Taisuke Matsuno, Kanato Takahashi, Koki Ikemoto, Hiroyuki Isobe
Summary: A bowl-in-tube complex was formed by encapsulating a halogenated bowl-shaped guest, corannulene, into a cylindrical host, [4]cyclochrysenylene, which imitated supramolecular complexes between bowl guests and carbon nanotubes. The stoichiometry and molecular structures of the complexes were revealed through careful statistical analysis and X-ray crystallography. The cooperativity of the association in solution varied depending on the guest, with fluorinated corannulene showing negative cooperativity and larger halogenated corannulene showing positive cooperativity.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Multidisciplinary Sciences
Toshiya M. Fukunaga, Takahide Kato, Koki Ikemoto, Hiroyuki Isobe
Summary: The study reports the synthesis and optical resolution of a minimal cage structure of a chiral diamond-twin network, which is assembled with triangular phenine units at 14 vertices forming 15 biaryl edges. The unique chirality of the network revealed by the minimal cage may stimulate explorations of chiral carbonaceous materials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Hiroki Takezawa, Yuya Fujii, Takashi Murase, Makoto Fujita
Summary: This article investigates the regioselective spirocyclization of a 2-biphenylacetylene in a specific conformation within a confined cavity, and discovers the selective 5-endo-dig cyclization in contrast to the normally occurring 6-endo-dig cyclization in common organic media.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Inorganic & Nuclear
Yuya Domoto, Makoto Fujita
Summary: The coordinative self-assembly of simple building blocks towards complex nanostructures is currently a popular research area in the development of artificial nanomaterials comparable to biological systems. Traditional coordination donors have been widely used in previous studies, but the recent emergence of weak pi-coordination between metal ions and unsaturated carbon-carbon bonds offers a flexible and highly tolerant bonding approach for complex nanoarchitectures. The combination of metal-acetylene pi-coordination with conventional coordination has allowed for the formation of large polyhedral complexes with unprecedented molecular entanglement, highlighting the potential advantages of this concept.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Keita Watanabe, Ranajit Saha, Yuya Inaba, Yumehiro Manabe, Tomoki Yoneda, Yuki Ide, Yuh Hijikata, Yasuhide Inokuma
Summary: Calix[3]-type macrocycles, including their furan derivatives, exhibit bathochromically shifted absorption spectra compared to their calix[4] and calix[6] analogues, and also show fluorescence emission. The degree of Stokes shift in the furan/pyrrole hybrid macrocycles varies depending on the solvent polarity. Non-covalent interaction analyses reveal enhanced interactions between neighboring aromatic rings in the calix[3]pyrrole macrocycle.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2023)
Article
Chemistry, Multidisciplinary
Taichi Sano, Yuhua Sun, Taichi Mukai, Yuya Inaba, Tomoki Yoneda, Yuki Ide, Jenny Pirillo, Yuh Hijikata, Yasuhide Inokuma
Summary: Recent progress in synthesizing calix[3]pyrrole suggests that cyclic polyketones with 3,3-dialkylated pentane-2,4-diones as repeating units show promise as precursors for strained calix-type macrocycles. In this study, we report the synthesis of a cyclic dimer of 3,3-dimethylpentane-2,4-dione and its furanophane derivative as potential precursors for calix[2]pyrrole and calix[2]furan, which are highly strained congeners. However, the formation of Paal-Knorr-type pyrrole or furan rings did not proceed under standard conditions used for calix[3]pyrrole or calix[3]furan due to the highly uphill process and activation energy involved in the second aromatic ring formation on the cyclic tetraketone.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2023)
Article
Polymer Science
Therese Eriksson, Harish Gudla, Yumehiro Manabe, Tomoki Yoneda, Daniel Friesen, Chao Zhang, Yasuhide Inokuma, Daniel Brandell, Jonas Mindemark
Summary: This study compares the properties of solid polymer electrolytes (SPEs) of three different carbonyl-containing polymers. Experimental measurements and molecular dynamics simulations reveal the influence of the polymer structure on ion transport and the possibility of achieving desired transport properties by fine-tuning the polymer chemistry.
Article
Chemistry, Multidisciplinary
Yuya Inaba, Jian Yang, Yu Kakibayashi, Tomoki Yoneda, Yuki Ide, Yuh Hijikata, Jenny Pirillo, Ranajit Saha, Jonathan L. Sessler, Yasuhide Inokuma
Summary: In this study, a calixpyrrole-based chiral macrocyclic system, calix[1]furan[1]pyrrole[1]thiophene (1), was synthesized from an oligoketone. The macrocycle adopts a partial cone conformation and undergoes racemization via ring inversion. N-methylation of the pyrrole moiety suppresses racemization and enables chiral resolution. Furthermore, this system can also serve as a precursor to yield various calix[n]furan[n]pyrrole[n]thiophene products (n = 2-4), including the largest calix[n]pyrrole-like species to be structurally characterized.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Chemical
Yuki Ide, Hayato Shirakura, Taichi Sano, Muthuchamy Murugavel, Yuya Inaba, Sheng Hu, Ichigaku Takigawa, Yasuhide Inokuma
Summary: This study reports a image-based machine learning (ML) method for predicting component ratio in mixtures. The method is applicable to various solid mixtures and has demonstrated accuracy in analysis.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yuya Domoto, Kidai Yamamoto, Shumpei Horie, Zhengsu Yu, Makoto Fujita
Summary: This study demonstrates the superb control of helical chirality of discrete polyhedra created from self-assembly of propeller-shaped ligands equipped with chiral side chains. The amplification of weak chiral inductions of each ligand unit is an efficient way to control the chirality of large discrete nanostructures with high structural complexity.
