A Concise Colorimetric and Fluorimetric Probe for Sarin Related Threats Designed via the Covalent-Assembly Approach

A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The covalent-assembly probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier-Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.