期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 32, 页码 11296-11299出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja506694v
关键词
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资金
- Aarhus University
- Carlsberg Foundation
- FNU
- CNPq/CsF
The first catalytic enantio- and diastereoselective synthesis of 4-nitropyrazolidines is presented. Asymmetric hydrogen-bonding activation of nitro-olefins facilitated the 1,3-dipolar cycloaddition with hydrazones, affording optically active 4-nitropyrazolidines containing three continuous stereogenic centers as a single diastereomer in up to 99% ee. Furthermore, it is demonstrated that the optically active 4-nitropyrazolidines can be applied as precursors for the synthesis of highly interesting 1,2,3-triamines.
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