☆ 4.8 Article

Diarylation of Alkenes by a Cu-Catalyzed Migratory Insertion/Cross-Coupling Cascade

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

卷 136, 期 42, 页码 14730-14733

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ja509056j

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Chemistry, Multidisciplinary

资金

Indiana University
ACS PRF
Indiana University Chester Davis Fellowship

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A strategy for the catalytic diarylation of alkenes is presented. The method involves the migratory insertion of alkenes into an Ar-Cu complex to generate a new C(sp(3))-Cu complex, which subsequently undergoes reaction with an aryl iodide to constitute a vicinal diarylation of an alkene. The method provides access to benzofuran- and indoline-containing products. Furthermore, highly diastereoselective examples are presented, allowing access to complex, stereochemically rich structures from simple alkene starting materials.

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