期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 26, 页码 9620-9623出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4044196
关键词
-
资金
- F. Hoffinann-La Roche Ltd
- Swiss State Secretariat for Education, Research and Innovation [C10.0116, CM0804]
- Marie Curie International Incoming Fellowship [331631]
A thiol-alkynylation procedure utilizing the hypervalent iodine alkyne transfer reagent TIPS-ethynyl-benziodoxolone has been developed. This scalable reaction proceeds in five minutes at room temperature in an open flask using commercially available reagents. The scope of the reaction is broad, with a variety of phenolic, benzylic, heterocyclic, and aliphatic thiols undergoing alkynylation in excellent yield. The method is highly chemoselective as a vast array of functional groups are tolerated. The utility of the thiol-alkynylation in postsynthetic elaboration has been demonstrated through the facile installment of a fluorophore tag on a cysteine-containing peptide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据