期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 37, 页码 13620-13623出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja405196f
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资金
- Philips Healthcare/Radiological Society of North America Research Seed grant [RSD1104]
- National Institute of Health [1DP2OD007246-01, 1R21CA152627]
- Morris Animal Foundation [D09CA-083]
- UIUC from the NIH National Cancer Institute Alliance for Nanotechnology in Cancer Midwest Cancer Nanotechnology Training Center [R25 CA154015A]
Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanopartides exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.
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