期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 2, 页码 550-553出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja310056y
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资金
- Centre National de la Recherche Scientifique
- Universite de Bourgogne
- Conseil Regional de Bourgogne
- Agence Nationale de la Recherche [ANR-10-JCJC-0709, PARI-SSTIC 6 (92-01)]
- Agence Nationale de la Recherche (ANR) [ANR-10-JCJC-0709] Funding Source: Agence Nationale de la Recherche (ANR)
An unprecedented strategy to control the quadruplex- vs duplex-DNA selectivity of a ligand is reported. We designed a compound whose structure can rearrange when it interacts with a G-quadruplex, thereby controlling its affinity. Thus, the first smart G-quadruplex ligand is reported, since this ligand experiences a structural change in the presence of quadruplexes but not in the presence of duplexes, ensuring a high level of quadruplex selectivity.
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