期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 7, 页码 2489-2492出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4002635
关键词
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资金
- NIH [CA106150]
The iso-migrastatin (iso-MGS) biosynthetic gene cluster from Streptomyces platensis NRRL 18993 consists of 11 genes, featuring an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes MgsIJK Systematic inactivation of mgsIJK in S. platensis enabled us to (i) identify two nascent products of the iso-MGS AT-less type I PKS, establishing an unprecedented novel feature for AT-less type I PKSs, and (ii) account for the formation of all known post-PKS biosynthetic intermediates generated by the three tailoring enzymes MgsIJK, which possessed significant substrate promiscuities.
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