期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 3, 页码 1454-1457出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja210496n
关键词
-
资金
- BBSRC [REI BB/D524516/1]
- Novozymes
- BP
- EPSRC
- Wellcome Trust
- Wolfson Foundation
- ERC [247450]
- Royal Society
Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to translate certain aspects of the organismal energy state into global zinc signals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据