Article
Multidisciplinary Sciences
Kou Li, Teppei Araki, Ryogo Utaki, Yu Tokumoto, Meiling Sun, Satsuki Yasui, Naoko Kurihira, Yuko Kasai, Daichi Suzuki, Ruben Marteijn, Jaap M. J. den Toonder, Tsuyoshi Sekitani, Yukio Kawano
Summary: This research designs a stretchable photo-sensor patch sheet for on-site dynamic chemical monitoring. The device can monitor the concentration of arbitrary water-soluble chemicals in liquids flowing inside soft tubes and has shape-conformable attachments and durability.
Article
Neurosciences
Hermundur Sigmundsson, Helga S. Thorsdottir, Herdis R. Njalsdottir, Svava Th Hjaltalin
Summary: This article aims to present an important perspective on reading skill development, based on the phonics approach and learning theories. The theories of Ericsson and Csikszentmihalyi are discussed, and the perspective is validated through survey results from a school in Iceland.
Review
Biochemistry & Molecular Biology
Mingdi Jiang, Aritra Nath Chattopadhyay, Vincent M. Rotello
Summary: Synthetic chemicals are widely used in various fields, and it is important to assess their safety. Cell-based genomic screening provides a non-invasive method to evaluate the effects of chemicals on cells and is more sensitive than traditional cell viability assessments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Telecommunications
Wiparat Busyatras, Chanon Warisarn, Santi Koonkarnkhai, Piya Kovintavewat
Summary: This study proposes a coding scheme for Bit-Patterned Magnetic Recording systems to effectively mitigate the negative impact of extreme Inter-Track Interference on system performance.
DIGITAL COMMUNICATIONS AND NETWORKS
(2021)
Article
Engineering, Electrical & Electronic
Golezar Gilanizadehdizaj, Kean C. Aw, Jonathan Stringer, Debes Bhattacharyya
Summary: Electronic skins, with flexible pressure sensors as an essential component, have attracted significant interest due to their broad applications in daily lives. This study reports on the fabrication of flexible piezo-resistive pressure sensor arrays using reduced graphene oxide on flexible PCB, demonstrating excellent mechanical stability, high sensitivity, and a wide working range of pressure. The research findings provide important technological foundations for achieving high-performance electronic skins.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Electrochemistry
Nguyen Quoc Dung, Tran Thi Thuy Duong, Tran Dai Lam, Dang Duc Dung, Nguyen Nhat Huy, Dang Van Thanh
Summary: In this study, a model of glucose reaction at the electrode was introduced and the reduction potential of the CuOOH/CuO redox couple at CuO nanowires/ITO electrode was determined via an empirical study. The cyclic voltage scanning of CNIE to glucose in different concentrations of NaOH electrolyte solution was conducted, and the standard electrode potential of the CuOOH/CuO redox couple was calculated based on the curve of glucose concentration versus oxidation potential in different pH media.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Tanaji M. Nimbalkar, Yogesh M. Jadhav, Reshma N. Dhanawade, Nanasaheb S. Pawar, Avinash C. Molane, Shivani S. Gavande, Ganesh T. Chavan, Chan-Wook Jeon, Shrikrishna D. Sartale, Vikas B. Patil
Summary: CeO2 nanoparticles were synthesized using a simple chemical method without surfactants or additives at low temperature and short reaction time. The effect of annealing temperatures on the structural, morphological, and chemiresistive properties of the CeO2 nanoparticles was investigated. The CeO2 nanoparticles exhibited a cubic crystal structure and porous morphology, with a specific surface area of 52.92 m2/g. The optimized operating temperature was found to be 150 degrees C, showing excellent response and stability towards NO2 gas.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Multidisciplinary Sciences
Zhong Guo, Oleh Smutok, Wayne A. Johnston, Patricia Walden, Jacobus P. J. Ungerer, Thomas S. Peat, Janet Newman, Jake Parker, Tom Nebl, Caryn Hepburn, Artem Melman, Richard J. Suderman, Evgeny Katz, Kirill Alexandrov
Summary: The study aims to investigate the optimal strategy for developing artificial small molecule:protein complexes that function as chemically induced dimerization (CID) systems. By using methotrexate-controlled CID systems, the critical role of drug-induced conformational change in ligand-controlled protein complex assembly is revealed. The utility of the developed CID is demonstrated by constructing an electrochemical biosensor of methotrexate for quantification in human serum, as well as developing a multiplexed bioelectronic system for repeated measurements of multiple analytes using methotrexate and functionally related biosensor of rapamycin.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna W. Kliza, Qiang Liu, Laura W. M. Roosenboom, Pascal W. T. C. Jansen, Dmitri Filippov, Michiel Vermeulen
Summary: This study utilized ADPr probes and mass spectrometry to identify MAR and PAR readers that play important roles in genome maintenance and immunity regulation. The findings highlight the diverse yet common functions of MAR and PAR readers in processes such as DNA damage response, cellular metabolism, RNA trafficking, and transcription. Additionally, the study reveals connections between ubiquitin signaling and ADP-ribosylation through monitoring PAR interactions upon induction of oxidative DNA damage.
Article
Chemistry, Analytical
Jingbo Zhang, Quancheng Chen, Xuemin Gao, Qian Lin, Ziqin Suo, Di Wu, Xijie Wu, Qing Chen
Summary: In this study, a label-free and antibody-free impedimetric biosensor based on molecularly imprinting technology was developed for quantifying exosomes derived from non-small-cell lung cancer (NSCLC) cells. The sensor showed high sensitivity and selectivity with an LOD of 2.03 x 10(3) and an LOQ of 4.10 x 10(4) particles/mL. It demonstrated great accuracy, precision, and retention of performance after multiple cycles of elution and re-adsorption. The sensor has potential clinical translational applications in improving the prognosis and survival of NSCLC patients.
Article
Chemistry, Multidisciplinary
Yihao Li, Junyu Long, Yun Chen, Yan Huang, Ni Zhao
Summary: The authors present a high-resolution flexible pressure sensor array fabricated through a two-step laser manufacturing process, which minimizes crosstalk interferences. The new design reduces the crosstalk coefficient and is particularly beneficial for pressure sensing on soft surfaces. Applications in tactile pattern recognition and minimally-invasive cancer surgery are demonstrated.
ADVANCED MATERIALS
(2022)
Review
Polymer Science
Ky Van Nguyen, Donggeun Lee, Youngnan Kim, Wi Hyoung Lee
Summary: This paper presents the application of fiber-type electronics in wearable electronic devices, focusing on the utilization of conjugated polymer fibers in field-effect and electrochemical transistors, as well as their wide range of applications in chemical and physical sensors.
Review
Polymer Science
Shunsuke Tomita
Summary: This review introduces a biosensing strategy called the chemical tongue, which mimics the human taste system by using polymeric materials and statistical techniques to recognize various complex biological samples in a unique manner.
Article
Biophysics
Li-Li Huang, Zi Qing Chua, Krzysztof Buchowiecki, Chamarthi Maheswar Raju, Pawel L. Urban
Summary: Conventional sensing methods only provide information on concentrations of analytes in a single point or in an averaged value. However, substances distributed on surfaces of sampled objects often exhibit complex inhomogeneities. In this study, enzyme-loaded hydrogel arrays were developed to obtain snapshots of chemical distributions on surfaces. The method has been optimized for glucose and lactic acid mapping and tested on fruit/vegetable cross-sections and cheese.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Yiran Guo, Peng Chen, Zhaolong Gao, Yiwei Li, Shunji Li, Xiaojun Feng, Bi-Feng Liu
Summary: In this paper, a time-coded multi-concentration microfluidic chemical waveform generator was developed for studying the dynamic cellular response to the complex extracellular microenvironment. The system offers high temporal resolution, high throughput, and multi-concentration combination stimulation, enabling accurate analysis of receptor conformation changes and signaling events in cells.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Natalia Milosevich, Fraser Hof
Article
Chemistry, Multidisciplinary
Meagan A. Beatty, Jorge Borges-Gonzalez, Nicholas J. Sinclair, Aidan T. Pye, Fraser Hof
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Medicinal
Chakravarthi Simhadri, Kevin D. Daze, Sarah F. Douglas, Natalia Milosevich, Leticia Monjas, Amarjot Dev, Tyler M. Brown, Anna K. H. Hirsch, Jeremy E. Wulff, Fraser Hof
Article
Chemistry, Medicinal
Derek J. Blevins, Ronan Hanley, Trevor Bolduc, David A. Powell, Michael Gignac, Kayleigh Walker, Mark D. Carr, Fraser Hof, Jeremy E. Wulff
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Multidisciplinary
Meagan A. Beatty, Allison J. Selinger, YuQi Li, Fraser Hof
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Sijie Wang, Kyle E. Denton, Kathryn F. Hobbs, Tyler Weaver, James M. B. McFarlane, Katelyn E. Connelly, Michael C. Gignac, Natalia Milosevich, Fraser Hof, Irina Paci, Catherine A. Musselman, Emily C. Dykhuizen, Casey J. Krusemark
ACS CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Zoey Warmerdam, Bianca E. Kamba, Alok Shaurya, XuXin Sun, Mary K. Maguire, Fraser Hof
Summary: The synthesis and structure-activity relationships of sulfonatocalix[4]arene hosts with novel substitutions were studied. These hosts displayed different binding affinities towards nicotine, nornicotine, and cotinine, with nicotine showing the strongest binding. NMR titrations revealed different host-guest interaction geometries for formyl-calix[4]arenes versus nitro-calix[4]arenes.
SUPRAMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Cara Gallo, Suma S. Thomas, Allison J. Selinger, Fraser Hof, Cornelia Bohne
Summary: Steady-state and stopped-flow photo-physical measurements were conducted to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 assembly and nicotine binding were determined, providing insight on how to optimize the system for sensing applications. Kinetics studies in artificial saliva showed minimal effects on the sensing ability of the system when moving to more complex media.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Allison J. Selinger, Natalie A. Cavallin, Anat Yanai, Inanc Birol, Fraser Hof
Summary: This study reports the synthesis of bivalent water-soluble calix[4]arene and calix[5]arene hosts, Super-sCx4 and Super-sCx5, as new broad-spectrum supramolecular binders of neuromuscular blocking agents. The hosts bind a variety of NMBAs by engaging both quaternary amines present, with high selectivity over other hydrophobic amines. This binding is achieved through linking two highly anionic p-sulfonatocalixarene building blocks in aqueous solution using the target bisquaternary amine NMBAs as a template.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Zoey Warmerdam, Bianca E. Kamba, My-Hue Le, Thomas Schrader, Lyle Isaacs, Peter Bayer, Fraser Hof
Summary: Methylated free amino acids are important targets for host-guest chemistry, with distinct recognition properties compared to methylated peptides and proteins. Different types of anionic hosts were studied for their binding to various methylated amino acids, with acyclic cucurbiturils showing stronger binding and unique selectivity patterns. Molecular modeling helps explain the preferences of the hosts and the overall selectivity patterns.
Article
Infectious Diseases
Amelia Richter, Darcy Sutherland, Hossein Ebrahimikondori, Alana Babcock, Nathan Louie, Chenkai Li, Lauren Coombe, Diana Lin, Rene L. Warren, Anat Yanai, Monica Kotkoff, Caren C. Helbing, Fraser Hof, Linda M. N. Hoang, Inanc Birol
Summary: Antimicrobial peptides (AMPs) are promising biological molecules for developing new therapeutics against antimicrobial resistance. In this study, 51 AMP candidates were bioinformatically identified and characterized. These AMPs demonstrated activity against bacterial pathogens and low toxicity to human cells. Sequence and structural analysis also predicted their antimicrobial activity.
Article
Chemistry, Organic
David King, Chelsea R. Wilson, Lukas Herron, Chun-Lin Deng, Shams Mehdi, Pratyush Tiwary, Fraser Hof, Lyle Isaacs
Summary: In this study, we investigated the molecular recognition properties of P[n]MQ towards (methylated) amino acids, amino acid amides, and post-translationally modified peptides using various techniques. Our findings showed that P6MQ is a strong receptor for N-methylated amino acid side chains, specifically recognizing the H3K4Me(3) peptide with high affinity (K-d = 16 nM) in phosphate buffered saline.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Meagan A. Beatty, Fraser Hof
Summary: Synthetic molecular recognition systems are increasingly utilized in solving applied problems in the life sciences. This tutorial review highlights the programming of host-guest molecular recognition in water, with examples and lessons focused on generalizable themes. It also surveys recent advances in host-guest chemistry within living cells and organisms.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Organic
Alok Shaurya, Graham A. E. Garnett, Melissa J. Starke, Mark C. Grasdal, Charlotte C. Dewar, Anton Y. Kliuchynskyi, Fraser Hof
Summary: The study reports an effective N,N-dimethyllysine (Kme2)-selective host and investigates its binding behavior in solution, as well as the relationship between its unusual conformational dynamics and guest-binding properties.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Meagan A. Beatty, Aidan T. Pye, Alok Shaurya, Belim Kim, Allison J. Selinger, Fraser Hof
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)