Article
Chemistry, Inorganic & Nuclear
Xiangwen Liao, Lianghong Liu, Yanhui Tan, Guijuan Jiang, Haihong Fang, Yanshi Xiong, Xuemin Duan, Guangbin Jiang, Jintao Wang
Summary: Novel ruthenium complexes functionalized with benzothiophene exhibited good antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa, with Ru(II)-3 showing the highest activity. Additionally, Ru(II)-3 demonstrated synergism with aminoglycoside antibiotics and potentially inhibited the regulatory function of SaCcpA. In vivo studies in a murine skin infection model further supported the antimicrobial efficacy of these complexes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Simona Braccini, Giacomo Provinciali, Lorenzo Biancalana, Guido Pampaloni, Federica Chiellini, Fabio Marchetti
Summary: The study presents diiron complexes with anticancer activity, along with a synthetic procedure. The reaction of the compounds may lead to iron oxidation and active monoiron species. Additionally, neutral complexes exhibit moderate inhibition on ovarian cancer cell lines.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Inorganic & Nuclear
Wen-Rui Lv, Rong-Jian Li, Zhen-Jiang Liu, Yan Jin, Zi-Jian Yao
Summary: A series of N,O-coordinate iridium(III) complexes with Schiff base ligands were synthesized for catalytic hydrogenation of nitro and carbonyl substrates, showing efficient catalytic activity and high yields. The molecular structures of the complexes were well characterized and the highest TON values were achieved for the hydrogenation reactions of carbonyl and nitro substrates.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Weiwei Zhang, Yu Sun, Jingyuan Wang, Xiaoyuan Ding, Endong Yang, Lisandra L. Martin, Dongdong Sun
Summary: The chiral ruthenium compound A-Ru prepared in the study exhibits high activity against tumor cells, inducing apoptosis and effectively inhibiting tumor growth and proliferation in in vivo experiments.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Organic
Chuan-Chuan Wang, Yan-Tao Yang, Qing-Long Wang, Xue-Hua Liu, Ya-Jing Chen
Summary: A regioselective and stereospecific reaction method has been developed for the preparation of functionalized 3,4-dihydro-2H-1,4-thiazines, while retaining the stereochemistry. This reaction is greatly influenced by the substituents on the aziridines and allows for the convenient synthesis of biologically interesting sulfoxide and sulfone analogues.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Hongzhuo Song, Xuemei Zhang, Gang Chen, Xiaochun He, Zhong Lian
Summary: A copper-catalyzed trifluoromethylthio-arylsulfonylation reaction is presented, which allows for the introduction of sulfone, SCF3, and allene moieties into one molecule simultaneously. This strategy offers mild reaction conditions, good substrate compatibility, and excellent regioselectivity. The resulting products have the potential for further conversion into valuable compounds. Initial investigations suggest a radical pathway for the reaction mechanism, and the SOgen used in this transformation is proven to be an uniquely effective SO2 surrogate.
Article
Chemistry, Inorganic & Nuclear
Bhaskar Paul, Richard R. Schrock, Charlene Tsay
Summary: A series of molybdenum complexes were prepared by adding different ligands and their structures and catalytic activities in metathesis reactions with cyclopentene were described. The bisnitrile complexes showed promising catalytic activities in the presence of B(C6F5)3.
Article
Biochemistry & Molecular Biology
Jose Manuel Veiga del Pino, Franco Scalambra, Cristina Bermejo-Casadesus, Anna Massaguer, Federico Garcia-Maroto, Antonio Romerosa
Summary: A water-soluble ruthenium complex was synthesized and characterized by various techniques. Its optical and biological properties were studied and compared with other ruthenium complexes. The complex showed high anticancer activity under visible light irradiation and exhibited no toxicity against red blood cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Vasileios Filippou, Martina Bubrin, Jan Fiedler, Wolfgang Kaim
Summary: The study investigates the potential application of the product obtained from the reaction between p-phenylenediamine and two equivalents of camphorquinone as a molecular bridge in metal complexes, analyzing the electronic structures of two different complexes using a combination of physical methods.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Chao Zhang, Xusheng Guo, Xuwen Da, Yishan Yao, Haihua Xiao, Xuesong Wang, Qianxiong Zhou
Summary: The BSA-coated UCNPs successfully delivered the Ru(ii) PACT agent to tumor tissues in vivo, with high efficiency and selectivity, utilizing the targeting ability of BSA and the enhanced permeability and retention effect of the nanoparticles.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Applied
Masanori Tayu, Ryuta Watanabe, Satoshi Isogi, Nozomi Saito
Summary: Treatment of ynamides with a catalytic amount of TpRuCl(PPh3)(2) leads to the construction of indole scaffolds known as privileged structure motifs. This reaction involves a cascade of 1,2-rearrangement and cyclization carrying out C-C bond formation via a ruthenium vinylidene intermediate, as revealed by deuterium-labeling experiments. Furthermore, the transformation of multi-functionalized ynamide, derived from a practical drug molecule, demonstrates the high functional group tolerance of this reaction.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Dong Luo, Tao Zuo, Ji Zheng, Zi-Hao Long, Xue-Zhi Wang, Yong-Liang Huang, Xiao-Ping Zhou, Dan Li
Summary: A stepwise reticular synthesis approach was used to construct a multicomponent MOF with orderly arranged chromophores, significantly improving the excited state properties of the material. DFT and TDDFT calculations suggest that synergistic charge transfer among different components in the MOF plays a crucial role in enhancing the optoelectronic properties of the material.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Hongbo Qi, Yupeng Zhao, Wencong Li, Shufeng Chen
Summary: A convenient Y(OTf)(3)-catalyzed cascade formal [4 + 2] cyclization approach for the formation of 1,4-benzoxazine scaffolds from benzoxazoles and propargyl alcohols has been developed. The mild and practical protocol allows for the preparation of a broad range of aldehyde-containing 1,4-benzoxazine compounds in moderate to excellent yields. Mechanistic studies revealed an S(N)1 nucleophilic substitution of benzoxazole with a propargyl cation in this transformation.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Yan Hu, Jiang Nan, Jiacheng Yin, Guanjie Huang, Xin Ren, Yangmin Ma
Summary: A novel Rh-catalyzed C-H/C-H alkenylation of N-arylmethanimines with vinylene carbonate has been reported, giving access to C3,C4-nonsubstituted quinolines. This process is simple, requires lower catalyst loading, and allows for postfunctionalization with bioactive molecules.
Article
Chemistry, Organic
Fu-Sheng He, Ping Bao, Feiyan Yu, Ling-Hui Zeng, Wei-Ping Deng, Jie Wu
Summary: By using CuOAc as the catalyst, a four-component reaction involving 1,3 enynes, diselenides, DABCO, (SO2)(2), and cycloketone oxime esters was successfully conducted to synthesize diverse cyanoalkylsulfonylated allenyl selenides. This reaction shows high functional group tolerance and a broad substrate scope, enabling regioselective formation of C-SO2 and C-Se bonds under mild conditions, with potential application in late-stage functionalization of drug-based molecules.
