期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 28, 页码 10999-11005出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2042035
关键词
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资金
- ICIQ Foundation
- Consolider Ingenio [CSD2006-0003]
Rational catalysis design on the basis of a detailed mechanistic understanding has been used to successfully develop the first efficient general Pd-catalyzed aromatic cyanation reaction under the highly sought after practicable conditions: (i) MCN (M = Na or K) as a cyanide source; (ii) low-boiling recyclable solvents; and (iii) minimal quantities of inexpensive, nontoxic promoters. The developed catalytic reaction converts aromatic bromides to the corresponding nitriles in 88-99% isolated yield with NaCN and 0.5-1.0 mol % of a t-Bu3P-monoligated Pd catalyst in MeCN-THF within 2 h at 70 degrees C. The process exhibits high functional group tolerance.
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