期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 5, 页码 1212-1215出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja109045j
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资金
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
- National Science Foundation [PIRE-0730072]
Chirality reversal of a residue in a peptide can change its mode of binding to a metal ion, as shown here experimentally by gas-phase IR spectroscopy of peptide metal ion complexes. The binding conformations of Li+, Na+, and H+ with the LL and DL stereoisomers of PhePhe were compared through IR ion spectroscopy using the FELIX free-electron laser. For the DL isomer, both Li+ and Na+ exclusively coordinate to the amide O atom, the carboxyl O atom, and one of the aromatic rings (the OOR conformation), while for the LL isomer, a mixture of the OOR and NOR conformations was found. The stereochemically induced change in conformation is shown to reflect the strength of an NH center dot center dot center dot pi interaction remote from the metal ion site. Protonated PhePhe shows no stereochemically induced variation in binding geometry.
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