期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 22, 页码 8528-8530出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2028712
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资金
- National Institutes of Health [R01 GM076710, R01 GM066174, P01A108321Y]
Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.
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