期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 35, 页码 13914-13917出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2056984
关键词
-
资金
- Ministry of Health and Welfare
- National Research Foundation of S. Korea: Nano Therapeutic and Diagnostic Center [2010-0027955]
- National Research Foundation of S. Korea [920340]
- National Research Foundation of S. Korea: WCU [R31-10071-0]
- National Research Foundation of S. Korea: MIRC [2011-0001319]
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanopartides that exhibited superb cellular uptake efficiency and gene silencing activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据