期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 10, 页码 3230-3233出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja1083915
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资金
- National Institutes of Health [HIVRAD 1PO1 AI066287, RR11973]
A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed azide-alkyne cycloaddition. The methodology efficiently provides chemically uniform heteromultimeric peptide constructs with enhanced binding, avidity, and specificity toward an established HIV-neutralizing human antibody, MAb b12. The versatile synthetic strategy serves as a powerful platform for the development of synthetic peptides as potential HIV-1 vaccine candidates.
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