Article
Biochemistry & Molecular Biology
Olga V. Kosmachevskaya, Elvira I. Nasybullina, Konstantin B. Shumaev, Natalia N. Novikova, Alexey F. Topunov
Summary: DNICs, a physiological form of nitric oxide in organisms, act as antioxidants and antiradical agents to protect hemoglobin from oxidative modification caused by peroxynitrite through intercepting peroxynitrite and free radicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
GiBaik Sim, Johannes Knolle, Frank Pollmann
Summary: We study the nonlinear response of nonintegrable 1D spin models using infinite matrix-product state techniques. As a benchmark, we calculate the 2D coherent spectroscopy for the soluble ferromagnetic transverse field Ising model. By introducing a longitudinal field, we observe the emergence of strong nonrephasinglike signals, and use a two-kink approximation to interpret the phenomena.
Article
Biochemistry & Molecular Biology
Jill B. Harland, Subhra Samanta, Nicolai Lehnert
Summary: In this study, three new synthetic model systems for NorBC were designed and characterized using spectroscopy. It was found that replacing the carboxylate ligand with a phenolate or pyridine group restored the reactivity towards NO, resulting in the formation of diiron dinitrosyl complexes. However, no N2O production was detected.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Wen-Chieh Chang, Wan-Tin Du, Yi-Xuan Lin, Ruei-Lin Jhang, Chung-Hung Hsieh
Summary: This article describes the synthesis and characterization of cationic, neutral, and anionic DNCCs, demonstrating the interconversions and NO releasing ability akin to what is observed in DNICs.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Wen-Chieh Chang, Wan-Tin Du, Yi-Xuan Lin, Ruei-Lin Jhang, Chung-Hung Hsieh
Summary: This article describes the synthesis and characterization of cationic, neutral, and anionic DNCCs, demonstrating the interconversions and NO releasing ability akin to what is observed in DNICs.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Nataliya A. Sanina, Galina Kozub, Tat'yana A. Kondrat'eva, Denis Korchagin, Gennadii Shilov, Roman B. Morgunov, Nikolai S. Ovanesyan, Alexander Kulikov, Tat'yana S. Stupina, Alexey A. Terent'ev, Sergey M. Aldoshin
Summary: This study synthesized two new anionic dinitrosyl iron complexes with S-donor ligands and investigated their structure and properties using various analytical methods. The experimental results showed that these complexes exhibited high cytotoxicity against human glioma cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Jose Osvaldo Guy Lezama, Mario Eduardo Arena, Norma Lis Robles
Summary: The isosteric replacement of the carbonyl functional group of paracetamol to obtain solid thioparacetamol was achieved. The compound was thoroughly characterized and the effects of solvents on its properties were investigated.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Review
Chemistry, Inorganic & Nuclear
Chi-Yen Tung, Yu-Ting Tseng, Tsai-Te Lu, Wen-Feng Liaw
Summary: Over the past two decades, extensive research has been conducted in the field of bioinorganic study of synthetic dinitrosyliron complexes (DNICs), encompassing synthetic methodology, spectroscopic discrimination, biological application of NO-delivery reactivity, and transformation of small molecules.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Seyedeh Maryam Salehi, Markus Meuwly
Summary: Azido-modified alanine residues are environment-sensitive infrared probes for protein structure and dynamics. They can be used to investigate the binding of ligands to the active site of lysozyme and the changes in spectroscopy and dynamics upon ligand binding. The results show specific differences in center frequencies, longtime decay, and frequency fluctuation correlation function between the ligand-free and ligand-bound protein. This makes the azide label a versatile and structurally sensitive probe for studying protein dynamics.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Seyedeh Maryam Salehi, Markus Meuwly
Summary: The azido-modified alanine residues are sensitive infrared probes that can be used to investigate protein structure and dynamics at specific sites. By analyzing the changes in center frequencies, vibrational decay, and frequency fluctuation correlation functions of labeled proteins, differences between ligand-free and ligand-bound states can be detected.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Microbiology
Kelsey M. McCoy, Keith J. Fritzsching, Ann E. McDermott
Summary: Bacterial replication relies on the cytoskeletal protein FtsZ, which forms filaments that scaffold and recruit other essential division proteins. The study demonstrates that E. coli FtsZ filaments are primarily composed of a tense conformation of the monomer, providing important insights into the structure and function of FtsZ filaments.
Review
Biochemistry & Molecular Biology
Anatoly F. Vanin
Summary: This article discusses the oxidative mechanism of M-DNICs formation and the effect of thiol-containing ligands on the stability of these complexes. The results demonstrate that thiol-containing ligands help M-DNICs maintain stability at neutral pH values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sejun An, Dabin Kim, Junggil Kim, Sang Kyu Kim
Summary: We report the first experimental observation of the excited dipole-bound state of cryogenically cooled nitromethane anion, and investigate the Feshbach resonances and anionic clusters using photofragment and photodetachment action spectra.
Article
Chemistry, Inorganic & Nuclear
Chuan-Kuei Chiang, Yu-Chiao Liu, Kai-Ti Chu, Jing-Ting Chen, Cheng-Yeh Tsai, Gene-Hsiang Lee, Ming-Hsi Chiang, Chien-Ming Lee
Summary: In this study, a dimeric and mononuclear Fe-NO model complex were synthesized and characterized, showing the formation of a thiolate-bridged bimetallic complex during the reduction of the mononuclear complex. The electronic structure of the bimetallic complex was described as a FeII/{Fe(NO)2}9 state, providing insights into the NO scrambling behavior in the activity of flavodiiron nitric oxide reductases (FNORs).
INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Analytical
M. Fraga-Corral, M. Carpena, P. Garcia-Oliveira, A. G. Pereira, M. A. Prieto, J. Simal-Gandara
Summary: Metabolomics is a young field of knowledge that seeks to understand metabolites and their mechanisms of action. Various techniques such as NMR, MS, and VS are used to study the metabolome of biological samples. Each technique has its own advantages and limitations, and the choice depends on the research objectives and nature of the samples. Metabolomics has applications in environmental, food, and health sciences, and its growth is supported by advances in analytical techniques and integration with other omics.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ming-Hsi Chiang, Vladimir Pelmenschikov, Leland B. Gee, Yu-Chiao Liu, Chang-Chih Hsieh, Hongxin Wang, Yoshitaka Yoda, Hiroaki Matsuura, Lei Li, Stephen P. Cramer
Summary: Nuclear resonance vibrational spectroscopy (NRVS) and density functional theory (DFT) are complementary tools for studying the vibrational structures of molecular systems. By applying NRVS and DFT to study the trans-[Fe-57(eta(2)-H-2)(H)(dppe)(2)][BPh4] complex, it has been shown that NRVS can quantitatively analyze sample composition.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Artur Braun, Debajeet K. Bora, Lars Lauterbach, Elisabeth Lettau, Hongxin Wang, Stephen P. Cramer, Feipeng Yang, Jinghua Guo
Summary: This article discusses the importance of the 100th anniversary of CASALE SA, a leading nitrogen fixation technology developer, and solutions for sustainable ammonia production. The article reviews the role of nitrogen in photosynthesis and biology, as well as the use of ammonia as fertilizer and an energy carrier. It also introduces novel analytical techniques and provides real-world examples of ammonia production and usage.
Article
Chemistry, Inorganic & Nuclear
Kenneth P. Caulfield, Zachary J. Tonzetich
Summary: This study investigates the reaction of iron corrole complex with alkyl halides, finding that the products have resistance to beta-H elimination and exhibit stability. The thermal decomposition of the products also reveals the formation of ethylene and acetaldehyde, as well as ethyl phenyl thioether when radical traps are present. The reaction of iron with NO results in the formation of iron nitrosyl species. Kinetic analysis of the alkylation reaction suggests that it follows either an S(N)2 type pathway or an outer-sphere electron transfer.
Article
Chemistry, Inorganic & Nuclear
C. Vance Thompson, Hadi D. Arman, Zachary J. Tonzetich
Summary: This study reveals different reaction pathways of iron catalysts in the hydrosilylation of aldehydes and ketones, depending on the precatalyst and substrate selection.
Article
Chemistry, Analytical
Jessie Wang, Lei Li, Hongxin Wang
Summary: Nuclear resonant vibrational spectroscopy (NRVS) is a spectroscopic method used to measure site specific vibrational information. In this study, a machine learning-based procedure was developed to automatically identify and smooth occasional spiky points in NRVS spectra.
VIBRATIONAL SPECTROSCOPY
(2022)
Article
Multidisciplinary Sciences
Xiang Feng, Gerrit J. Schut, Dominik K. Haja, Michael W. W. Adams, Huilin Li
Summary: Electron bifurcation allows energetically unfavorable biochemical reactions to occur. This study reports a new bifurcating flavoenzyme structure that couples hydrogen oxidation with NAD reduction through electron transfer. By elucidating its structure and function, we gain a deeper understanding of the electron transfer pathways in hydrogenases.
Article
Chemistry, Inorganic & Nuclear
Ana L. Narro, Hadi D. Arman, Zachary J. Tonzetich
Summary: This study employed iron-hydride and iron-boryl complexes to investigate the hydroboration of internal alkynes, revealing novel complexes as likely intermediates in the catalytic pathway.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Vance Thompson, Ana L. Narro, Hadi D. Arman, Zachary J. Tonzetich
Summary: Iron(II) phenylacetylide complexes of pyrrole-based pincer ligands were synthesized and characterized. In solution, the acetylide compounds of both ligands exist as square planar, intermediate-spin species. Interconversion between iron enynyl species was observed during catalytic alkyne dimerization.
Article
Microbiology
Francesco Smedile, Dionysis Foustoukos, Sushmita Patwardhan, Kelli Mullane, Ian Schlegel, Michael W. Adams, Gerrit J. Schut, Donato Giovannelli, Costantino Vetriani
Summary: Physiological and gene expression studies of deep-sea bacteria under pressure conditions similar to their natural habitat are important for understanding their growth kinetics and metabolic adaptations. This study focused on Campylobacterium Nautilia sp. strain PV-1, a piezophilic bacterium that displays unique protein expression patterns in response to different hydrostatic pressure regimes. The findings suggest that pressure adaptation extends to enzymes involved in central metabolic pathways.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Instruments & Instrumentation
Jessie Wang, Yoshitaka Yoda, Hongxin Wang
Summary: Nuclear resonant vibrational spectroscopy (NRVS) is an excellent modern vibrational spectroscopy method for revealing site-specific information inside complex molecules such as enzymes. This study evaluates the trends and mechanisms of zero-energy drifts (Delta E-i) in NRVS spectra and explores their correlation with energy scales (alpha(i)) between scans. Through detailed analysis, a new stepwise procedure for practical energy calibration is established, which uses Delta E-i values to correct for scan-dependent energy variations instead of conducting additional in situ calibration measurements. It is also proven that an additional instrument-fixed scaling constant (a(0)) exists to convert the calibrated energy axis (E') to the real energy axis (E-real). The calibrated real energy axis (E-real) has a preliminary error bar of +/- 0.1%, which is 4-8 times better than the current practical energy calibration procedure.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Ecology
Jennifer L. Goff, Yan Chen, Michael P. Thorgersen, Linh T. Hoang, Farris L. Poole II, Elizabeth G. Szink, Gary Siuzdak, Christopher J. Petzold, Michael W. W. Adams
Summary: Multiple heavy metal contamination is a common global problem that can disrupt microbial biogeochemical cycling. However, there is a lack of studies on the effects of combinations of heavy metals on bacteria. In this study, we assessed the impact of eight metal contaminants on cell processes using a multiomics approach. The combination of metals had unexpected effects on cell physiology, including a disruption of iron homeostasis and decreased activity of important enzymes. This research highlights the need for multi-metal studies to understand the impacts of complex contaminants on microbial systems.
Article
Environmental Sciences
Michael P. Thorgersen, Jennifer L. Goff, Farris L. Poole, Kathleen F. Walker, Andrew D. Putt, Lauren M. Lui, Terry C. Hazen, Adam P. Arkin, Michael W. W. Adams
Summary: Environmental contamination affects microbial communities by limiting diversity and total metabolic activity. The study investigates metal contamination in sediment and finds that the operational speciation of certain elements changes due to contamination. Furthermore, the availability of essential elements also changes. The decreased operational speciation of phosphorus in contaminated sediment may increase the dependence of microbial communities on other phosphorus sources.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Inorganic & Nuclear
Hongxin Wang, Songping D. Huang, Lifen Yan, Michael Y. Hu, Jiyong Zhao, Ercan E. Alp, Yoshitaka Yoda, Courtney M. Petersen, Matthew K. Thompson
Summary: We have performed and analyzed the first combined Eu-151 and Fe-57 nuclear resonant vibrational spectroscopy (NRVS) for naturally abundant KEu(iii)[Fe(ii)(CN)(6)] and Eu(iii)[Fe(iii)(CN)(6)] complexes. The results confirm the coordination positions of Eu(iii) and Fe(iii)/Fe(ii) in these complexes, and provide insights for the design and evaluation of their nanoparticles as potential contrast agents for magnetic resonance imaging.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Ana L. Narro, Hadi D. Arman, Zachary J. Tonzetich
Summary: Iron(II) boryl complexes of the pyrrole-based pincer ligand have been synthesized and investigated for their insertion reactivity. These complexes exhibit stability and react with unsaturated substrates to form various useful products.
DALTON TRANSACTIONS
(2022)
Meeting Abstract
Biophysics
Courtney M. Petersen, Hongxin Wang, Simon J. George, Yoshitaka Yoda, Nobutomo Nagasawa, Hiroaki Matsuura, Stephen P. Cramer, Matthew K. Thompson
BIOPHYSICAL JOURNAL
(2022)