Article
Chemistry, Medicinal
Maria Eugenia Garcia-Rubino, Antonio Matilla-Hernandez, Antonio Frontera, Luis Lezama, Juan Niclos-Gutierrez, Duane Choquesillo-Lazarte
Summary: This study aims to develop a metal chelate capable of recognizing two molecules of an adenine nucleoside. By using Cu-2(mu-EDTA) as a receptor model, the synthesized compound was successfully characterized through various methods. The efficient cooperation between the metal chelate and nucleoside was demonstrated, supported by theoretical calculations.
Article
Chemistry, Multidisciplinary
Tamyris T. da Cunha, Cleverton O. C. da Silveira, Vitor M. M. Barbosa, Willian X. C. Oliveira, Eufranio N. da Silva Junior, Fabio F. Ferreira, Emerson F. Pedroso, Cynthia L. M. Pereira
Summary: Three new air-stable coordination compounds containing copper and zinc coordinated with oxamate ligands were successfully synthesized and characterized. These compounds exhibit different crystal structures and magnetic behaviors, with the phenol group in the oxamate ligand leading to distinct hydrogen bond patterns in the crystal packing.
Article
Chemistry, Multidisciplinary
Masakazu Murase, Yoshifumi Maegawa, Masataka Ohashi, Yasutomo Goto, Naonari Sakamoto, Takamasa Nonaka, Takeshi Uyama, Takeo Arai
Summary: A trinuclear Zn(II) cryptate complex (Zn3L) was designed and demonstrated to rapidly fix CO2 through carbonation reaction. The CO2 fixation performance of Zn3L surpassed that of a standard CO2 absorbent, KOH(aq) solution, without the need for added base. The complex exhibited reversibility and the ability to capture dilute CO2, making it a promising candidate for CO2 fixatives.
Article
Biochemistry & Molecular Biology
Huixiang Wu, Yujun Zhang, Hao Chen, Jing Liu, Lili Xiu, Jianying Huang
Summary: In this study, we synthesized cryptate copper(II) and complexed it with sulfonate chitosan (SCS). The resulting complexes were evaluated for their antioxidant properties and their antibacterial/biofilm inhibitory activity against Pseudomonas aeruginosa PAO1 (P. aeruginosa PAO1). It was found that cryptate copper(II) exhibited the best antioxidant activity and significant antibacterial activity against P. aeruginosa PAO1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Alexander Brinkmeier, Kristian E. Dalle, Lorenzo D'Amore, Roland A. Schulz, Sebastian Dechert, Serhiy Demeshko, Marcel Swart, Franc Meyer
Summary: The study revealed the strong binding of alkali metal ions to reactive cis-peroxo dicopper(II) intermediates, affecting the electronic and electrochemical properties of the core structure and leading to changes in charge transfer dynamics. This has significant implications for understanding oxidation processes in synthetic and natural environments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Immunology
Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Ryota Sato, Shin-Ichiroh Saitoh, Yusuke Murakami
Summary: Toll-like receptors (TLRs) respond to pathogen constituents by recognizing and degrading nucleic acids with the help of nucleases. However, these nucleases also negatively regulate TLR responses by degrading ligands. Dysregulation of nucleic acid metabolism in endosomal compartments drives TLR-dependent pathologies in human diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wenjie Tao, Curtis E. Moore, Shiyu Zhang
Summary: A redox-neutral S-nitrosation of thiol has been achieved at a dicopper(I,I) center, providing new insights into the mechanism of S-nitrosation. The reaction yielded thiol and di-S-nitrosothiol complexes, indicating that S-nitrosation proceeds through similar intermediate species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Medicine, Research & Experimental
Min Ae Lee-Kirsch
Summary: Lack of SKIV2L activates mTORC1 signaling, leading to impaired skin barrier and T cell imbalance, which causes autoinflammatory skin disease. Rapamycin may be a potential therapy for THES2.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Immunology
Christine Wuebben, Eva Bartok, Gunther Hartmann
Summary: The success of RNA applications, such as mRNA vaccines and RNA therapeutics, holds great promise for future drug development. Understanding innate RNA sensing can lead to further improvements in mRNA vaccines and RNA therapeutics.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Debojyoti Mukherjee, Probal Nag, Albert A. Shteinman, Sivaranjana Reddy Vennapusa, Ujjwal Mandal, Mainak Mitra
Summary: A dinuclear copper(ii) complex has been synthesized and characterized, showing weak ferromagnetic interactions and high catecholase activity. A reaction mechanism has been proposed based on experimental findings.
Article
Chemistry, Physical
Kiryl Trusau, Marina Kirillova, Vania Andre, Andrew Usevich, Alexander M. Kirillov
Summary: The study synthesized two new copper(II) coordination compounds as homogeneous catalysts for the oxidative functionalization of cycloalkanes. The structures of these compounds were characterized using standard methods including single-crystal X-ray diffraction.
MOLECULAR CATALYSIS
(2021)
Article
Chemistry, Inorganic & Nuclear
Sandeep Kumar, Nivedita Chaudhri, W. Ryan Osterloh, Karl M. Kadish, Muniappan Sankar
Summary: A series of nickel(ii) monobenzochlorins and monobenzoporphyrins were synthesized and characterized for their physicochemical and anion sensing properties. One compound exhibited a unique conformation and reversible response to basic anions, while another selectively detected cyanide ions irreversibly.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Addison N. Desnoyer, Amelie Nicolay, Micah S. Ziegler, K. Lakshmi, Thomas R. Cundari, T. Don Tilley
Summary: A new dicopper nitrenoid complex was prepared by formal oxidative addition of the nitrenoid fragment to a dicopper(I) center, showing powerful H atom abstraction ability and achieving clean H atom transfer process.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Meng Sha, Li Rao, Weiqing Xu, Ying Qin, Rina Su, Yu Wu, Qie Fang, Hengjia Wang, Xiaowen Cui, Lirong Zheng, Wenling Gu, Chengzhou Zhu
Summary: Researchers developed a chiral histidine-coordinated copper core grafted onto Zr-based metal-organic framework, creating a biomimetic catalyst with catechol oxidase-like activity. The catalyst demonstrated efficient and selective enzyme-mimicking catalytic processes, offering insights into the catalytic mechanism of nanozymes.
Article
Chemistry, Physical
Mikalai A. Artsiusheuski, Jeroen A. van Bokhoven, Vitaly L. Sushkevich
Summary: The one-step valorization of natural gas is still a challenge, and converting methane to methanol via chemical looping over copper-containing zeolites seems to be a promising route. CuMFI is one of the earliest successful methods, but the structure of the active sites in CuMFI and the influence of copper loading and Si/Al ratio on the copper speciation are still not well understood. It has been found that the Cu/Al ratio determines the selectivity of methane conversion in CuMFI by controlling the structure of the active dicopper sites.
Article
Nanoscience & Nanotechnology
Greta Bergamaschi, Angelo Musico, Roberto Frigerio, Alessandro Strada, Andrea Pizzi, Benedetta Talone, Jacopo Ghezzi, Alfonso Gautieri, Marcella Chiari, Pierangelo Metrangolo, Renzo Vanna, Francesca Baldelli Bombelli, Marina Cretich, Alessandro Gori
Summary: This study presents a composite hydrogel obtained by combining a self-assembling peptide with low-temperature gelling agarose, which demonstrates simple and robust application in the fabrication of microdroplet arrays, overcoming hurdles and limitations commonly associated with 3D hydrogel assays.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Riccardo Mobili, Giovanni Preda, Sonia La Cognata, Lucio Toma, Dario Pasini, Valeria Amendola
Summary: A chiral cage is proposed as an effective chiroptical sensor for detecting perrhenate in water, fruit juice, and artificial urine media. The key mechanism for chiroptical sensing involves changes in the dihedral angle of the binaphthyl unit and H-bonding with the guest, leading to significant changes in the CD signal.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Alessandro Marchetti, Andrea Pizzi, Greta Bergamaschi, Nicola Demitri, Ulrike Stollberg, Ulf Diederichsen, Claudia Pigliacelli, Pierangelo Metrangolo
Summary: Iodination is a successful labelling strategy to gain structural insights into proteins and biomolecules. However, interactions driven by iodine may significantly alter the self-assembly behavior of smaller biomolecular systems. In this study, an aliphatic bis-iodinated amino acid was synthesized and incorporated into a custom pentapeptide, leading to enhanced fibrillogenic behavior and amyloid fibril formation.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Greta Bergamaschi, Pierangelo Metrangolo, Valentina Dichiarante
Summary: Researchers are continuously seeking versatile and high-performing optical bioimaging and biosensing probes, including photoluminescent metal nanoclusters. These nanoclusters, with molecule-like quantization properties, have great potential for applications in biologically relevant molecules.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Nazeeha Ayaz, Valentina Dichiarante, Claudia Pigliacelli, Jacopo Repossi, Lara Gazzera, Marta Borreggio, Daniele Maiolo, Cristina Chirizzi, Greta Bergamaschi, Linda Chaabane, Elisa Fasoli, Pierangelo Metrangolo, Francesca Baldelli Bombelli
Summary: Fluorine-magnetic resonance imaging (F-19-MRI) is a promising diagnostic technique that can be easily translated for clinical use, requiring appropriate delivery systems for highly omniphobic fluorinated probes. The use of the film-forming protein hydrophobin offers a sustainable method to change the wettability of fluorinated surfaces, demonstrated here to stabilize F-19-MRI probes in aqueous solution as nanoparticles for imaging applications.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Sonia La Cognata, Riccardo Mobili, Chiara Milanese, Massimo Boiocchi, Mattia Gaboardi, Donatella Armentano, Johannes C. Jansen, Marcello Monteleone, Ariana R. Antonangelo, Mariolino Carta, Valeria Amendola
Summary: Two novel imide/imine-based organic cages were prepared and studied as materials for selective separation of CO2 from N-2 and CH4. The cages showed selectivity for CO2 over N-2 and CH4 in gas adsorption and membrane filling, leading to improved gas transport properties and CO2 selectivity in mixed-matrix membranes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Andrea Pizzi, Lorenzo Sori, Claudia Pigliacelli, Alfonso Gautieri, Clara Andolina, Greta Bergamaschi, Alessandro Gori, Pierre Panine, Antonio Mattia Grande, Markus B. Linder, Francesca Baldelli Bombelli, Monica Soncini, Pierangelo Metrangolo
Summary: Bromination is used to promote elastic behavior in a short peptide derived from resilin, resulting in elastic and resilient hydrogels with self-healing behavior. The increased non-covalent interactions, particularly halogen bonds, contribute to the structural recovery of the peptide-based hydrogel.
Article
Biochemistry & Molecular Biology
Valentina Gazzola, Pietro Grisoli, Valeria Amendola, Giacomo Dacarro, Carlo Mangano, Piersandro Pallavicini, Antonio Poggi, Silvia Rossi, Barbara Vigani, Angelo Taglietti
Summary: This paper reports on the preparation of Imidazole-functionalized glass surfaces and demonstrates the use of a dinuclear Cu(II) complex to interact with deprotonated grafted imidazole moieties. This supramolecular approach leads to the development of an antimicrobial surface with a strong microbicidal effect using low amounts of the copper complex.
Article
Pharmacology & Pharmacy
Dalila Miele, Milena Sorrenti, Laura Catenacci, Paolo Minzioni, Giorgio Marrubini, Valeria Amendola, Marcello Maestri, Paolo Giunchedi, Maria Cristina Bonferoni
Summary: In this study, poly lactic-co-glycolic acid (PLGA) based nanoparticles (NPs) were proposed as carriers for indocyanine green (ICG), and fluorescence quenching experiments were conducted by studying the interaction between ICG and chitosan oleate (CS-OA). The results showed that associating ICG with NPs can reduce cell viability after laser irradiation, opening up new possibilities for utilizing PDT mechanism in cancer therapy.
Article
Biochemistry & Molecular Biology
Fabio Schifano, Simone Dell'Acqua, Stefania Nicolis, Luigi Casella, Enrico Monzani
Summary: The study explores the interplay between α-Synuclein (aS), dopamine (DA), and iron in Parkinson's disease etiology. At high DA:Fe molar ratios, the formation of the [Fe-III(DA)(2)](-) complex hinders the interaction with aS peptides. However, at lower ratios, the peptide competes with one of the two coordinated DA molecules. Post-translational modifications of the peptide, such as oxidation and phosphorylation, play crucial roles in aS aggregation and affinity for iron(III). Moreover, the presence of a membrane-like environment enhances the peptide's effect on DA oxidation and complex formation and decomposition.
Article
Infectious Diseases
Tecla Ciociola, Laura Giovati, Tiziano De Simone, Greta Bergamaschi, Alessandro Gori, Valerio Consalvi, Stefania Conti, Alberto Vitali
Summary: Antimicrobial resistance, including fungal resistance, is a global public health concern. This study aimed to search for potential alternatives to conventional drugs, focusing on proline-rich antimicrobial peptides (PrAMPs) from plants. Two candidates showed potent activity against Candida albicans and Candida glabrata strains, including resistant isolates, with unique mechanistic properties.
Review
Chemistry, Medicinal
Alessandro Gori, Giulia Lodigiani, Stella G. Colombarolli, Greta Bergamaschi, Alberto Vitali
Summary: Cell-penetrating peptides (CPPs) are a class of peptides with the remarkable ability to cross cell membranes and deliver various cargoes into cells. They are extensively investigated for drug delivery in diseases such as cancer, diabetes, and genetic disorders. Despite sharing common structural features, CPPs are a highly diverse group of elements. This review summarizes their characteristics, distinctive features, mechanisms, and commonly used techniques for studying their structure and function, highlighting current gaps and future perspectives in the field of drug delivery and therapeutics.
Article
Cell Biology
Andrea Ridolfi, Laura Conti, Marco Brucale, Roberto Frigerio, Jacopo Cardellini, Angelo Musico, Miriam Romano, Andrea Zendrini, Laura Polito, Greta Bergamaschi, Alessandro Gori, Costanza Montis, Stefano Panella, Lucio Barile, Debora Berti, Annalisa Radeghieri, Paolo Bergese, Marina Cretich, Francesco Valle
Summary: The overlapping physicochemical properties of lipoproteins and extracellular vesicles pose challenges in isolating and characterizing these biogenic lipid nanoparticles. This study presents a rapid nanomechanical screening method using atomic force microscopy to determine the diameter and stiffness of individual nanometric objects in mixed lipoprotein and extracellular vesicle samples. The method enables discrimination of co-isolated vesicles and lipoproteins based on their specific nanomechanical readouts and provides insights into the relationship between mechanical behavior and structural features. The approach is label-free and can be used to assess the purity of lipoprotein and extracellular vesicle isolates efficiently.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Chemistry, Multidisciplinary
Sonia La Cognata, Valeria Amendola
Summary: Organic cages have attracted great interest in the scientific community due to their unique features, such as simple synthesis, structural tunability, and high selectivity. In the past decade, organic cages have been extensively studied and applied as chemosensors, separation agents, and membrane materials.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sonia La Cognata, Donatella Armentano, Nicoletta Marchesi, Pietro Grisoli, Alessia Pascale, Marion Kieffer, Angelo Taglietti, Anthony P. Davis, Valeria Amendola
Summary: This study reports a novel organic cage as a potential antimicrobial and antifungal agent. Experimental results demonstrate that the cage can bind and transport specific anions and exhibit antimicrobial activity against Staphylococcus aureus.
CHEMISTRY-SWITZERLAND
(2022)
