期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 8, 页码 2532-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja910696x
关键词
-
资金
- NSF [CHE-0450638]
- German Academic Exchange Service
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0848280] Funding Source: National Science Foundation
The bicyclo[5.3.0]decane skeleton is one of the most commonly encountered bicyclic Subunits in nature and the core scaffold of a wide range of targets of structural, biological, and therapeutic importance. Prompted by the interest in Such structures, we report the first studies of metal-catalyzed [5+2] cycloadditions of vinylcyclopropanes (VCPs) and enynones. The resultant efficiently formed dienone cycloadducts serve as substrates for Subsequent Nazarov cyclizations and as intermediates for single-operation [5+2]/Nazarov serial reactions and catalytic cascades. In many cases the one-flask process can be carried Out in shorter reaction times and with comparable or superior yields to the two-flask procedure. Significantly, a single catalyst can be used to mediate both transformations. These [5+2]/Nazarov reaction sequences and cascades collectively provide strategically novel and facile access to the bicyclo[5.3.0]decane skeleton from simple and readily available components.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据