Article
Chemistry, Analytical
Zhengang Han, Xinyao Yu, Yuyang Sang, Yanhong Xu, Aijuan Zhao, Xiaoquan Lu
Summary: By employing an enhanced aromaticity strategy, a series of cyclopentadienols with excellent AIE-ECL properties were synthesized. It was found that different substituents significantly influenced the ECL emission by affecting the characteristic absorption peak intensity ratio in UV-vis spectra and LUMO-HOMO energies. The cyclopentadienol with an electron-withdrawing fluorine substituent demonstrated the best ECL performance and showed a wide response range to pH.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhuangzhuang Ru, Yue Jia, Yu Du, Yujie Han, Nuo Zhang, Xiang Ren, Qin Wei
Summary: Developing a convenient assay method is crucial for clinical treatment due to the low abundance of bleomycin. This study proposes an electrochemiluminescence biosensor using zirconium-based metal-organic frameworks for sensitive detection of bleomycin. The use of a long guanine-rich single-stranded DNA and the auxiliary role of exonuclease III enhance the electrochemiluminescence efficiency. The negative correlation between electrochemiluminescence intensity and bleomycin concentration enables the accurate detection of bleomycin in the range from 5.0 nM to 50 μM, with a limit of detection of 0.50 nM.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ali Firoozbakhtian, Morteza Hosseini, Yiran Guan, Guobao Xu
Summary: Point-of-care testing is crucial in resource-poor areas, and this study presents the development of an integrated MXene-modified SEES device for visual and high-throughput ECL immunoassays. The developed system achieved a remarkable minimum virus detection limit and showed promising potential for efficient point-of-care testing.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhiyuan Xu, Fan Wu, Da Zhu, Haomin Fu, Zhen Shen, Jianping Lei
Summary: In this research, a boron dipyrromethene (BODIPY)-based metal-organic framework (MOF) nanoemitter was designed for the first time. The ordered arrangement of BODIPY molecules in the framework helps to enhance the electrochemiluminescence (ECL) intensity by suppressing non-radiative dissipation. Consequently, an ECL biosensor was developed for telomerase detection and showed excellent performance in real samples.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Kenneth Chu, Jonathan R. Adsetts, Jing Ma, Congyang Zhang, Mahdi Hesari, Liuqing Yang, Zhifeng Ding
Summary: In this study, an absolute method using a photon-counting device was developed to determine the electrochemiluminescence quantum efficiency of coreactant systems. The efficiency of the Ru(bpy)(3)(2+)/ tri-n-propylamine (TPrA) ECL coreactant system was found to be 10.0 +/- 1.1%, showing a 3-fold enhancement compared to annihilation pathways. These findings suggest a promising approach in the expanding field of ECL research.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Xiaodan Gou, Yiwen Zhang, Zejing Xing, Cheng Ma, Changjie Mao, Jun-Jie Zhu
Summary: In this study, a site-selective heat boosting electrochemiluminescence microscopy technique was reported. By generating a micron-scale heat point in situ at the electrode-solution interface, a 63-fold enhancement in luminescence intensity and a 0.2 V advance in applied voltage were achieved. Experimental results and finite element simulation showed that the fundamental reasons for this phenomenon were accelerated reaction rate and thermal convection via a photothermal effect. The concentrated electrochemiluminescence not only boosted the contrast of single cells by 20.54 times but also enabled the site-selective cell-by-cell analysis of the heterogeneous membrane protein abundance. This electrochemical visualization method has great potential in the highly sensitive and selective analysis of local electron transfer events.
Article
Chemistry, Multidisciplinary
Jilin Liu, Kai Yu, Hong Zhang, Jing He, Jie Jiang, Hai Luo
Summary: The EC-NR-MS technique developed in this study successfully identified important reductive intermediates in electrochemical reactions, which helps to clarify previously unproven electrochemiluminescence (ECL) reaction mechanisms.
Article
Chemistry, Multidisciplinary
S. Mohsen Beladi-Mousavi, Gerardo Salinas, Laurent Bouffier, Neso Sojic, Alexander Kuhn
Summary: A study reports the generation of electrochemiluminescence (ECL) in confined free-standing 2D spaces, exemplified by surfactant-based air bubbles. By trapping graphene sheets as bipolar ECL-emitting electrodes in the ultrathin walls of the bubbles, the required potential for ECL generation is significantly reduced. This study highlights the key advantages of a 2D environment for wireless activation of ECL at low potentials.
Article
Chemistry, Analytical
Elena Villani, Shinsuke Inagi
Summary: Bipolar electrochemistry is a powerful technique for synthesizing functional materials, but the distribution of potential gradient is affected by cell geometry and monitoring is challenging. The use of electro-chemiluminescence as an imaging technique offers a valuable and reliable method for mapping potential distribution in bipolar electrochemical systems.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Xinxin Wang, Zhuofeng Xie, Yuyang Dai, Xiaona Liu, Manling Bao, Chen Liu, Qiqi Han, Chunmeng Liu, Yuanting Su
Summary: In this study, the first series of radicals derived from boron-dipyrromethene (DPMBF2)-D-Trip and its heavier analogues (DPMAlI2)-D-Trip and (DPMGaI2)-D-Trip were successfully isolated and structurally characterized. Spectroscopy analysis, X-ray crystallography, and theoretical calculations revealed the increasing delocalization over the dipyrromethene scaffold upon one-electron reduction, with the unpaired electrons mainly delocalized over the dipyrromethene backbone and negligible spin density on the group 13 element centers.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
William H. Garcia-Santos, Javier Ordonez-Hernandez, Monica Farfan-Paredes, Hiram M. Castro-Cruz, Norma A. Macias-Ruvalcaba, Norberto Farfan, Alejandro Cordero-Vargas
Summary: A new metal-free photocatalyst, dibrominated BODIPY, has been reported with similar properties to the common photocatalyst Ru(bpy)(3)Cl-2. This catalyst can be used to develop new reaction sequences in organic synthesis, showing potential in the formation of various compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiawen Li, Caiqian Wang, Wenjing Wang, Ling Zhao, Heyou Han
Summary: In this study, a dual-signal immunosensor was developed for highly sensitive detection of rabies virus (RABV) using electrochemiluminescence resonance energy transfer (ECL-RET) and electrochemical (EC) methods. The combination of dendritic mesoporous silica nanoparticles (DMSNs) and manganese oxide nanoparticles (MnOx) allowed for the detection of RABV glycoprotein through two different signaling pathways.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ran Chen, Xin Wang, Kaiqing Wu, Songqin Liu, Yuanjian Zhang
Summary: This study presents a model for the electrochemical oxidation of luminol and investigates the electron transfer kinetics in alkaline solutions using a finite element method simulation. The results show that pH and molecular structure influence the oxidation and adsorption effects of luminol. In addition, the study reveals that the ECL intensity can be enhanced through adsorption effects.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sijia Li, Shengtao Zhang, Jiayue Shi, Xia Yang, Huiping Sun, Yan Li
Summary: A sensitive and non-separation electrogenerated chemiluminescence (ECL) biosensing method was developed to detect 5-hydroxymethylcytosine modified double-strand DNA (5-hmC-dsDNA) using a poly (diallyl dimethyl ammonium chloride)/ferrosoferric oxide/molybdenum disulfide (PDDA/Fe3O4/MoS2) nanocomposite and DNA nanomachine. The method overcame steric resistance by fixing the negatively charged 5-hmC-dsDNA onto the positively charged and magnetic PDDA/Fe3O4/MoS2 nanocomposite, and magnetic fields separation was possible. The method showed a broader linear range and a low limit of detection, and it demonstrated potential for early clinical diagnosis of disease.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Sara Knezevic, Emily Kerr, Bertrand Goudeau, Giovanni Valenti, Francesco Paolucci, Paul S. Francis, Frederic Kanoufi, Neso Sojic
Summary: Electrochemiluminescence (ECL) microscopy is a new technique used for imaging single entities and cells. In this study, a bimodal and bicolor approach was developed to record both positive ECL (PECL) and shadow label-free ECL (SECL) images of single cells. This dual approach enables the imaging of cell morphology and can contribute to multimodal ECL imaging and bioassays.
ANALYTICAL CHEMISTRY
(2023)