Article
Chemistry, Physical
Hui Sun, Huijian Shang, Bin Cui
Summary: Asymmetric catalysis using a chiral (Salen)Mn(III) complex has been successfully applied to highly enantioselective intramolecular haloamination reactions of alkenes. Experimental results suggest that the polarization of the C5-C6 bond has a significant effect on the regioselectivity of the products.
Article
Chemistry, Multidisciplinary
Pooja Chaudhary, Geeta Devi Yadav, Krishna K. Damodaran, Surendra Singh
Summary: New chiral Mn(III)-salen complexes were synthesized and evaluated for the asymmetric epoxidation of styrene, showing high yields and promising catalytic activity; the recovered catalysts could be reused for multiple runs, demonstrating good stability and durability.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Pooja Chaudhary, Christophe Len, Surendra Singh
Summary: New chiral salen ligands with imidazolium based ionic liquids were synthesized and reacted with Mn(OAc)2.4H2O to form IL tagged chiral salen-MnIII complexes. These complexes exhibited excellent catalytic activity in the oxidative kinetic resolution.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Yongbing Liu, Huanlin Diao, Guorong Hong, Jonathan Edward, Tao Zhang, Guoqiang Yang, Bin-Miao Yang, Yu Zhao
Summary: We have developed an enantioconvergent approach to chiral N-heterocycles using racemic diols and primary amines via cost-effective borrowing hydrogen annulation. The discovery of a chiral amine-derived iridacycle catalyst was crucial for achieving high efficiency and enantioselectivity in the one-step formation of two C-N bonds. This catalytic method provides quick access to a diverse range of enantioenriched pyrrolidines, including key precursors for valuable drugs like aticaprant and MSC 2530818.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yu-Feng Zhang, Xiao-Yang Dong, Jiang-Tao Cheng, Ning-Yuan Yang, Li-Lei Wang, Fu-Li Wang, Cheng Luan, Juan Liu, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu
Summary: This study demonstrates the successful use of sulfoximines as ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides, achieving high yields and enantioselectivity. The obtained alpha-chiral primary amines can be converted to various synthetic building blocks, ligands, and drugs, highlighting the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Lei Yang, Weidong Shang, Li Zhang, Xia Zhang
Summary: The first Ni-catalyzed asymmetric reductive coupling of 2-aza-butadiene with aldehydes was achieved, leading to the synthesis of chiral gamma-secondary amino alcohols. This reaction shows good enantioselectivity and tolerance towards various functional groups, and may provide a complementary method to noble-metal-catalyzed protocols. Competition reactions demonstrated that 2-aza-butadiene is a more reactive coupling component than its full-carbon analogue, 1,3-butadiene. Interestingly, the reaction also produced beta-siloxyl imines, aza-aldol-type products that are difficult to access using conventional methods.
Article
Chemistry, Organic
Lenin Kumar Verdhi, Natalia Fridman, Alex M. Szpilman
Summary: A chiral nitroxide catalyst, generated in situ by a readily prepared chiral hydroxylamine precatalyst, in combination with a copper co-catalyst, serves as an environmentally friendly terminal oxidant for the enantioselective oxidative kinetic resolution of racemic axially chiral N-arylpyrrole alcohols, providing high enantioselectivity and reaction efficiency.
Article
Multidisciplinary Sciences
Jie Wang, Wei-Feng Zheng, Xue Zhang, Hui Qian, Shengming Ma
Summary: This study reports the synthesis of non-readily available enantioenriched tetrasubstituted allenes through rhodium-catalyzed reactions controlled by steric hindrance. Detailed mechanistic experiments and density functional theory studies reveal the mechanism behind the formation of different stereochemistry under different reaction conditions. A stereodivergent protocol to construct the enantiomer of optically active tetrasubstituted allenes from the same starting materials is successfully developed based on these mechanistic understandings.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Dong Han, Yuanfeng Li, Ya-Ping Han, Hong-Yu Zhang, Yuecheng Zhang, Jiquan Zhao
Summary: In this study, four different sidearm-containing Salen-Mn(III) complexes were synthesized and compared. It was found that the complex with a D-Boc-N-proline sidearm exhibited the best catalytic activity in the asymmetric epoxidation reaction. The steric hindrance and appropriate configuration of this sidearm facilitated the approach of olefins to the active center, resulting in improved reaction yields and enantioselectivities.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Organic
Min Zhang, Yuqi Ji, Zheng Zhang, Chun Zhang
Summary: The copper-catalyzed hydrosilylation reaction of silyl orboryl alkene has been successfully developed, enabling the practical synthesis of chiral geminated disilyl and borylsilyl reagents. These reagents are versatile organosilanes that can be used in various organic synthesis reactions. Experimental results have demonstrated the compatibility of this reaction with a wide range of functional groups, and the utility of the gem-dimetal compounds prepared through this chemistry has been well illustrated through further transformations.
Article
Chemistry, Inorganic & Nuclear
Marcello B. Solomon, Carol Hua, Bun Chan, Tamara L. Church, Seth M. Cohen, Clifford P. Kubiak, Katrina A. Jolliffe, Deanna M. D'Alessandro
Summary: The new metal-organic framework containing a Mn(ii) salen complex undergoes a reversible crystalline-to-amorphous transformation, and is stable to a one-electron reduction at more anodic potentials than the corresponding discrete complex, as supported by experimental studies and computational calculations.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Organic
Chun-Tai Hung, Chun-Wei Lu, Shi-Han Huang, Yin-Feng Lu, Hsiang-Chi Chou, Cheng-Che Tsai
Summary: This research utilizes chiral sulfinamides as nucleophiles in intramolecular allylic substitution and sequential aerobic oxidation with aza-Michael addition reactions, achieving good yields of chiral isoindolines and high diastereoselectivities.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jun Li, Xiao Song, Yan Wang, Junrong Huang, Hengzhi You, Fen-Er Chen
Summary: Highly enantioselective Cu-catalyzed asymmetric allylic alkylation of racemic inert cyclic allylic ethers is achieved in this work. The use of Grignard reagents in combination with BF3.OEt2 and CuBr.SMe2/ L2 plays a key role in enabling the employment of low reactive allylic substrates. The approach also demonstrates advantages in constructing a stereogenic center involving sterically hindered nucleophiles.
Article
Chemistry, Organic
Jian Song, Wen-Hua Zheng
Summary: A highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been developed using chiral organotin-catalyzed intermolecular acylation. The process can be carried out under mild reaction conditions and has a broad substrate scope, allowing for the separation of the corresponding products and highly enantioselective recovery of tertiary alcohols with s factors up to >200.
Article
Chemistry, Organic
Chen-Qiang Deng, Jin Deng
Summary: A highly efficient Ni-catalyzed asymmetric hydrogenation method has been developed to produce a series of aryl lactones with high yields and excellent enantioselectivities. This method can be smoothly carried out on a gram scale with a low catalyst loading.
Article
Chemistry, Multidisciplinary
Kaitlyn M. Logan, Stephen R. Sardini, Sean D. White, M. Kevin Brown
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Kevin B. Smith, Yuan Huang, M. Kevin Brown
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Chemistry, Multidisciplinary
Johannes M. Wiest, Michael L. Conner, M. Kevin Brown
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Chemistry, Multidisciplinary
Allison M. Bergmann, Adam M. Oldham, Wei You, M. Kevin Brown
CHEMICAL COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Pin Gao, Liang-An Chen, M. Kevin Brown
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Allison M. Bergmann, Stanna K. Dorn, Kevin B. Smith, Kaitlyn M. Logan, M. Kevin Brown
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Johannes. M. Wiest, Michael L. Conner, M. Kevin Brown
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Yuan Huang, M. Kevin Brown
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Liang-An Chen, Alan R. Lear, Pin Gao, M. Kevin Brown
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Stephen R. Sardini, Alison L. Lambright, Grace L. Trammel, Humair M. Omer, Peng Liu, M. Kevin Brown
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Organic
Michael L. Conner, Johannes M. Wiest, M. Kevin Brown
Article
Chemistry, Multidisciplinary
Allison M. Bergmann, Stephen R. Sardini, Kevin B. Smith, M. Kevin Brown
ISRAEL JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Erin N. Hancock, Erin L. Kuker, Dean J. Tantillo, M. Kevin Brown
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Review
Biochemistry & Molecular Biology
Erin N. Hancock, Johannes M. Wiest, M. Kevin Brown
NATURAL PRODUCT REPORTS
(2019)
Article
Chemistry, Organic
Yuan Huang, Allison M. Bergmann, M. Kevin Brown
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)