期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 1, 页码 56-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja909874b
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资金
- JSPS KAKENHI [20245022]
- MEXT KAKENHI [21750094, 21200033]
- Global COE Program of MEXT
- Grants-in-Aid for Scientific Research [21200033, 20245022] Funding Source: KAKEN
A highly diastereo- and enantioselective direct Mannich-type reaction of aldimines with 1,3-dicarbonyl compounds using Li(I) BINOLate salts as effective Lewis acid-Bronsted base catalysts has been developed. Li(I) BINOLate salts offered high catalytic activity toward 1,3-dicarbonyl compounds such as diketone, ketoester, ketothioester, ketoamide, and ketolactone. The reactions proceeded at -78 degrees C within 1-2 h in the presence of 1-10 mol % catalyst, which showed a catalytic activity (turnover frequency = 284 h(-1)) quite unlike those of other previous catalysts. Anti products were selectively obtained from acyclic ketoesters without epimerization at an alpha-3 degrees-carbon center, and these are valuable since previous catalysts often gave syn/anti Mixtures or the stereochemistry has not yet been determined.
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