Article
Nanoscience & Nanotechnology
Quyen Van Nguyen, Nhat Pham Van, Huong Le Thi, Giang Le Truong
Summary: We report a quantitative analysis of conductance in tunneling junctions based on r-conjugated oligophenyleneimine (OPI) wires incorporated with thieno[2,3-b]thiophene (TT23) or thieno[3,2-b]thiophene (TT32) units. The results show that the conductance in linear r-conjugated TT32-OPI-n junctions is much greater than in nonlinear r-conjugated TT23-OPI-n junctions, primarily due to an increase in electronic coupling Gamma.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
Tingwei Gao, Chunhui He, Chenguang Liu, Yinqi Fan, Cezhou Zhao, Chun Zhao, Weitao Su, Yannick J. Dappe, Li Yang
Summary: The use of graphene as a new type of electrode at molecular junctions has led to enhanced conductance for longer molecules. Studies involving oligopthiophene based hybrid gold-graphene junctions show similar behavior to alkane-based junctions, as supported by experiments and DFT calculations.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Rajubai D. Bakale, Pramod S. Phatak, Sanket S. Rathod, Prafulla B. Choudhari, Estharla Madhu Rekha, Dharmarajan Sriram, Ravibhushan S. Kulkarni, Kishan P. Haval
Summary: In this study, novel isoniazid-triazole derivatives were synthesized using the click chemistry approach and exhibited potent in vitro antitubercular activity. The compounds showed better antibacterial activity than commonly used drugs and did not display cytotoxicity. In-silico studies further confirmed the interaction between the derivatives and the target enzyme, suggesting their potential as candidates for future tuberculosis treatment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Polymer Science
Xindong Liu, Peng Lei, Xiaoqing Liu, Yifan Li, Yitong Wang, Lei Wang, Qing-Dao Zeng, Yi Liu
Summary: A series of bridged multicyclic conjugated polymers were synthesized by Yamamoto polymerization, and their chemical identities were confirmed by spectroscopy and chromatography. The bridged multicyclic backbone was directly visualized by scanning tunneling microscopy, confirming the topology of the polymers. Like their cyclic monomers, these multicyclic conjugated polymers exhibit intense fluorescence due to aggregation-induced emission, and their fluorescence can be efficiently quenched by picric acid in aqueous media through the static quenching mechanism involving photo-induced electron transfer.
Article
Chemistry, Multidisciplinary
Woojung Lee, Shayan Louie, Austin M. Evans, Nicholas M. Orchanian, Ilana B. Stone, Boyuan Zhang, Yujing Wei, Xavier Roy, Colin Nuckolls, Latha Venkataraman
Summary: This study demonstrates that dynamic molecular structures lead to temperature-dependent conductance in molecular wires. Thermally activated dihedral rotations increase the probability of molecular wires being in a planar conformation, enhancing tunneling probability. Longer molecular wires with more rotational pivot points exhibit larger temperature dependence on conductance.
Article
Materials Science, Biomaterials
Wenjie Han, Miao He, Yunhan Zhang, Junxiang Zhou, Zhigang Li, Xiaoyu Liu, Xiaoyun Sun, Xue Yin, Dongbao Yao, Haojun Liang
Summary: The emergence of synthetic biology enables the construction of cell-assembly biosystems with specific gene expression and function. This study explores the process of cell migration and assembly regulated by cadherins by constructing different cadherin plasmids and introducing them into different cells. The findings have potential applications in the construction of self-assembling synthetic tissues and organoids.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Jesus Valdiviezo, Paulina Rocha, Anastazia Polakovsky, Julio L. Palma
Summary: In the study, the conductance of acene derivatives connected to gold electrodes was calculated using density functional theory (DFT) combined with the nonequilibrium Green's function (NEGF) formalism. It was found that the systems exhibit near length-independent conductance and can show an increase with molecular length, depending on the connection to the electrodes. The analysis attributes this behavior to the decrease of the HOMO-LUMO gap with length, shifting the transmission peaks near the Fermi level.
Article
Biochemistry & Molecular Biology
Mouhi Eddine Hachim, Ali Oubella, Said Byadi, Mourad Fawzi, Yassine Laamari, Lahoucine Bahsis, Aziz Aboulmouhajir, Hamid Morjani, Crtomir Podlipnik, Aziz Auhmani, My Youssef Ait Itto
Summary: In this study, natural (R)-carvone was efficiently used to synthesize several 1,2,3-triazole derivatives with good yields. The cytotoxic activity of the newly synthesized compounds was analyzed, showing medium antitumor activity against selected human cancer cells. Density Functional Theory and molecular docking were employed to determine the electronic properties and stability of the synthesized compounds during inhibition of the anti-apoptotic protein for killing cancer cells, confirming experimental results.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Jan P. Menzel, Benjamin B. Noble, James P. Blinco, Christopher Barner-Kowollik
Summary: Predicting the conversion and selectivity of photochemical reactions presents a unique challenge compared to thermally induced reactivity. The authors introduce a framework for the quantitative prediction of the time-dependent progress of a photoligation reaction and predict LED-light induced conversion through a wavelength-resolved numerical simulation.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Gurjaspreet Singh, Pinky Satija, Fang-Sian Lin, Pawan, Mohit, Sushma, Priyanka, Jashandeep Kaur, Kuo-Chuan Ho
Summary: This article describes the synthesis of cinamaldehyde-based chalcone functionalized organosilatranes and their application in dye-sensitized solar cells. The results demonstrate that the chalcone-based dyes with a siloxyl linker framework exhibit higher energy conversion efficiencies.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biochemical Research Methods
Alexandra Bristiel, Manon Cadinot, Mathieu Pizzonero, Frederic Taran, Dominique Urban, Raphael Guignard, Dominique Guianvarc'h
Summary: The researchers developed a facile method for conjugating relevant probes, ligands, or delivery agents onto oligonucleotides (ONs), which is important for both fundamental studies in chemical biology and improving the pharmacology of ONs in medicinal chemistry. They introduced novel 2'-functionalized nucleoside phosphoramidite monomers that contain bioorthogonal methylcyclopropene or sydnone moieties for the first time to ON solid-phase synthesis, allowing traceless ON postsynthetic modifications with reactive complementary probes through inverse electron-demand Diels-Alder reactions or strain-promoted sydnone-alkyne cycloaddition. These findings expand the bioorthogonal phosphoramidite building blocks and provide a new method for generating labeled ONs.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Aishwaryo Ghosh, Biswajit Pabi, Atindra Nath Pal, Tanusri Saha-Dasgupta
Summary: This study presents a machine learning approach using experimentally measured conductance traces to investigate the formation of atomic chains. By analyzing two data sets, the optimum conditions for forming longer chains are determined, and a deep learning method is used to classify breaking traces and identify features related to long-chain formation. Further insights are gained through ab initio molecular dynamics simulations.
Article
Polymer Science
Yuhan Li, Ziyu Liu, Xiaoran Liu, Feng Gao, Jue Cheng, Junying Zhang
Summary: Polyurethane (PU) is a commonly used polymer material, but its hydrophilic nature poses challenges to its application in flexible electronic displays. In this study, fluorinated chain extenders were introduced into PU to reduce surface energy and improve surface roughness. This resulted in excellent hydrophobicity and oleophobicity, as well as enhanced mechanical properties through physical cross-linking points.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Zongcheng Miao, Yaqin Chu, Lei Wang, Wenqing Zhu, Dong Wang
Summary: This article investigates the synthesis of organic conjugated micro-molecules and the effect of electronic energy level adjustment on their optoelectronic properties. A series of donor-acceptor chromophore substances with high yield, high solubility, and adjustable energy levels are successfully synthesized using a metal-free [2 + 2] click chemistry process. The A-TCNE, A-TCNQ, and A-F4-TCNQ molecules are comprehensively characterized, and their unique nonlinear optical phenomena and powerful intra-molecular charge-transfer interactions provide them with fascinating potential for optoelectronic applications.
Article
Chemistry, Multidisciplinary
Bianca N. Lourenco, Ruben F. Pereira, Cristina C. Barrias, Claudia Fischbach, Carla Oliveira, Pedro L. Granja
Summary: The study suggests CD44v6 as a marker for early detection of gastric cancer and introduces a nanoscale system that selectively targets CD44v6-expressing GC cells. The results confirm the specific targeting ability of the system, highlighting its potential for early diagnosis and therapy of GC.
Article
Chemistry, Multidisciplinary
Fang Fang, Gao Yuting, Luo Liang
Summary: The designed and synthesized mitochondrion-targeting photosensitizer TPC-Py shows efficient production of O-1(2) under white light irradiation and significant cytotoxicity towards cancer cells, making it a promising candidate for imaging-guided clinical PDT for cancer.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2021)
Article
Chemistry, Multidisciplinary
Liyuan Zhao, Sheng Wang, Qigang Hu, Haibo Jia, Yanru Xin, Liang Luo, Fanling Meng
Summary: In this study, a multivalent antibody mimic SPEPS@Au was created by conformational engineering of the complementary-determining regions (CDRs) of antibodies on gold nanoparticles (AuNPs). This mimic effectively inhibits the amyloidogenesis of IAPP, with low toxicity and high binding affinity.
Article
Engineering, Biomedical
Zhenyan He, Yuting Gao, Huimin Zhang, Ying Xue, Fanling Meng, Liang Luo
Summary: A donor-pi-acceptor photosensitizer with near infrared aggregation-induced emission (AIE) is designed and synthesized for imaging-guided two-photon photodynamic therapy (2P-PDT), demonstrating precise cancer treatment through two-photon excitation in the NIR-II window.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Polymer Science
Jinfeng Lin, Mingming Yin, Xiaoming Liu, Fanling Meng, Liang Luo
Summary: This review provides an overview of functional polymer-based nanomaterials for radiosensitization in recent years. Different types of polymer nanomaterials, including polymeric micelles, dendrimers, polymeric nanospheres, nanoscale coordination polymers, polymersomes, and nanogels, are discussed in terms of their action mechanisms, drug loading methods, targeting efficiencies, impact on therapeutic effects, and biocompatibility. Polymeric nano-radiosensitizers have the potential to improve the efficacy of radiotherapy and minimize damage to healthy tissues.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Mengyang Li, Sidan Tian, Fanling Meng, Mingming Yin, Qiang Yue, Shun Wang, Wenting Bu, Liang Luo
Summary: This paper presents a strategy to create continuously multiplexed ultrastrong Raman probes by incorporating C-13 isotopes into the polymer structure, and demonstrates their successful application in information encryption and high-density data storage.
Article
Multidisciplinary Sciences
Mingming Yin, Xiaoming Liu, Ziqiao Lei, Yuting Gao, Jiacheng Liu, Sidan Tian, Zhiwen Liang, Ye Wang, Fanling Meng, Liang Luo
Summary: Poly(diiododiacetylene) (PIDA) is found to be an efficient contrast agent for computed tomography (CT) imaging and can serve as a visual marker for tumor margins. With a high iodine payload and the ability to amplify CT intensity, PIDA shows improved stability and visibility in vivo. It has potential applications in CT-guided preoperative planning, visualization-guided surgery, and imaging-guided radiotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Jiaxin Zhang, Feng Zhou, Zhenyan He, Yufeng Pan, Sen Zhou, Chunjie Yan, Liang Luo, Yuting Gao
Summary: An ultra-efficient photodynamic/chemodynamic theranostics platform was developed by incorporating an aggregation-induced emission (AIE) photosensitizer, TPCI, into iron-bearing montmorillonite (MMT) nanolayers. This platform combines efficient photodynamic therapy (PDT) and continuous chemodynamic therapy (CDT) to effectively eliminate bacteria and promote wound healing with low side effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Yiyi Zhang, Sidan Tian, Liping Huang, Yanan Li, Yuan Lu, Hongyu Li, Guiping Chen, Fanling Meng, Gang L. Liu, Xiangliang Yang, Jiasheng Tu, Chunmeng Sun, Liang Luo
Summary: Researchers have developed a ROS-responsive hydrogel that can protect ICB antibodies and allow for sustained co-delivery of photosensitizers and ICB antibodies. The hydrogel not only inhibits long-term tumor recurrence and metastasis, but also effectively restrains the growth of re-challenged tumors.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Mingming Yin, Junwei Tong, Fanling Meng, Chenchen Liu, Xiaoming Liu, Fang Fang, Zhenyan He, Xiaojuan Qin, Chengbo Liu, Dong Ni, Yuting Gao, Huageng Liang, Xiaoping Zhang, Liang Luo
Summary: This study demonstrates the development of a symbiotic 2D nanohybrid that combines carbon nanomaterials and clay nanomaterials for synergistic cancer therapy and diagnosis. The nanohybrid exhibits high photothermal conversion efficiency and the ability to generate reactive oxygen species, allowing for simultaneous photothermal therapy, chemodynamic therapy, and photoacoustic/magnetic imaging for precision nanomedicine.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Sidan Tian, Yuan Lu, Zhenyan He, Qiang Yue, Zhiyong Zhuang, Yingzhou Wang, Fanling Meng, Liang Luo
Summary: This study reports the development of a poly-ion complex (PIC) that can enhance both fluorescence and reactive oxygen species (ROS) generation in the presence of pathogenic bacteria. The PIC is constructed based on an anionic polydiacetylene and a cationic polymer, which release fluorescence and ROS in the presence of pathogenic bacteria to eliminate them through photodynamic therapy and membrane disruption.
SCIENCE CHINA-CHEMISTRY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Qiang Yue, Liang Luo
Summary: This article presents an integrated strategy for converting polystyrene plastic waste into low-molecular-weight aromatics, addressing both the environmental stress of plastic waste and the high demand of aromatic commodities.
Article
Cell Biology
Xiuxia Wang, Yuanhong Chen, Xiang Yang, Lianghui Cheng, Zhenyan He, Yanru Xin, Shan Huang, Fanling Meng, Peijing Zhang, Liang Luo
Summary: This study discovered a photosensitizer TPCI that can induce ACSL4-independent ferroptosis of cancer cells in photodynamic therapy. TPCI activates ALOX12 to generate lipid reactive oxygen species and trigger cell ferroptosis. Interestingly, confining TPCI exclusively in lysosomes switches the cell death from ferroptosis to apoptosis. The ferroptosis mediated by TPCI-induced ALOX12 activation does not require ACSL4.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Dongya Zhang, Sidan Tian, Yanjie Liu, Meng Zheng, Xiangliang Yang, Yan Zou, Bingyang Shi, Liang Luo
Summary: Effective drug delivery to deep GBM lesions through the blood brain barrier remains challenging. Here, the authors developed a NIR-activatable biomimetic nanogel system that showed high efficacy in orthotopic GBM and GBM stem cells-bearing mouse models.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Liyuan Zhao, Fanling Meng, Yingjie Li, Sujuan Liu, Mengmeng Xu, Fan Chu, Chuanzhou Li, Xiangliang Yang, Liang Luo
Summary: Efficient therapeutic strategies targeting both A beta aggregation and oxidative stress in Alzheimer's disease (AD) have been developed. A multivalent nanobody conjugate with a reactive oxygen species scavenging scaffold was created to mitigate A beta amyloidogenesis, eliminate ROS, and clear A beta plaques simultaneously. This conjugate showed promising results in attenuating AD symptoms and modulating the AD microenvironment through amyloidogenesis inhibition and oxidative stress alleviation.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Mingming Yin, Liyuan Zhao, Sujuan Liu, Sidan Tian, Fanling Meng, Liang Luo
Summary: Based on the study of a series of water-soluble polydiacetylenes, the dependence of polydiacetylene Raman signal on the conjugation length is revealed, which will guide the future design of conjugated polymers for Raman imaging applications.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
