Article
Chemistry, Organic
Baptiste Picard, Takahide Fukuyama, Ilhyong Ryu
Summary: An improved carbonylation method for amide bond formation between aryl iodides and aromatic amines is presented, which does not require a phosphine ligand unlike conventional Pd catalysis. The catalyst system consists of bis(dibenzylideneacetone)palladium (0.5 mol %) and DBU (10 mol %). This method allows the synthesis of various aromatic amides and can be scaled to gram order synthesis under low carbon monoxide pressure.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Peizhuo Lv, Ali Wang, Xin Xie, Yulong Chen, Yuanhong Liu
Summary: An efficient method for the coupling of allyl trifluoroborates with aryl halides has been developed. The method offers high efficiency, mild reaction conditions, wide substrate scope, and functional group compatibility. Mechanistic studies suggest the formation of a pi-allyl nickel(III) intermediate as a key reaction intermediate.
Article
Chemistry, Organic
Lars J. Wesenberg, Alessandra Sivo, Gianvito Vile, Timothy Noel
Summary: In recent years, there has been a trend in the synthetic community to introduce sp(3)-carbon-based fragments in organic compounds through cross-coupling strategies. This study presents a novel nickel-catalyzed electrochemical methodology for reductive cross-electrophile coupling, using inexpensive amine-derived radical precursors and aryl iodides. The use of electrochemistry as a power source reduces waste and avoids chemical reductants, making this approach a more sustainable alternative to traditional cross-coupling methods.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xianqiang Kong, Yiyi Chen, Xiaohui Chen, Zheng-Xuan Lu, Wei Wang, Shao-Fei Ni, Zhong-Yan Cao
Summary: By combining electrocatalysis and nickel catalysis, a unified strategy has been applied to successfully achieve the decarboxylative cross-coupling of four types of alpha-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions. Our strategy provides a practical way for preparing aryl ketones, amides, esters, or aldehydes.
Article
Chemistry, Multidisciplinary
Beatrice Lansbergen, Paola Granatino, Tobias Ritter
Summary: In this study, an undirected para-selective two-step C-H alkylation method for complex arenes useful for late-stage functionalization is presented. By combining site-selective C-H thianthrenation with palladium-catalyzed reductive electrophile cross-coupling, a diverse range of synthetically useful alkylated arenes can be accessed with high selectivity and practicality. The robustness of this transformation is further demonstrated by thianthrenium-based reductive coupling of two complex fragments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Regina M. Oechsner, Ivo H. Lindenmaier, Ivana Fleischer
Summary: We present a nickel catalyzed C-S cross-coupling reaction of aryl and alkenyl triflates with alkyl thiols. By using an air-stable nickel precatalyst, various thioethers could be synthesized under mild reaction conditions within a short reaction time. The reaction demonstrated a broad substrate scope, including pharmaceutically relevant compounds.
Article
Multidisciplinary Sciences
Shi-Chao Ren, Xing Yang, Bivas Mondal, Chengli Mou, Weiyi Tian, Zhichao Jin, Yonggui Robin Chi
Summary: This study reports a decarboxylative radical coupling of carboxylic acids and acyl imidazoles catalyzed by an N-heterocyclic carbene and photocatalyst. The carboxylic acids serve as direct radical precursors, and suitable acyl imidazoles can also be generated in situby a reaction with CDI. The method is extended to three-component coupling by using alkenes as a third coupling partner via a radical relay process. The mild reaction conditions, simplicity, and use of easily available starting materials make this method a powerful strategy for constructing complex ketones and modifying natural products and medicines.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Organic
Ruchi Sharma, M. Ramu Yadav
Summary: Decarboxylative coupling reactions using readily available (hetero)aryl carboxylic acids are an efficient approach for forming new C-C and C-X bonds, with the advantage of eliminating CO2 as a by-product and being more environmentally friendly. This review summarizes recent developments in ipso-decarboxylative C-X bond formations using (hetero)aryl carboxylic acids, and highlights current limitations and future research opportunities in aryl-decarboxylative coupling reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yan Zheng, Bing-Hong Teng, Youcan Zhang, Xiao-Feng Wu
Summary: In this study, a photo-induced metal-free carbonylation reaction of aryl bromides was developed. The reaction showed good reactivity with alcohol and amine nucleophiles, and a variety of useful aryl esters and amides were synthesized at room temperature in moderate to good yields.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Organic
Fusheng Bie, Xuejing Liu, Han Cao, Yijun Shi, Tongliang Zhou, Michal Szostak, Chengwei Liu
Summary: The Pd-catalyzed double-decarbonylative synthesis of aryl thioethers involves an aryl exchange reaction between amides and thioesters, with amides serving as aryl donors and thioesters as sulfide donors. The use of Pd/Xantphos without any additives promotes aryl exchange by C(O)-N/C(O)-S cleavages, allowing for a wide variety of amides and sulfides to be used in the reaction.
Article
Chemistry, Organic
Ke-Jin Jiao, Cong Ma, Dong Liu, Hui Qiu, Bin Cheng, Tian-Sheng Mei
Summary: A highly regioselective Ni-catalyzed electrochemical reductive relay cross-coupling has been developed for the direct acylation of benzylic C(sp(3))-H bonds using alkyl carboxylic acids and alkyl bromides. The method provides an alternative strategy for the synthesis of dialkyl ketones, with good yields and tolerance of various functional groups under mild reaction conditions.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Yi-Bing Yin, Xiao-Shui Peng, Henry N. C. Wong
Summary: A one-pot iron-catalyzed cross-coupling protocol was developed for the synthesis of unsymmetrical biaryls using aryl chlorides, aryl bromides, and magnesium metal. The key step in this reaction is the in situ generation of Grignard reagents.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Organic
Subhajit Bhunia, Subhadip De, Dawei Ma
Summary: BPMO is an appropriate promoter for the Cu-catalyzed N-arylation reaction at room temperature, showing excellent chemoselectivity between aryl iodides and aryl bromides, and good tolerance towards diverse functional groups.
Article
Chemistry, Organic
Boya Feng, Guodong Zhang, Xu Feng, Yu Chen
Summary: A palladium-catalyzed decarbonylative methylation of aryl carboxylic acids using trimethylboroxine as the methylating reagent is described. The Pd(OAc)(2)/XantPhos system is compatible with a wide range of carboxylic acids and derivatives, including aroyl chloride/fluoride. The successful methylation of bioactive molecules and examples of orthogonal cross-couplings demonstrate the practicality of this method.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Mario Franco, Raquel Sainz, Al Mokhtar Lamsabhi, Cristina Diaz, Mariola Tortosa, M. Belen Cid
Summary: This research investigates the application of carbon-based Cu(i) materials in borylation reactions of aliphatic and aromatic halides. The study reveals the previously understudied interactions between graphenic surfaces and Cu(i) salts, highlighting the enhancing effect of graphene on the reactivity of Cu2O metal against halide derivatives. The findings have practical implications for the development of efficient, general, scalable, and sustainable catalytic reactions.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
X. D. Liang, S. Zhang, Z. Y. Wang, C. H. Zhang, D. X. Zhang, C. L. Wu
Summary: A gradient alloy steel prepared by laser melting deposition (LMD) undergoes changes in microstructure, grain refinement, decreased hardness and wear resistance, as well as reduced corrosion resistance after heat treatment.
MATERIALS SCIENCE AND TECHNOLOGY
(2023)
Article
Metallurgy & Metallurgical Engineering
Yu-yan Ren, Sheng-yuan Chen, Tong-yu Liu, Song Zhang, Ying-min Li
Summary: By adding different amounts of Ti into the electromagnetic stirred Al-18wt.%Mg2Si alloy, the effect of Ti on the microstructure and mechanical properties of the alloy was investigated. The results showed that the microstructure was refined after modification with Ti, due to the heterogeneous nucleation of TiAl3 particles on the alpha-Al matrix. Increasing the Ti content and holding time led to the refinement and then coarsening of the primary Mg2Si phase, resulting in an initially increasing and then decreasing trend of the alloy's mechanical properties. The optimal refinement effect of the primary Mg2Si phase and mechanical properties were achieved when 0.5wt.% Ti was added and the holding time was about 20 min.
Article
Physics, Multidisciplinary
Chao Wu, Xiang Gao, Yu-Hao Zhu, Xiao-Ying Han, Bin Duan, Ju Meng, Song-Bin Zhang, Jun Yan, Yong Wu, Jian-Guo Wang
Summary: In this study, the relativistic R-matrix method is used to investigate the electron-impact broadening of spectral lines produced by highly charged Ar XV ions. The results considering resonance structures differ significantly from the distorted wave approach. A new empirical formula with a correction term is proposed to account for the effect of resonances in a relatively wide range of plasma conditions. The fitting parameters for all 47 calculated transitions are provided, with an estimated accuracy within 1%.
Article
Chemistry, Organic
Cong-Cong Feng, Song-Lin Zhang
Summary: A convenient method for preparing aryl formates using difluorocarbene as a CO surrogate is described. This reaction proceeds through sequential O-difluoromethylation of phenol, followed by alpha-C-F bond functionalization of the resulting aryl difluoromethyl ether intermediate by phenol or moisture through fluorosemiacetal or orthoformate intermediates. Late-stage modification of biologically and materially active compounds is demonstrated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Ming-Suo Dai, Zhen-Mei Zheng, Song-Lin Zhang
Summary: Cu(iii)-CF3 compounds are reported as novel coupling reagents for ester synthesis. Carboxylic acids are transformed to trifluoromethyl ester and acyl fluoride activated species that interact with each other. This study demonstrates the broad substrate scope and late-stage application of this method, providing new opportunities for interesting reactions without transferring a CF3 group to the products.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yi-Hong Liao, Song Zhang
Summary: This paper presents an absolute phase unwrapping method for high-speed three-dimensional shape measurement on a single-camera, single-projector structured light system. The method utilizes speckle-embedded three-step phase-shifted patterns to obtain the wrapped phase of the object and employs the Semi-Global Matching (SGM) algorithm to establish the coarse correspondence between images. A computational framework is then used to determine the fringe order pixel by pixel. The experimental results demonstrate the high-speed and high-quality 3D measurements achieved by the proposed method for complex scenes.
Review
Endocrinology & Metabolism
Hanjing Zhou, Chenqiong Zhao, Peixin Wang, Weijie Yang, Haiyan Zhu, Songying Zhang
Summary: Placental dysfunction refers to impaired placental function and inadequate supply of oxygen and nutrients to the fetus, resulting in fetal growth restriction. Deficient trophoblast syncytialization, inadequate trophoblast invasion, and impaired vascular remodeling contribute to placental dysfunction. Abnormal expression of proteins and signaling pathways involved in trophoblast syncytialization has been found in the placentas of pregnancies complicated by intrauterine growth restriction (IUGR).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Cuicui Li, Yilun Cai, Jinrong Hu, Jiawei Liu, Honglian Dai, Qingfang Xu, Chitengfei Zhang, Xian Zhang, Kai Liu, Marina L. Kosinova, Takashi Goto, Rong Tu, Song Zhang
Summary: This study fabricated a SiC/graphene composite film via laser chemical vapor deposition (LCVD) as a dopamine (DA) sensor. The film exhibited excellent electrocatalytic activity, low detection limit, and high sensitivity. Its three-dimensional porous network structure enhanced electron transfer rate and catalytic active site exposure, while reducing interfacial resistance. Moreover, the film showed good biocompatibility for biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Song Zhang, Chongjie Wang, Tenghua Gao, Jinrong Hu, Pengjian Lu, Bingjian Guo, Qingfang Xu, Kai Liu, Baowen Li, Rong Tu, Meijun Yang, Kazuya Ando
Summary: Interfacial engineering can be used to obtain EMI shielding composites with thin thickness. In this study, a Ni nanoparticle/SiC nanowhisker/carbon cloth nanoheterostructure was fabricated, and the formation of a Ni/SiC interface was found to enhance dielectric loss and suppress reflection, resulting in excellent EMI shielding effectiveness. The material also exhibits high flexibility and long-term stability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Zhen-Mei Zheng, Ning Chen, Ming-Suo Dai, Song-Lin Zhang
Summary: This study reports the reactivity properties of Cu(III)-CF3 compounds with anilines, showing distinct reactivities based on their basicity, resulting in the formation of formamides or hydrazines. This is achieved through the competing generation of difluorocarbene and N-centered radicals, controlled by the basicity of the reaction solution. The study demonstrates the unusual use of high-valent Cu(III) trifluoromethyl compounds as hydrogen-abstracting reagents for dehydrogenative reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Dou-Dou Chen, Song-Lin Zhang
Summary: This study reports the geminal amino- and oxy-trifluoromethylation of ortho-ethynyl anilines/ phenols using phenCu(III)(CF3)(3), which provides a concise and controllable synthesis of valuable trifluoromethylated N and O-heterocyclic compounds. The method circumvents the regioselectivity issue often encountered in C H trifluoromethylation of arenes/heteroarenes and suppresses the competing vicinal fluoro-trifluoromethylation of terminal alkynes. The synthetic value of Cu(III) CF3 compounds in medicinal chemistry is highlighted.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Materials Science, Multidisciplinary
H. F. Zhang, S. Zhang, C. L. Wu, C. H. Zhang, X. L. Bai, X. Y. Sun, J. Chen
Summary: The WC-Co composite coating was successfully prepared on SS 316L using plasma arc welding technology. The composition, microstructure, and microhardness of the coating were analyzed. Corrosion behavior, including electrochemical corrosion, cavitation erosion, and erosion corrosion, was tested. The results showed that the WC-Co coating had excellent metallurgical bonding with the substrate, significantly increased microhardness, and improved corrosion resistance compared to SS 316L.
MATERIALS SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jue Zhou, Zhou Jiang, Leyi Fu, Fan Qu, Minchen Dai, Ningning Xie, Songying Zhang, Fangfang Wang
Summary: The study aimed to identify molecular subtypes and related genes associated with preterm labor risk in women with polycystic ovary syndrome (PCOS). Through analysis of multiple gene expression datasets, two molecular subtypes were identified in PCOS patients, and key genes related to preterm labor were determined. These findings help uncover the heterogeneity of clinical pregnancy complications in women with PCOS.
Review
Cardiac & Cardiovascular Systems
Song Zhang, Panpan Hao, Jiaxin Li, Qi Zhang, Xiaoying Yin, Jiali Wang, Yuguo Chen
Summary: The study aims to investigate the effects of growth differentiation factor-15 (GDF-15) on all-cause death, cardiovascular death, MI, and stroke in patients with coronary artery disease (CAD). The results showed that patients with elevated GDF-15 levels had significantly increased risks of all-cause death, cardiovascular death, and MI, but a lower predictive effect on stroke. Further studies are needed to explore the association between GDF-15 and stroke outcome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
