期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 41, 页码 14638-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9066354
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资金
- National Science Foundation [CHE0809659, CHE-06-19638]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0809659] Funding Source: National Science Foundation
The addition of a stabilized sulfur ylide (generated by the rhodium-catalyzed reaction of Ph2S with ethyl diazoacetate) to N-acylhydrazones promoted by a chiral silane Lewis acid leads to the highly diastereo- and enantioselective synthesis of B-chloro-alpha-hydrazido esters. The addition of electron-rich arenes and ZnCl2 to the reaction mixture Leads to the highly diastereo- and enantioselective one-pot synthesis of diarylalanine derivatives. In both cases, the silane Lewis acid responsible for the first reaction performs the second function of activating the aziridine intermediate toward nucleophilic attack.
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