Article
Chemistry, Multidisciplinary
Tianqi Liu, Ge Li, Nannan Shen, Linqin Wang, Brian J. J. Timmer, Alexander Kravchenko, Shengyang Zhou, Ying Gao, Yi Yang, Hao Yang, Bo Xu, Biaobiao Zhang, Marten S. G. Ahlquist, Licheng Sun
Summary: The outer coordination sphere of metalloenzyme influences its catalytic activity. By designing and synthesizing molecular catalysts with well-defined outer spheres, a significant increase in the rate of catalytic water oxidation has been achieved.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Mechanics
Jeong Hyun Kim, Young Mo Lee, Jae Hwa Lee, Jooha Kim
Summary: The study reveals that surface roughness in Couette-Poiseuille flow can suppress the collective motion of negative streamwise velocity fluctuating structures near the surface, leading to a weakened large-scale ejection and reduced strength of VLSM.
Article
Chemistry, Physical
Zhiqiang Wei, Chang Liu, Yuzhao Zhang, Huilin Fan, Runguo Zheng, Zhiyuan Wang, Yuan Wang, Hamidreza Arandiyan, Zongping Shao, Hongyu Sun, Yanguo Liu
Summary: In this study, we developed a novel N-doped mesoporous hollow carbon sphere with a smooth exterior and a wrinkled interior structure. The obtained carbon sphere exhibits superior rate performance and sufficient capacity for high-energy storage, providing a new insight into the structural design and morphological control of carbon-based materials.
Article
Chemistry, Multidisciplinary
Nishanth D. Tirukoti, Liat Avram, Reut Mashiach, Hyla Allouche-Arnon, Amnon Bar-Shir
Summary: An MRI-responsive agent that self-assembles into a large supramolecular structure under physiological conditions has been designed. The obtained assembly allows for an extended time window for in vivo studies, as demonstrated by a fluorine-19 probe designed to detect Zn2+ using F-19-iCEST MRI.
CHEMICAL COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fei Han, Xin Jin, Xiaojun Yuan, Zehua Bai, Qi Wang, Haifeng Xie
Summary: This study evaluated the interactions of two phosphate ester monomers with hydroxyapatite and collagen, and analyzed their impact on dentine bonding. Results showed that PENTA had weaker interactions with dentine compared to 10-MDP, but provided better dentine tubule sealing and hydrophilicity. While both monomers initially increased μTBS, the decrease during aging was more significant in the PENTA group.
JOURNAL OF DENTISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sara Chirayil, Veronica Clavijo Jordan, Andre F. Martins, Namini Paranawithana, S. James Ratnakar, A. Dean Sherry
Summary: The Mn(II)-based zinc-sensitive MRI contrast agent MnPyC3A-BPEN has shown superior kinetic inertness and stability compared to GdDTPA, making it a reliable alternative for detecting glucose-stimulated zinc secretion in the pancreas and prostate.
INORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Natalia Ziolkowska, Martin Vit, Richard Laga, Daniel Jirak
Summary: This study presents a novel bio-responsive phosphorus probe doped with iron for dual proton and phosphorus magnetic resonance imaging. The probe consists of non-toxic biodegradable calcium phytate nanoparticles doped with cleavable paramagnetic Fe3+ ions. Iron release from the probe influences the MR signals of protons and phosphorus, potentially due to biochemical changes in the environment with strong iron chelators.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Eva Boszormenyi, Orsolya Domotor, Bence Kutus, Gabor Varga, Gabor Peintler, Pal Sipos
Summary: The complexation of Nd(III) with D-gluconate, D-galactonate, and L-gulonate in aqueous solutions was studied in the neutral to hyperalkaline pH range. The study focused on the structural aspects of the complexes using spectroscopic techniques such as NMR, CD, and Raman spectroscopies. It was found that the carboxylate group of each ligand played an essential role in the coordination to Nd(III), and other hydroxyl or alkoxide groups were also coordinated in solutions with pH > 5. The most appropriate model for describing the systems at pH > 12 was proposed based on the experimental observations.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Materials Science, Biomaterials
Minmin Liang, Weixiu Zhou, Haifeng Zhang, Jutian Zheng, Jiaomin Lin, Lu An, Shiping Yang
Summary: In this study, a pH- and glutathione (GSH)-responsive T-1-T-2 dual-mode contrast agent, Fe3O4@ZIF-8-Zn-Mn nanoparticles (NPs), was constructed to improve the sensitivity and accuracy of magnetic resonance imaging (MRI). The NPs showed good stability and weak T-1-T-2 dual-mode MRI contrast effect under neutral conditions, but could be disassembled and release Fe3O4 NPs and paramagnetic Mn2+ ions under acidic environment (pH = 6.5-5.5) and in the presence of GSH (0-4 mM), resulting in enhanced T-1 and T-2 imaging performances. In vivo MRI experiments demonstrated the potential of Fe3O4@ZIF-8-Zn-Mn NPs as a tumor microenvironment-responsive T-1-T-2 dual-mode contrast agent for sensitive tumor imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Pradyumn Sharma, Rakesh Vaiwala, Srividhya Parthasarathi, Nivedita Patil, Anant Verma, Morris Waskar, Janhavi S. Raut, Jaydeep Kumar Basu, K. Ganapathy Ayappa
Summary: This study investigates the superior antimicrobial activity of shorter-chain fatty acid surfactant, laurate, compared to longer-chain surfactants in contact with Escherichia coli. Molecular dynamics simulations reveal that laurate has the highest translocation events across peptidoglycan, indicating its ability to disrupt the bacterial cell wall. The study also demonstrates that laurate induces greater structural disruption of the inner membrane compared to other surfactants. These findings provide molecular insights into surfactant translocation and membrane disruption, aiding in the development of antimicrobial formulations and therapeutics.
Article
Chemistry, Physical
Meng -Zhu Qin, Yanyan Bian, Huai -Yuan Niu, Wen-Xin Fu, Xue-Gang Zhang, Qi-Yao Hu, Duan Guo, Cheng-Gang Niu, Lei Zhang
Summary: This study selected sodium citrate as the carbon source and self-template for synthesizing B-doped carbonaceous materials to activate peroxydisulfate (PDS). Multiple characterizations and experiments confirmed that the electron transfer regime was responsible for PDS activation. The adsorption of PDS onto the catalyst surface through inner-sphere interaction generated metastable surface complexes, while the interaction between BPA and the catalyst was verified as charge-assisted hydrogen bonding. BC3 was identified as the main active site. This work further elucidated interactions and the vital role of BC3 in PDS activation.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Chemistry, Medicinal
Giuseppe Gambino, Tanja Gambino, Liam Connah, Francesca La Cava, Henry Evrard, Goran Angelovski
Summary: The relevance of MRI as a diagnostic tool has greatly expanded with the development of molecular imaging, which is partly attributed to the advancement of targeted MRI contrast agents. By combining bioresponsive contrast agents with targeting vectors, novel and efficient molecular imaging methods can be developed.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Andrew M. M. Hogan, A. S. M. Zisanur Rahman, Anna Motnenko, Aakash Natarajan, Dustin T. T. Maydaniuk, Beltina Leon, Zayra Batun, Armando Palacios, Alejandra Bosch, Silvia T. T. Cardona
Summary: This study systematically investigated the effects of antibiotics on the cell envelope of Burkholderia cepacia complex, and identified resistance and susceptibility determinants associated with the cell envelope. The findings provide insights into new drug targets and potential antibiotic combination strategies, which can contribute to improving antibacterial therapies.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Maheshwaran Duraiyarasu, S. Senthil Kumaran, Ramasamy Mayilmurugan
Summary: A dual-modal T1-MRI and optical imaging probe, Fe(C12CAT)3, was synthesized and characterized. The probe exhibited enhanced r1-relaxivity upon interaction with human serum albumin, allowing visualization of the acidic pH environment of cells.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)