Article
Chemistry, Multidisciplinary
Ren-Xiao Liang, Jian-Fei Chen, Ying-Ying Huang, Ya-Ping Yu, Han-Yue Zhang, Yu-Feng Song, Gavin Chit Tsui, Yi-Xia Jia
Summary: Highly enantioselective palladium-catalyzed dearomative reductive Heck reaction and domino Heck-Suzuki reaction of 2-CF3-indoles have been developed. A variety of indolines bearing different stereocenters can be obtained using different reaction systems.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Zhaohui Zong, Zhaozhen Cao, Aiyou Hao, Pengyao Xing
Summary: This study reveals the crucial role of water in the functional properties of chiral molecular systems, proposing a hydration-driven chiral molecular rotor system. The impact of water on the chiral molecular movement behavior is discussed, highlighting the potential for fabricating external field-responsive chiral materials.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Organic
Shivani Gayyur, Shivani Choudhary, Ruchir Kant, Nayan Ghosh
Summary: A straightforward and atom-economical one-pot protocol catalyzed by gold(I) and zinc(II) has been demonstrated for the synthesis of amine-substituted diaryl[c,h][1,6]naphthyridines from two different aromatic nitriles. This dual-catalytic strategy is highly efficient and yields a variety of tetracyclic heteroaromatic products in good to excellent yields. Furthermore, the base can efficiently catalyze the second annulation step, resulting in structurally unique thiophene-fused [1,6]naphthyridines with good yields.
Review
Chemistry, Multidisciplinary
Diptiprava Sahoo, Renitta Benny, Nithish Kumar KS, Soumen De
Summary: Chirality plays a crucial role in chemistry and biochemistry, with a growing interest in dynamic chirality. Research in this area is essential for controlling the directionality in molecular motors and has important implications in other fields as well.
Article
Chemistry, Multidisciplinary
Di Zhang, Youyuan Xiong, Yingjie Guo, Lei Zhang, Zheng Wang, Kuiling Ding
Summary: In this study, a Pd-catalyzed enantioselective domino Heck carbonylation reaction was developed using o-iodoacrylanilides, terminal alkynes, and water as nucleophiles. The reaction afforded a diverse range of beta-carbonylated 2-oxindole derivatives with a 3,3-disubstituted all-carbon quaternary stereocenter in high yields and good to excellent enantioselectivities. The synthetic utility of the methodology was demonstrated through gram-scale synthesis of various compounds, showcasing its potential for efficient chiral 2-oxindole synthesis.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Shaomin Chen, Rongxian Bai, Minghao Li, Ping Liu, Yanlong Gu
Summary: Adding an additive-like component to induce acid-acid-catalyzed tandem reactions can enrich method diversity, simplify operation, and enhance synthetic efficiency.
Article
Chemistry, Organic
Jiang Wang, Pinzhuo Ren, Gongping Gu, Zongyou Jiang, Bolin Xiang, Shi Tang, Ai-Qun Jia
Summary: An efficient and convenient method for the construction of diverse free (N-H)-benzazepinoindoles using Pd-catalyzed C(sp(2))-H imidoylative cyclization of 3-(2-isocyanobenzyl)-1H-indoles was developed. The reaction displays a broad substrate scope and can be scaled up, providing a practical route to valuable bioactive azepinoindoles.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Andrew Whyte, Jonathan Bajohr, Ramon Arora, Alexa Torelli, Mark Lautens
Summary: An enantioselective consecutive cyclization/coupling process catalyzed by palladium was reported in this study. The stereoinduction was achieved through an enantioselective carbopalladation, leading to the generation of an intermediate that promotes a nucleopalladation step. This dual cyclization sequence was compatible with various nucleophiles and aryl iodides, producing numerous bisheterocycles in good yields and high regio- and enantioselectivities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Robin Schulte, Heiko Ihmels
Summary: The photochromic norbornadiene/quadricyclane system is a promising candidate for molecular solar thermal (MOST) energy storage. Borylated norbornadienes were synthesized as versatile building blocks using Pd-catalyzed Suzuki-Miyaura coupling reactions with haloarenes, showing potential for the development of new derivatives.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Meruyert Binayeva, Xinghua Ma, Pejman Ghaemimohammadi, Mark R. Biscoe
Summary: We have developed a general process for the formation of enantioenriched benzylic stereocenters via stereospecific Pd-catalyzed cross-coupling reactions. This process demonstrates excellent stereospecificity and can be applied to a wide range of electrophilic coupling partners. Additionally, we have successfully demonstrated the first Sn-selective cross-coupling reaction using a vicinal alkylborylstannane nucleophile, highlighting the importance of cyclohexyl spectator ligands in achieving selective transfer of the benzylic unit.
Review
Chemistry, Multidisciplinary
Bing Xu, Quanpu Wang, Chao Fang, Zhan-Ming Zhang, Junliang Zhang
Summary: This review summarizes the latest advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years. The review is organized into thirteen sections based on the different types of transformations involved. Chiral palladium catalysts have shown outstanding features in promoting a plethora of enantioselective cyclization reactions, providing convenient access to structurally diverse chiral carbo- and hetero-cycles.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Liangxin Fan, Xinxin Zhu, Xingyuan Liu, Fangyu He, Guoyu Yang, Cuilian Xu, Xifa Yang
Summary: This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.
Article
Chemistry, Organic
Maddali L. N. Rao, Sachchida Nand, Venneti N. Murty
Summary: A Pd-catalyzed domino cross-coupling methodology was utilized to synthesize various 4-(arylethynyl)coumarin derivatives with good to high product yields. The reactions involved 4-(gem-dibromovinyl)coumarins and sub-stoichiometric amounts of triarylbismuth reagents, demonstrating versatile reactivity and successful mono-, chemoselective, and bis-coupling reactions.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Zhiyang Zhang, Janina Kneipp
Summary: SAMs on plasmonic substrates are essential for SERS applications, while LSPRs can support a variety of chemical modifications. Micropatterning using SAMs on gold nano-substrates enables rewritable SERS security labels and functionalized sensing arrays, showcasing different plasmon-catalyzed reactions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Organic
Alma R. Perez, Evan C. Bornowski, Lei Chen, John P. Wolfe
Summary: The synthesis of indanes containing substituted cyanomethyl groups at C2 has been achieved through Pd-catalyzed coupling reactions. Alkenyl triflates were used to generate partially saturated analogues via similar transformations. The use of a preformed BrettPhosPd(allyl)(Cl) complex as a precatalyst was crucial for the success of these reactions.
Review
Chemistry, Inorganic & Nuclear
Matthias Kuenzle, Marcel Lach, Tobias Beck
DALTON TRANSACTIONS
(2018)
Editorial Material
Biochemistry & Molecular Biology
Marcel Lach, Matthias Kuenzle, Tobias Beck
Article
Chemistry, Inorganic & Nuclear
Matthias Kuenzle, Thomas Eckert, Tobias Beck
INORGANIC CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Matthias Kuenzle, Marcel Lach, Made Budiarta, Tobias Beck
Review
Chemistry, Multidisciplinary
Matthias Kuenzle, Marcel Lach, Tobias Beck
ISRAEL JOURNAL OF CHEMISTRY
(2019)
Article
Food Science & Technology
Marieke Sternkopf, Sven Thoroee-Boveleth, Tobias Beck, Kirsten Oleschko, Ansgar Erlenkoetter, Ulrich Tschulena, Sonja Steppan, Thimoteus Speer, Claudia Goettsch, Vera Jankowski, Joachim Jankowski, Heidi Noels
Review
Chemistry, Organic
Brandon Charles Seychell, Tobias Beck
Summary: This minireview provides an overview of protein-protein interactions, common characterisation methods, and their role in protein complex formation, emphasizing the importance of understanding these interactions for various applications, including drug design. The exploration of protein-protein interactions and their discovery offers insights into the functioning of protein complexes, which constitute the majority of proteins.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Carlos Sanchez-Cano, Ramon A. Alvarez-Puebla, John M. Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N. Chapman, Chunying Chen, Bruce E. Cohen, Andre L. C. Conceicao, David P. Cormode, Daxiang Cui, Kenneth A. Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni, Claus-C Glueer, Florian Gruener, Moustapha Hassan, Yong Hu, Yalan Huang, Samuel Huber, Nils Huse, Yanan Kang, Ali Khademhosseini, Thomas F. Keller, Christian Koernig, Nicholas A. Kotov, Dorota Koziej, Xing-Jie Liang, Beibei Liu, Sijin Liu, Yang Liu, Ziyao Liu, Luis M. Liz-Marzan, Xiaowei Ma, Andres Machicote, Wolfgang Maison, Adrian P. Mancuso, Saad Megahed, Bert Nickel, Ferdinand Otto, Cristina Palencia, Sakura Pascarelli, Arwen Pearson, Oula Penate-Medina, Bing Qi, Joachim Raedler, Joseph J. Richardson, Axel Rosenhahn, Kai Rothkamm, Michael Rubhausen, Milan K. Sanyal, Raymond E. Schaak, Heinz-Peter Schlemmer, Marius Schmidt, Oliver Schmutzler, Theo Schotten, Florian Schulz, A. K. Sood, Kathryn M. Spiers, Theresa Staufer, Dominik M. Stemer, Andreas Stierle, Xing Sun, Gohar Tsakanova, Paul S. Weiss, Horst Weller, Fabian Westermeier, Ming Xu, Huijie Yan, Yuan Zeng, Ying Zhao, Yuliang Zhao, Dingcheng Zhu, Ying Zhu, Wolfgang J. Parak
Summary: X-ray-based analytics are widely used in physics, chemistry, materials science, and engineering, but their full potential in life sciences and medicine has not been fully utilized. Current and upcoming advances in applying these techniques to investigate the nano-bio interface are discussed, along with addressing current limitations and potential strategies for future in vivo use.
Article
Multidisciplinary Sciences
Sebastian Guenther, Patrick Y. A. Reinke, Yaiza Fernandez-Garcia, Julia Lieske, Thomas J. Lane, Helen M. Ginn, Faisal H. M. Koua, Christiane Ehrt, Wiebke Ewert, Dominik Oberthuer, Oleksandr Yefanov, Susanne Meier, Kristina Lorenzen, Boris Krichel, Janine-Denise Kopicki, Luca Gelisio, Wolfgang Brehm, Ilona Dunkel, Brandon Seychell, Henry Gieseler, Brenna Norton-Baker, Beatriz Escudero-Perez, Martin Domaracky, Sofiane Saouane, Alexandra Tolstikova, Thomas A. White, Anna Haenle, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, Miriam Barthelmess, Frank Schluenzen, P. Lourdu Xavier, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Vasundara Srinivasan, Bruno Alves Franca, Martin Schwinzer, Hevila Brognaro, Cromarte Rogers, Diogo Melo, Joanna J. Zaitseva-Doyle, Juraj Knoska, Gisel E. Pena-Murillo, Aida Rahmani Mashhour, Vincent Hennicke, Pontus Fischer, Johanna Hakanpaa, Jan Meyer, Philip Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Andrea R. Beccari, Gleb Bourenkov, David von Stetten, Guillaume Pompidor, Isabel Bento, Saravanan Panneerselvam, Ivars Karpics, Thomas R. Schneider, Maria Marta Garcia-Alai, Stephan Niebling, Christian Guenther, Christina Schmidt, Robin Schubert, Huijong Han, Juliane Boger, Diana C. F. Monteiro, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian G. Feiler, Manfred S. Weiss, Eike-Christian Schulz, Pedram Mehrabi, Katarina Karnicar, Aleksandra Usenik, Jure Loboda, Henning Tidow, Ashwin Chari, Rolf Hilgenfeld, Charlotte Uetrecht, Russell Cox, Andrea Zaliani, Tobias Beck, Matthias Rarey, Stephan Guenther, Dusan Turk, Winfried Hinrichs, Henry N. Chapman, Arwen R. Pearson, Christian Betzel, Alke Meents
Summary: The study identified 37 compounds that bind to the SARS-CoV-2 main protease through a high-throughput x-ray crystallographic screen of two repurposing drug libraries. Among these compounds, one peptidomimetic and six nonpeptidic compounds showed antiviral activity in cell-based viral reduction assays at nontoxic concentrations. The identification of two allosteric binding sites presents potential targets for drug development against SARS-CoV-2.
Article
Chemistry, Physical
Made Budiarta, Wenjing Xu, Lukas Schubert, Maria Meledina, Alexander Meledin, Dominik Woell, Andrij Pich, Tobias Beck
Summary: The integration of ferritin containers into microgels can protect ferritin against degradation by protease and a stimuli-responsive microgel system can be designed by employing an acid-degradable crosslinker. Experimental results showed that around 80% of the ferritin containers were integrated into microgels with approximately 85% and 50% released in buffer pH 2.5 and 4.0, respectively.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Marcel Lach, Christian Strelow, Andreas Meyer, Alf Mews, Tobias Beck
Summary: In this study, protein nanocages were used as nanoscale building blocks for the assembly of gold nanoparticles and fluorescent molecules, resulting in the synthesis of binary nanomaterials with highly ordered structures. The cargo was encapsulated into the protein nanocages using a dis- and reassembly approach. The strong exciton-plasmon coupling between the encapsulated fluorophores and gold nanoparticles was observed in the binary crystals.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Hendrik Boehler, Setareh Orth-Alampour, Constance Baaten, Maria Riedner, Joachim Jankowski, Tobias Beck
Summary: This study demonstrates the potential of protein-based adsorbents for clearing uremic toxins, with enhanced adsorption capacity and maintained biocompatibility through functionalization.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Made Budiarta, Sathi Roy, Tobias Katenkamp, Neus Feliu, Tobias Beck
Summary: Due to its pharmacological properties, ferritin (Ftn) is used as a drug delivery vehicle to reduce the cardiotoxicity of doxorubicin (DOX) in chemotherapy. However, DOX encapsulation in Ftn faces challenges such as precipitation and low protein recovery yield. A new strategy using cysteine-maleimide conjugation for DOX encapsulation in Ftn is proposed and shown to be more efficient. The surface charges of Ftn variants affect the cytotoxicity, DOX loading, and cellular uptake mechanism.
Article
Chemistry, Multidisciplinary
Niklas O. Junker, Anja Lindenau, Michael Ruetten, Marcel Lach, Alexander Nedilko, Dmitry N. Chigrin, Gero von Plessen, Tobias Beck
Summary: The optical properties of 3D metacrystals made of gold nanoparticles in protein nanocages are investigated. These metacrystals have good structural and optical quality with sizes in the tens of micrometers range. Through microspectroscopy measurements and model calculations, it is shown that the metacrystals exhibit plasmonic absorption in the green wavelength range and are mostly transparent in the red and infrared ranges. By using empty nanocages as placeholders in the metacrystal lattice, the absorption strength of the metamaterial can be controlled. Measurements on a pyramidal metacrystal demonstrate deflection of visible light, indicating anomalous refraction at short wavelengths and normal refraction at long wavelengths. The refractive dispersion is attributed to the optical dispersion relation of the plasmonic metamaterial.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Matthias Kuenzle, Johanna Mangler, Marcel Lach, Tobias Beck
