期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 17, 页码 6076-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja901212h
关键词
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资金
- National Institutes of Health [NIGMS RO1 GM63540]
- Dreyfus Foundation
- Pfizer
- NSF-REU program [CHE-0649039]
Utilizing the rapidly synthesized Quinox ligand and commercially available aqueous TBHP, a Wacker-type oxidation has been developed, which efficiently converts the traditionally challenging substrate class of protected allylic alcohols to the corresponding acyloin products. Additionally, the catalytic system is general for several other substrate classes, converting terminal olefins to methyl ketones, with short reaction times. The system is scalable (20 mmol) and can be performed with a reduced catalyst loading of 1 mol%. Enantioenriched substrates undergo oxidation with complete retention of enantiomeric excess.
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